Motif ID: Nrf1

Z-value: 3.177


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.741.3e-07Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_88751649 11.840 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr4_+_8690399 10.503 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr2_+_168081004 9.614 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr10_+_79682304 9.445 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr2_-_172370506 8.306 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr11_-_40733373 7.847 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr4_+_59581563 7.802 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr6_+_66535390 7.676 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr4_+_59581645 7.662 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr2_-_157007039 7.508 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr9_-_22389113 7.336 ENSMUST00000040912.7
 Anln
anillin, actin binding protein
chr6_+_66535418 7.315 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr5_+_36484578 7.309 ENSMUST00000060100.1
 Ccdc96
coiled-coil domain containing 96
chr17_-_53689266 7.246 ENSMUST00000024736.7
 Sgol1
shugoshin-like 1 (S. pombe)
chr2_-_157007015 6.762 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr10_+_79682169 6.757 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr13_-_53286052 6.536 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr16_-_50732707 6.508 ENSMUST00000169791.2
 5330426P16Rik
RIKEN cDNA 5330426P16 gene
chr11_+_78094660 6.426 ENSMUST00000073705.5
 Fam222b
family with sequence similarity 222, member B
chr5_+_124862674 6.423 ENSMUST00000111417.2
 Zfp664
zinc finger protein 664

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 579 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 23.6 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.6 16.1 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
1.9 15.4 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
5.1 15.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
3.7 14.7 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
3.3 13.0 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.4 12.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 11.8 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
1.7 10.5 GO:0003383 apical constriction(GO:0003383)
2.0 10.2 GO:0007403 glial cell fate determination(GO:0007403)
0.0 9.1 GO:0007283 spermatogenesis(GO:0007283)
1.5 8.9 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 8.7 GO:0007019 microtubule depolymerization(GO:0007019)
1.7 8.6 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.4 8.1 GO:0034508 centromere complex assembly(GO:0034508)
2.0 7.9 GO:0006203 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.8 7.7 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
1.5 7.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.4 7.3 GO:0043968 histone H2A acetylation(GO:0043968)
2.4 7.2 GO:1904170 regulation of bleb assembly(GO:1904170)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 228 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 40.7 GO:0000776 kinetochore(GO:0000776)
0.2 18.1 GO:0005814 centriole(GO:0005814)
1.3 17.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 16.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 15.3 GO:0000790 nuclear chromatin(GO:0000790)
3.6 14.3 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.4 13.9 GO:0090544 BAF-type complex(GO:0090544)
0.1 13.7 GO:0043296 apical junction complex(GO:0043296)
0.2 12.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 12.2 GO:0005884 actin filament(GO:0005884)
0.3 11.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 11.2 GO:0030027 lamellipodium(GO:0030027)
0.5 10.7 GO:0000242 pericentriolar material(GO:0000242)
1.5 10.5 GO:0005726 perichromatin fibrils(GO:0005726)
1.4 10.1 GO:0001940 male pronucleus(GO:0001940)
0.2 9.9 GO:0000791 euchromatin(GO:0000791)
0.5 9.7 GO:0016580 Sin3 complex(GO:0016580)
1.2 9.3 GO:0033269 internode region of axon(GO:0033269)
3.0 8.9 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.5 8.9 GO:0032433 filopodium tip(GO:0032433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 349 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 34.7 GO:0001012 RNA polymerase II regulatory region DNA binding(GO:0001012)
0.4 17.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 15.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 15.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 14.2 GO:0003697 single-stranded DNA binding(GO:0003697)
1.1 13.9 GO:0030957 Tat protein binding(GO:0030957)
0.9 13.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 12.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 12.4 GO:0042393 histone binding(GO:0042393)
0.3 11.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 11.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 10.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.5 9.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 9.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 8.6 GO:0002039 p53 binding(GO:0002039)
0.2 8.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.7 8.3 GO:0035174 histone serine kinase activity(GO:0035174)
1.3 7.6 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 7.6 GO:0046875 ephrin receptor binding(GO:0046875)
1.7 6.8 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 40.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 23.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.5 22.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.4 20.5 PID_PLK1_PATHWAY PLK1 signaling events
0.4 11.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 10.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 10.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.7 9.9 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 8.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.6 8.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 7.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.3 7.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 7.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.3 6.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.4 5.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.5 5.5 PID_ALK2_PATHWAY ALK2 signaling events
0.1 5.2 PID_E2F_PATHWAY E2F transcription factor network
0.2 5.0 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 53.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 30.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 18.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.8 16.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.8 15.9 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.3 14.2 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2 11.2 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.3 11.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5 8.1 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.3 8.0 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.8 7.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 7.6 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 7.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.6 7.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 7.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 6.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 6.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 6.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.5 6.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 5.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)