Motif ID: Pax2

Z-value: 1.040


Transcription factors associated with Pax2:

Gene SymbolEntrez IDGene Name
Pax2 ENSMUSG00000004231.9 Pax2



Activity profile for motif Pax2.

activity profile for motif Pax2


Sorted Z-values histogram for motif Pax2

Sorted Z-values for motif Pax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_135212557 5.299 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr1_-_82291370 4.448 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr5_-_106458440 4.324 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr4_+_148039035 4.071 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr3_+_159495408 3.722 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr4_+_148039097 3.511 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr9_-_91365778 3.229 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr12_-_101028983 3.187 ENSMUST00000068411.3
ENSMUST00000085096.3
 Ccdc88c

coiled-coil domain containing 88C

chr7_-_37773555 3.181 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr10_+_41519493 3.140 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr9_-_91365756 3.129 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr6_+_113531675 2.964 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr12_-_102878406 2.637 ENSMUST00000045652.6
 Btbd7
BTB (POZ) domain containing 7
chr1_+_106171752 2.594 ENSMUST00000061047.6
 Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
chr5_+_64803513 2.536 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr2_+_84839395 2.204 ENSMUST00000146816.1
ENSMUST00000028469.7
 Slc43a1

solute carrier family 43, member 1

chr6_-_6217023 2.139 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr19_-_7105729 2.103 ENSMUST00000113383.2
 Flrt1
fibronectin leucine rich transmembrane protein 1
chr11_-_101171302 2.052 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr11_+_70000578 2.039 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.6 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 6.3 GO:0007628 adult walking behavior(GO:0007628)
0.9 5.3 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
1.0 5.1 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.3 5.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.4 4.3 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.1 4.3 GO:0001709 cell fate determination(GO:0001709)
0.9 3.7 GO:0010288 response to lead ion(GO:0010288)
0.1 3.2 GO:0031648 protein destabilization(GO:0031648)
0.4 3.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.6 2.8 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.4 2.7 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.5 2.6 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) negative regulation of protein kinase C signaling(GO:0090038)
0.1 2.5 GO:0060351 endochondral ossification(GO:0001958) replacement ossification(GO:0036075) cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 2.4 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.3 GO:0060746 parental behavior(GO:0060746)
0.0 2.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.5 2.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 2.1 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.1 5.2 GO:0090544 BAF-type complex(GO:0090544)
1.5 4.4 GO:0005899 insulin receptor complex(GO:0005899)
0.9 3.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 2.8 GO:0000793 condensed chromosome(GO:0000793)
0.2 2.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.1 GO:0000502 proteasome complex(GO:0000502)
0.0 2.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.0 GO:0016235 aggresome(GO:0016235)
0.0 1.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.2 1.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 1.5 GO:0031084 BLOC-2 complex(GO:0031084)
0.3 1.5 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 1.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 1.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 1.5 GO:0010369 chromocenter(GO:0010369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.5 7.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
1.1 5.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 5.2 GO:0003682 chromatin binding(GO:0003682)
0.0 4.6 GO:0005096 GTPase activator activity(GO:0005096)
0.4 4.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 4.4 GO:0030332 cyclin binding(GO:0030332)
0.0 4.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 3.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 3.1 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 3.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 2.7 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 2.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 2.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 2.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 2.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.3 2.1 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 PID_PLK1_PATHWAY PLK1 signaling events
0.2 4.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.3 3.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.0 PID_BARD1_PATHWAY BARD1 signaling events
0.0 2.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.6 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 1.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 0.9 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 4.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 3.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 3.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 3.0 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 2.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 2.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 2.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 1.7 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.1 1.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 1.5 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.5 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 1.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1