Motif ID: Otx1

Z-value: 0.294


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_22001631-0.429.5e-03Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_123264076 1.950 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr13_-_60897439 0.700 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr12_+_103434211 0.603 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr2_-_60963192 0.559 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr1_-_165708088 0.547 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr15_-_74734313 0.546 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr11_+_94936224 0.535 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr14_-_87141206 0.465 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr17_-_50094277 0.443 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr13_-_92030897 0.440 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr7_-_83550258 0.431 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chrX_-_167209149 0.422 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr15_-_79285502 0.418 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr5_-_104456467 0.412 ENSMUST00000069263.4
 Gm10047
predicted gene 10047
chr2_-_153225396 0.385 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr8_-_54718664 0.354 ENSMUST00000144711.2
ENSMUST00000093510.2
 Wdr17

WD repeat domain 17

chr6_-_29507946 0.349 ENSMUST00000101614.3
ENSMUST00000078112.6
 Kcp

kielin/chordin-like protein

chr7_-_79848191 0.348 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr11_-_116694802 0.311 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr14_-_87141114 0.288 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.1 0.5 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.3 GO:0097503 sialylation(GO:0097503)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 0.2 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.2 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.2 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.1 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.5 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.6 GO:0005521 lamin binding(GO:0005521)
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.1 0.2 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.0 GO:0000171 ribonuclease MRP activity(GO:0000171)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases