Motif ID: Otx1

Z-value: 0.294


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_22001631-0.429.5e-03Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_123264076 1.950 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr13_-_60897439 0.700 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr12_+_103434211 0.603 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr2_-_60963192 0.559 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr1_-_165708088 0.547 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr15_-_74734313 0.546 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr11_+_94936224 0.535 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr14_-_87141206 0.465 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr17_-_50094277 0.443 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr13_-_92030897 0.440 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr7_-_83550258 0.431 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chrX_-_167209149 0.422 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr15_-_79285502 0.418 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr5_-_104456467 0.412 ENSMUST00000069263.4
 Gm10047
predicted gene 10047
chr2_-_153225396 0.385 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr8_-_54718664 0.354 ENSMUST00000144711.2
ENSMUST00000093510.2
 Wdr17

WD repeat domain 17

chr6_-_29507946 0.349 ENSMUST00000101614.3
ENSMUST00000078112.6
 Kcp

kielin/chordin-like protein

chr7_-_79848191 0.348 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr11_-_116694802 0.311 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr14_-_87141114 0.288 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr1_+_131910458 0.242 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr7_-_118129567 0.234 ENSMUST00000032888.7
 Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr12_-_46818749 0.227 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr2_+_154656959 0.221 ENSMUST00000044277.9
 Chmp4b
charged multivesicular body protein 4B
chr19_+_4097392 0.211 ENSMUST00000174514.1
ENSMUST00000174149.1
 Cdk2ap2

CDK2-associated protein 2

chr10_+_3973086 0.202 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr10_+_127642975 0.201 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr13_+_104178797 0.188 ENSMUST00000022225.5
ENSMUST00000069187.5
 Trim23

tripartite motif-containing 23

chrX_-_95956890 0.186 ENSMUST00000079987.6
ENSMUST00000113864.2
 Las1l

LAS1-like (S. cerevisiae)

chr3_+_18054258 0.166 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr14_-_122913751 0.160 ENSMUST00000160401.1
 Ggact
gamma-glutamylamine cyclotransferase
chr13_+_21495218 0.142 ENSMUST00000104942.1
 AK157302
cDNA sequence AK157302
chr9_-_109082372 0.141 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr19_+_5024006 0.139 ENSMUST00000025826.5
 Slc29a2
solute carrier family 29 (nucleoside transporters), member 2
chr8_-_47675556 0.137 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr5_-_100373484 0.135 ENSMUST00000182433.1
 Sec31a
Sec31 homolog A (S. cerevisiae)
chr16_-_59632520 0.133 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chrM_+_10167 0.129 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr11_+_78346666 0.126 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr4_-_41517326 0.121 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr12_-_27160311 0.120 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr13_+_93771656 0.115 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr1_+_118321834 0.108 ENSMUST00000027626.6
ENSMUST00000112688.3
 Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr14_+_105258673 0.107 ENSMUST00000136040.2
 Ndfip2
Nedd4 family interacting protein 2
chr9_+_68653761 0.106 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr14_+_29968308 0.101 ENSMUST00000112268.1
 Selk
selenoprotein K
chr3_-_105960099 0.099 ENSMUST00000118209.1
 Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr10_+_29313164 0.098 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr13_+_21180179 0.097 ENSMUST00000021761.5
 Trim27
tripartite motif-containing 27
chr5_+_109923400 0.095 ENSMUST00000112544.1
 Gm15446
predicted gene 15446
chr10_+_61648552 0.093 ENSMUST00000020286.6
 Ppa1
pyrophosphatase (inorganic) 1
chr7_-_100662315 0.092 ENSMUST00000151123.1
ENSMUST00000107047.2
 Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr11_+_3963970 0.091 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr17_+_8165501 0.090 ENSMUST00000097419.3
ENSMUST00000024636.8
 Fgfr1op

Fgfr1 oncogene partner

chr3_+_66985647 0.088 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_66985947 0.084 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr13_-_55321928 0.082 ENSMUST00000035242.7
 Rab24
RAB24, member RAS oncogene family
chr11_+_103116228 0.082 ENSMUST00000053063.5
 Hexim1
hexamethylene bis-acetamide inducible 1
chr19_+_41933464 0.078 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr14_-_74947865 0.077 ENSMUST00000088970.5
 Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr11_+_115564434 0.077 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr16_+_23107754 0.075 ENSMUST00000077605.5
ENSMUST00000115341.3
 Eif4a2

eukaryotic translation initiation factor 4A2

chr6_+_145953429 0.075 ENSMUST00000111701.1
 Sspn
sarcospan
chr7_-_4063195 0.071 ENSMUST00000068865.5
ENSMUST00000086400.6
 Lair1

leukocyte-associated Ig-like receptor 1

chr5_-_5749317 0.069 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr11_+_70017085 0.068 ENSMUST00000108589.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr2_+_177897096 0.066 ENSMUST00000108935.1
 Gm14327
predicted gene 14327
chr6_+_48589560 0.066 ENSMUST00000181661.1
 Gm5111
predicted gene 5111
chr17_-_47611449 0.066 ENSMUST00000024783.8
 Bysl
bystin-like
chr13_+_41016250 0.063 ENSMUST00000021790.5
 Tmem14c
transmembrane protein 14C
chr11_+_100545607 0.060 ENSMUST00000092684.5
ENSMUST00000006976.7
 Ttc25

tetratricopeptide repeat domain 25

chr8_-_46151705 0.056 ENSMUST00000041582.8
 Snx25
sorting nexin 25
chr18_+_80206887 0.055 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr10_-_7473361 0.053 ENSMUST00000169796.2
ENSMUST00000177585.1
 Ulbp1

UL16 binding protein 1

chr7_-_100662414 0.048 ENSMUST00000079176.6
 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_-_118311132 0.048 ENSMUST00000027623.7
 Tsn
translin
chr19_-_10869757 0.043 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr7_-_38271310 0.038 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr2_+_112284561 0.036 ENSMUST00000053666.7
 Slc12a6
solute carrier family 12, member 6
chr6_-_136828186 0.032 ENSMUST00000116514.1
 Wbp11
WW domain binding protein 11
chr2_-_156180135 0.030 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr19_-_6057736 0.030 ENSMUST00000007482.6
 Mrpl49
mitochondrial ribosomal protein L49
chr10_-_93889758 0.025 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
 Metap2



methionine aminopeptidase 2



chr9_-_66975387 0.022 ENSMUST00000034929.6
 Lactb
lactamase, beta
chr5_+_15516489 0.021 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr10_-_88605017 0.018 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr2_+_129065934 0.016 ENSMUST00000035812.7
 Ttl
tubulin tyrosine ligase
chr17_+_35861343 0.016 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr7_-_104950441 0.013 ENSMUST00000179862.1
 Gm5900
predicted pseudogene 5900
chr3_+_54481429 0.013 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr7_-_30072801 0.008 ENSMUST00000183115.1
ENSMUST00000182919.1
ENSMUST00000183190.1
ENSMUST00000080834.8
 Zfp82



zinc finger protein 82



chr10_+_80054029 0.005 ENSMUST00000097227.3
 Gpx4
glutathione peroxidase 4
chrM_+_11734 0.003 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.2 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.5 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.3 GO:0097503 sialylation(GO:0097503)
0.1 0.2 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.2 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.2 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.6 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.6 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.0 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases