Motif ID: Onecut2_Onecut3

Z-value: 0.717

Transcription factors associated with Onecut2_Onecut3:

Gene SymbolEntrez IDGene Name
Onecut2 ENSMUSG00000045991.12 Onecut2
Onecut3 ENSMUSG00000045518.8 Onecut3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut3mm10_v2_chr10_+_80494835_804948730.482.9e-03Click!
Onecut2mm10_v2_chr18_+_64340225_64340364-0.241.5e-01Click!


Activity profile for motif Onecut2_Onecut3.

activity profile for motif Onecut2_Onecut3


Sorted Z-values histogram for motif Onecut2_Onecut3

Sorted Z-values for motif Onecut2_Onecut3



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Top targets:


Showing 1 to 20 of 183 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 9.829 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_49636847 7.130 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_109545390 3.830 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr12_+_109544498 3.177 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr4_+_109343029 2.815 ENSMUST00000030281.5
 Eps15
epidermal growth factor receptor pathway substrate 15
chr6_+_5390387 2.669 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chrY_+_897782 2.353 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr9_-_86695897 2.083 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_+_102010138 2.065 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr11_+_46235460 1.774 ENSMUST00000060185.2
 Fndc9
fibronectin type III domain containing 9
chr10_-_45470201 1.698 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr4_+_145510759 1.528 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr18_+_50030977 1.400 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr17_+_79051906 1.321 ENSMUST00000040789.4
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr13_-_41273977 1.256 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr1_-_64121456 1.196 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr13_-_56895737 1.153 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chrX_+_142825698 1.087 ENSMUST00000112888.1
 Tmem164
transmembrane protein 164
chr12_+_74297474 1.049 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr1_-_170215380 1.031 ENSMUST00000027979.7
ENSMUST00000123399.1
 Uhmk1

U2AF homology motif (UHM) kinase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 7.2 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 7.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.3 2.8 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2 2.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.5 2.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.4 2.1 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 2.1 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 1.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.4 GO:0032611 interleukin-1 beta production(GO:0032611)
0.4 1.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 1.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 1.2 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.0 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 1.0 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.3 0.9 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.9 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.2 0.8 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.0 0.8 GO:0045063 T-helper 1 cell differentiation(GO:0045063)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.5 2.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.0 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.0 GO:0089701 U2AF(GO:0089701)
0.2 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 2.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.7 2.1 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 2.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 1.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 1.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.0 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 1.0 GO:0015026 coreceptor activity(GO:0015026)
0.2 0.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.9 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 0.8 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.6 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.8 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 2.2 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 1.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules