Motif ID: Nr6a1

Z-value: 0.544


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_389264540.241.6e-01Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_42245907 2.827 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr14_+_12189943 2.816 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr17_+_72918298 2.697 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr4_-_45530330 2.662 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr1_-_79858627 2.143 ENSMUST00000027467.4
 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr19_+_46707443 2.086 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr9_-_96437434 1.960 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr13_-_24761440 1.934 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr2_+_172472512 1.589 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr17_-_46645128 1.464 ENSMUST00000003642.6
 Klc4
kinesin light chain 4
chr7_-_145283915 1.453 ENSMUST00000058022.4
 Tpcn2
two pore segment channel 2
chr5_-_5694024 1.249 ENSMUST00000115425.2
ENSMUST00000115427.1
ENSMUST00000115424.2
ENSMUST00000015797.4
 Steap2



six transmembrane epithelial antigen of prostate 2



chr1_-_151428440 1.219 ENSMUST00000064771.5
 Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr7_+_30314810 1.199 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr6_+_83349446 1.112 ENSMUST00000136501.1
 Bola3
bolA-like 3 (E. coli)
chr15_-_98165613 0.990 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr5_-_30073554 0.966 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chr5_-_137610626 0.787 ENSMUST00000142675.1
 Pcolce
procollagen C-endopeptidase enhancer protein
chr12_+_3807017 0.770 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr5_-_5694559 0.748 ENSMUST00000115426.2
 Steap2
six transmembrane epithelial antigen of prostate 2
chr4_-_82505274 0.683 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr1_+_151428612 0.663 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr4_-_125065603 0.660 ENSMUST00000036383.3
 Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr11_+_6560183 0.660 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr12_+_3807076 0.656 ENSMUST00000174817.1
 Dnmt3a
DNA methyltransferase 3A
chr10_+_128083273 0.655 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr4_+_43632185 0.622 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr8_-_109693235 0.612 ENSMUST00000034164.4
 Ist1
increased sodium tolerance 1 homolog (yeast)
chr6_-_57535422 0.564 ENSMUST00000042766.3
 Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr18_-_77767752 0.554 ENSMUST00000048192.7
 Haus1
HAUS augmin-like complex, subunit 1
chr2_+_157424255 0.522 ENSMUST00000029175.7
ENSMUST00000092576.4
 Src

Rous sarcoma oncogene

chr11_-_100770926 0.434 ENSMUST00000139341.1
ENSMUST00000017891.7
 Ghdc

GH3 domain containing

chr9_+_73102398 0.414 ENSMUST00000174203.2
ENSMUST00000034737.6
ENSMUST00000173734.2
ENSMUST00000167514.1
 Gm20509
Khdc3


predicted gene 20509
KH domain containing 3, subcortical maternal complex member


chr6_+_48593927 0.395 ENSMUST00000135151.1
 Repin1
replication initiator 1
chr4_+_155562348 0.382 ENSMUST00000030939.7
 Nadk
NAD kinase
chr15_+_100038635 0.368 ENSMUST00000100203.3
 Dip2b
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr9_+_50603892 0.361 ENSMUST00000044051.4
 Timm8b
translocase of inner mitochondrial membrane 8B
chr9_-_121839460 0.361 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr5_-_136986829 0.358 ENSMUST00000034953.7
ENSMUST00000085941.5
 Znhit1

zinc finger, HIT domain containing 1

chr15_-_73184840 0.356 ENSMUST00000044113.10
 Ago2
argonaute RISC catalytic subunit 2
chr11_-_69822144 0.343 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr15_-_98165560 0.332 ENSMUST00000123922.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr11_+_120677226 0.326 ENSMUST00000129644.2
ENSMUST00000151160.1
 Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chr13_-_25020289 0.301 ENSMUST00000021772.2
 Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr14_+_58072686 0.295 ENSMUST00000022545.7
 Fgf9
fibroblast growth factor 9
chr4_-_123904826 0.282 ENSMUST00000181292.1
 Gm26606
predicted gene, 26606
chr8_+_75109528 0.277 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr10_-_43540945 0.265 ENSMUST00000147196.1
ENSMUST00000019932.3
 1700021F05Rik

RIKEN cDNA 1700021F05 gene

chr3_+_138526174 0.260 ENSMUST00000029803.7
 Eif4e
eukaryotic translation initiation factor 4E
chr2_+_173737492 0.233 ENSMUST00000067530.4
 Vapb
vesicle-associated membrane protein, associated protein B and C
chr7_-_105574324 0.220 ENSMUST00000081165.7
 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr4_+_123904907 0.216 ENSMUST00000106202.3
 Mycbp
c-myc binding protein
chr11_-_76763550 0.208 ENSMUST00000010536.8
 Gosr1
golgi SNAP receptor complex member 1
chr14_+_78849171 0.193 ENSMUST00000040990.5
 Vwa8
von Willebrand factor A domain containing 8
chr4_+_123904832 0.163 ENSMUST00000030400.7
 Mycbp
c-myc binding protein
chr12_-_115790884 0.162 ENSMUST00000081809.5
 Ighv1-73
immunoglobulin heavy variable 1-73
chr7_+_133637686 0.120 ENSMUST00000128901.2
 2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr7_+_133637543 0.090 ENSMUST00000051169.6
 2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr14_-_121505247 0.090 ENSMUST00000088386.6
 Slc15a1
solute carrier family 15 (oligopeptide transporter), member 1
chr9_+_122805524 0.079 ENSMUST00000052740.7
 Tcaim
T cell activation inhibitor, mitochondrial
chr5_-_107972864 0.046 ENSMUST00000153172.1
 Fam69a
family with sequence similarity 69, member A
chr9_-_54647199 0.044 ENSMUST00000128163.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr17_+_26123514 0.028 ENSMUST00000025014.8
 Mrpl28
mitochondrial ribosomal protein L28
chr2_+_177768044 0.019 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr4_-_82505749 0.013 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.5 2.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.4 2.0 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.4 3.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 0.6 GO:0009838 abscission(GO:0009838)
0.2 1.0 GO:0046078 dUMP metabolic process(GO:0046078)
0.2 1.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.2 2.1 GO:0009404 toxin metabolic process(GO:0009404)
0.2 0.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 1.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.2 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.4 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 0.2 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 2.8 GO:1901998 toxin transport(GO:1901998)
0.0 0.7 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 2.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0042938 dipeptide transport(GO:0042938)
0.0 1.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.5 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.3 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214)
0.0 0.4 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.7 GO:0003341 cilium movement(GO:0003341)
0.0 0.4 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.7 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 1.2 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.6 GO:0070652 HAUS complex(GO:0070652)
0.1 0.4 GO:0045179 apical cortex(GO:0045179)
0.1 2.0 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.6 GO:0090543 Flemming body(GO:0090543)
0.1 1.4 GO:0001741 XY body(GO:0001741)
0.0 0.6 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 2.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 3.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0030286 dynein complex(GO:0030286)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.4 1.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 1.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 2.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.7 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.7 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 2.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673) dipeptide transporter activity(GO:0042936)
0.0 2.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 2.1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 0.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.3 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination