Motif ID: Obox6_Obox5

Z-value: 0.673

Transcription factors associated with Obox6_Obox5:

Gene SymbolEntrez IDGene Name
Obox5 ENSMUSG00000074366.3 Obox5
Obox6 ENSMUSG00000041583.7 Obox6



Activity profile for motif Obox6_Obox5.

activity profile for motif Obox6_Obox5


Sorted Z-values histogram for motif Obox6_Obox5

Sorted Z-values for motif Obox6_Obox5



Network of associatons between targets according to the STRING database.



First level regulatory network of Obox6_Obox5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 8.711 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr10_+_123264076 2.817 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr3_+_95526777 2.620 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr4_+_141368116 2.299 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr9_-_77347816 2.269 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr10_-_33624587 2.113 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr4_+_74013442 1.967 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chr9_-_77347787 1.773 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr11_+_104231390 1.646 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chrX_+_52791179 1.599 ENSMUST00000101588.1
 Ccdc160
coiled-coil domain containing 160
chr7_-_112159034 1.414 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr9_-_77347889 1.341 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein
chr14_-_87141206 1.190 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr16_+_17208135 1.161 ENSMUST00000169803.1
 Rimbp3
RIMS binding protein 3
chr7_-_103843154 1.022 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr13_+_110395041 1.015 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr14_+_65968483 1.013 ENSMUST00000022616.6
 Clu
clusterin
chr8_+_57455898 0.998 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr7_+_57590503 0.952 ENSMUST00000085240.4
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chrX_-_51681703 0.949 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 GO:0006413 translational initiation(GO:0006413)
0.1 4.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 2.6 GO:0030574 collagen catabolic process(GO:0030574)
0.3 1.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 1.6 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.3 1.4 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0 1.3 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.2 1.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 1.0 GO:0015671 oxygen transport(GO:0015671)
0.2 1.0 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 1.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 0.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.9 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 0.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.7 GO:0019532 oxalate transport(GO:0019532)
0.1 0.7 GO:0008272 sulfate transport(GO:0008272)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0016605 PML body(GO:0016605)
0.2 2.7 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 2.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.4 GO:0002177 manchette(GO:0002177)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.0 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.6 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.6 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.4 GO:0031983 vesicle lumen(GO:0031983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 4.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 2.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 2.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 1.9 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 1.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 1.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 1.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 1.0 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 1.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 1.0 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.8 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 0.7 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 1.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.0 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 1.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.6 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 0.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis