Motif ID: Osr2_Osr1

Z-value: 0.870

Transcription factors associated with Osr2_Osr1:

Gene SymbolEntrez IDGene Name
Osr1 ENSMUSG00000048387.7 Osr1
Osr2 ENSMUSG00000022330.4 Osr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Osr1mm10_v2_chr12_+_9574437_95744480.105.5e-01Click!


Activity profile for motif Osr2_Osr1.

activity profile for motif Osr2_Osr1


Sorted Z-values histogram for motif Osr2_Osr1

Sorted Z-values for motif Osr2_Osr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Osr2_Osr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 165 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_90203980 4.564 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr2_-_80128834 4.426 ENSMUST00000102654.4
ENSMUST00000102655.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr4_+_13743424 3.776 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_-_134254076 2.796 ENSMUST00000060050.5
 Grrp1
glycine/arginine rich protein 1
chr6_-_144209448 2.389 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr6_-_144209471 2.332 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr4_+_102087543 2.140 ENSMUST00000106911.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr6_-_144209558 2.066 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr3_-_89322883 1.853 ENSMUST00000029673.5
 Efna3
ephrin A3
chr7_-_57509995 1.655 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr2_+_136892168 1.621 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr6_-_59024470 1.613 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr14_-_20480106 1.533 ENSMUST00000065504.9
ENSMUST00000100844.4
 Anxa7

annexin A7

chr4_+_135963742 1.524 ENSMUST00000149636.1
ENSMUST00000143304.1
 Gale

galactose-4-epimerase, UDP

chr4_+_135963720 1.505 ENSMUST00000102541.3
 Gale
galactose-4-epimerase, UDP
chr10_-_63927434 1.461 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr6_-_59024340 1.450 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr9_-_16378231 1.374 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr19_-_41206774 1.362 ENSMUST00000025986.7
ENSMUST00000169941.1
 Tll2

tolloid-like 2

chr19_-_14598031 1.271 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 4.6 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 4.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.8 3.0 GO:0061623 glycolytic process from galactose(GO:0061623)
0.0 2.7 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 2.6 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.3 2.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 2.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 1.9 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 1.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 1.5 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 1.5 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.3 1.4 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 1.4 GO:0010842 retina layer formation(GO:0010842)
0.4 1.2 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.2 1.2 GO:0034436 glycoprotein transport(GO:0034436)
0.3 1.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 1.0 GO:0042407 cristae formation(GO:0042407)
0.2 0.9 GO:0036324 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.3 0.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 5.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 3.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.9 GO:0031430 M band(GO:0031430)
0.1 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.5 1.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 1.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 1.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 1.1 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.0 GO:0061617 MICOS complex(GO:0061617)
0.2 0.9 GO:1990032 parallel fiber(GO:1990032)
0.1 0.8 GO:0071437 invadopodium(GO:0071437)
0.1 0.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.7 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.6 GO:0097447 dendritic tree(GO:0097447)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0003714 transcription corepressor activity(GO:0003714)
1.5 4.6 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.6 4.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 3.0 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.1 2.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 1.2 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.1 1.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.4 1.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 1.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.9 GO:0005496 steroid binding(GO:0005496)
0.3 0.8 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.1 0.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.8 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.1 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 3.1 REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 2.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.5 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 0.4 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling