Motif ID: Onecut1_Cux2

Z-value: 1.058

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux2mm10_v2_chr5_-_122049822_122049882-0.797.4e-09Click!
Onecut1mm10_v2_chr9_+_74861888_748619210.529.7e-04Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 20.951 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_-_64090241 9.550 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_4755327 9.538 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr14_+_68083853 9.360 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr10_-_64090265 8.712 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_+_102010138 7.049 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr1_-_158958367 4.924 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr12_+_72441933 4.554 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr7_+_35802593 4.139 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr4_+_62965560 3.538 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr12_+_72441852 3.353 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chrX_+_134404780 2.893 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chrX_-_43274786 2.869 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr3_+_125404072 2.788 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr12_+_55598917 2.713 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr3_+_125404292 2.567 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chrX_+_134404543 2.467 ENSMUST00000113228.1
ENSMUST00000153424.1
 Drp2

dystrophin related protein 2

chr2_-_72986716 2.388 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr1_+_165302625 2.312 ENSMUST00000111450.1
 Gpr161
G protein-coupled receptor 161
chr18_-_72351009 2.121 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 21.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.2 18.3 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 9.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
3.1 9.4 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 7.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 5.3 GO:0060349 bone morphogenesis(GO:0060349)
0.7 4.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 3.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 2.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 2.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 2.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 2.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 1.9 GO:0003383 apical constriction(GO:0003383)
0.1 1.8 GO:0031507 heterochromatin assembly(GO:0031507)
0.6 1.7 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 1.6 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.2 1.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.5 1.4 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.2 1.4 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 1.2 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.7 GO:0045211 postsynaptic membrane(GO:0045211)
3.1 9.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.4 4.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 3.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.2 GO:0000792 heterochromatin(GO:0000792)
0.0 2.0 GO:0055037 recycling endosome(GO:0055037)
0.2 1.9 GO:0033269 internode region of axon(GO:0033269)
0.2 1.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.5 GO:0010369 chromocenter(GO:0010369)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.1 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.1 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.5 GO:0044308 axonal spine(GO:0044308)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.5 GO:0045298 tubulin complex(GO:0045298)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 18.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 10.5 GO:0008270 zinc ion binding(GO:0008270)
0.4 9.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 7.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.8 5.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 4.2 GO:0005042 netrin receptor activity(GO:0005042)
0.3 2.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 1.4 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 1.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 0.6 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 5.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 4.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 4.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 3.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 0.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators