Motif ID: Nr6a1

Z-value: 0.544


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_389264540.241.6e-01Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_42245907 2.827 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr14_+_12189943 2.816 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr17_+_72918298 2.697 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr4_-_45530330 2.662 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr1_-_79858627 2.143 ENSMUST00000027467.4
 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr19_+_46707443 2.086 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr9_-_96437434 1.960 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr13_-_24761440 1.934 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr2_+_172472512 1.589 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr17_-_46645128 1.464 ENSMUST00000003642.6
 Klc4
kinesin light chain 4
chr7_-_145283915 1.453 ENSMUST00000058022.4
 Tpcn2
two pore segment channel 2
chr5_-_5694024 1.249 ENSMUST00000115425.2
ENSMUST00000115427.1
ENSMUST00000115424.2
ENSMUST00000015797.4
 Steap2



six transmembrane epithelial antigen of prostate 2



chr1_-_151428440 1.219 ENSMUST00000064771.5
 Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr7_+_30314810 1.199 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr6_+_83349446 1.112 ENSMUST00000136501.1
 Bola3
bolA-like 3 (E. coli)
chr15_-_98165613 0.990 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr5_-_30073554 0.966 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chr5_-_137610626 0.787 ENSMUST00000142675.1
 Pcolce
procollagen C-endopeptidase enhancer protein
chr12_+_3807017 0.770 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr5_-_5694559 0.748 ENSMUST00000115426.2
 Steap2
six transmembrane epithelial antigen of prostate 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 2.8 GO:1901998 toxin transport(GO:1901998)
0.0 2.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.5 2.7 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.5 2.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.2 2.1 GO:0009404 toxin metabolic process(GO:0009404)
0.4 2.0 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 1.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.5 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 1.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 1.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 1.0 GO:0046078 dUMP metabolic process(GO:0046078)
0.2 0.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.7 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.7 GO:0003341 cilium movement(GO:0003341)
0.2 0.6 GO:0009838 abscission(GO:0009838)
0.1 0.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.4 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 2.0 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.1 1.4 GO:0001741 XY body(GO:0001741)
0.1 1.2 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.7 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.7 GO:0030286 dynein complex(GO:0030286)
0.1 0.6 GO:0070652 HAUS complex(GO:0070652)
0.1 0.6 GO:0090543 Flemming body(GO:0090543)
0.0 0.6 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0045179 apical cortex(GO:0045179)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 2.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.7 2.0 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 1.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.4 1.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 1.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.7 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.7 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.0 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.4 GO:0003951 NAD+ kinase activity(GO:0003951)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.3 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling