Motif ID: Pax3

Z-value: 0.365


Transcription factors associated with Pax3:

Gene SymbolEntrez IDGene Name
Pax3 ENSMUSG00000004872.9 Pax3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax3mm10_v2_chr1_-_78196832_781968450.455.7e-03Click!


Activity profile for motif Pax3.

activity profile for motif Pax3


Sorted Z-values histogram for motif Pax3

Sorted Z-values for motif Pax3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_114474312 1.345 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr12_+_109747903 1.197 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr12_+_109540979 0.774 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3


chr14_+_51893610 0.748 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr10_-_70592782 0.584 ENSMUST00000162251.1
 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr12_+_38781093 0.546 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr7_+_30121915 0.440 ENSMUST00000098596.3
ENSMUST00000153792.1
 Zfp382

zinc finger protein 382

chr18_+_35562158 0.438 ENSMUST00000166793.1
 Matr3
matrin 3
chr12_+_38780817 0.425 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chrX_+_159840463 0.412 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1

chr11_-_88851462 0.400 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr7_+_120843551 0.384 ENSMUST00000106489.1
ENSMUST00000143279.1
 Eef2k

eukaryotic elongation factor-2 kinase

chrX_-_103623648 0.378 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr2_-_136387929 0.361 ENSMUST00000035264.2
ENSMUST00000077200.3
 Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr1_+_176814660 0.332 ENSMUST00000056773.8
ENSMUST00000027785.8
 Sdccag8

serologically defined colon cancer antigen 8

chr17_+_21691860 0.327 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr12_+_38780284 0.318 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr3_-_59262825 0.303 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr4_+_127077374 0.299 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr17_+_87107621 0.298 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chrX_-_103623704 0.286 ENSMUST00000130063.1
ENSMUST00000125419.1
 Ftx

Ftx transcript, Xist regulator (non-protein coding)

chr9_+_64235201 0.278 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr8_+_33428709 0.259 ENSMUST00000059351.7
 5930422O12Rik
RIKEN cDNA 5930422O12 gene
chr13_+_14630237 0.254 ENSMUST00000178289.1
ENSMUST00000038690.4
 AW209491

expressed sequence AW209491

chr10_+_82138253 0.244 ENSMUST00000105314.2
 AU041133
expressed sequence AU041133
chr3_+_36159522 0.197 ENSMUST00000165956.2
 D3Ertd254e
DNA segment, Chr 3, ERATO Doi 254, expressed
chr13_+_24327415 0.156 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr16_+_32877775 0.155 ENSMUST00000023489.4
ENSMUST00000171325.1
 Fyttd1

forty-two-three domain containing 1

chr8_+_71887264 0.133 ENSMUST00000034259.7
 Zfp709
zinc finger protein 709
chr11_+_3649494 0.125 ENSMUST00000093389.2
 Morc2a
microrchidia 2A
chr9_-_40346290 0.119 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_+_168230597 0.094 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr1_+_87404916 0.078 ENSMUST00000173152.1
ENSMUST00000173663.1
 Gigyf2

GRB10 interacting GYF protein 2

chr16_-_32877723 0.069 ENSMUST00000119810.1
 1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr12_+_52699297 0.040 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr16_-_88056176 0.033 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
 Grik1


glutamate receptor, ionotropic, kainate 1


chr4_-_25281801 0.031 ENSMUST00000102994.3
 Ufl1
UFM1 specific ligase 1
chr4_-_25281752 0.027 ENSMUST00000038705.7
 Ufl1
UFM1 specific ligase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1 1.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 0.2 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.1 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.1 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.0 0.7 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.0 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.1 0.2 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0071568 UFM1 transferase activity(GO:0071568)
0.0 0.1 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers