Motif ID: Pax4

Z-value: 0.416


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_78499087 1.312 ENSMUST00000017488.4
 Vtn
vitronectin
chrX_+_73192222 1.225 ENSMUST00000101486.4
 Xlr3b
X-linked lymphocyte-regulated 3B
chr15_-_88978958 1.046 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr8_-_84773381 1.036 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chrX_-_73097017 1.020 ENSMUST00000114524.2
ENSMUST00000074619.5
 Xlr3a

X-linked lymphocyte-regulated 3A

chr18_+_58836721 0.919 ENSMUST00000052907.5
 Adamts19
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
chr4_+_136357423 0.902 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chrX_+_9199865 0.877 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr9_-_58159201 0.854 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr9_+_32696005 0.843 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr4_-_88033328 0.778 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_-_125506385 0.694 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr12_-_90738438 0.691 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr13_-_101768154 0.671 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrM_+_3906 0.552 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr10_+_119992916 0.506 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr4_+_147132038 0.490 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chr9_-_103222063 0.488 ENSMUST00000170904.1
 Trf
transferrin
chr2_-_33086366 0.480 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_158666690 0.476 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr11_+_62574523 0.435 ENSMUST00000018651.7
 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr12_+_71048338 0.423 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr10_-_62792243 0.418 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr5_-_121502980 0.394 ENSMUST00000079368.3
 Adam1b
a disintegrin and metallopeptidase domain 1b
chr2_-_65238625 0.393 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
 Cobll1


Cobl-like 1


chr13_-_23430826 0.388 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr2_+_73271925 0.388 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr2_+_158667119 0.373 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr13_+_109632760 0.367 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chrX_-_8206475 0.366 ENSMUST00000089403.3
ENSMUST00000077595.5
ENSMUST00000089402.3
ENSMUST00000082320.5
 Porcn



porcupine homolog (Drosophila)



chr16_-_36666067 0.319 ENSMUST00000089620.4
 Cd86
CD86 antigen
chr2_-_168741752 0.309 ENSMUST00000029060.4
 Atp9a
ATPase, class II, type 9A
chr4_+_146610961 0.305 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr9_-_101198999 0.297 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr13_+_38204928 0.288 ENSMUST00000091641.5
ENSMUST00000178564.1
 Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr15_+_78597047 0.275 ENSMUST00000043069.5
 Cyth4
cytohesin 4
chr2_-_168741898 0.257 ENSMUST00000109176.1
ENSMUST00000178504.1
 Atp9a

ATPase, class II, type 9A

chr7_-_45366714 0.254 ENSMUST00000107779.1
 Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr13_+_75089826 0.240 ENSMUST00000022075.4
 Pcsk1
proprotein convertase subtilisin/kexin type 1
chr4_+_136284708 0.218 ENSMUST00000130223.1
 Zfp46
zinc finger protein 46
chr15_-_50889691 0.213 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr5_+_124552845 0.202 ENSMUST00000071057.7
 Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr2_+_22895482 0.200 ENSMUST00000053729.7
 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr12_-_98577940 0.198 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr1_-_88008520 0.196 ENSMUST00000040783.4
 Usp40
ubiquitin specific peptidase 40
chr3_+_95624971 0.191 ENSMUST00000058230.6
ENSMUST00000037983.4
 Ensa

endosulfine alpha

chr2_+_105904629 0.191 ENSMUST00000037499.5
 Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr12_-_80112998 0.184 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr15_+_80977765 0.177 ENSMUST00000139517.1
ENSMUST00000042506.8
ENSMUST00000137255.1
 Sgsm3


small G protein signaling modulator 3


chr15_-_79164477 0.175 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr4_+_156235999 0.163 ENSMUST00000179543.1
ENSMUST00000179886.1
 Noc2l

nucleolar complex associated 2 homolog (S. cerevisiae)

chr10_+_107271827 0.160 ENSMUST00000020057.8
ENSMUST00000105280.3
 Lin7a

lin-7 homolog A (C. elegans)

chr10_+_90071095 0.144 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_+_136518820 0.142 ENSMUST00000032335.6
 Atf7ip
activating transcription factor 7 interacting protein
chr2_+_22895583 0.138 ENSMUST00000152170.1
 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr2_+_122234749 0.130 ENSMUST00000110551.3
 Sord
sorbitol dehydrogenase
chr4_+_136284658 0.123 ENSMUST00000144217.1
 Zfp46
zinc finger protein 46
chr12_+_33314277 0.109 ENSMUST00000133549.1
 Atxn7l1
ataxin 7-like 1
chr19_-_32712287 0.099 ENSMUST00000070210.4
 Atad1
ATPase family, AAA domain containing 1
chrX_+_142227923 0.098 ENSMUST00000042329.5
 Nxt2
nuclear transport factor 2-like export factor 2
chr10_-_64090265 0.096 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr8_-_22476809 0.095 ENSMUST00000163774.1
ENSMUST00000033935.8
 Smim19

small integral membrane protein 19

chrX_+_142228177 0.093 ENSMUST00000112914.1
 Nxt2
nuclear transport factor 2-like export factor 2
chrM_+_11734 0.090 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr5_-_103100054 0.083 ENSMUST00000112848.1
 Mapk10
mitogen-activated protein kinase 10
chr7_-_144738520 0.082 ENSMUST00000118556.2
ENSMUST00000033393.8
 Ano1

anoctamin 1, calcium activated chloride channel

chr18_+_53862087 0.071 ENSMUST00000069597.6
 Csnk1g3
casein kinase 1, gamma 3
chrX_-_9662950 0.071 ENSMUST00000033519.2
 Dynlt3
dynein light chain Tctex-type 3
chr4_-_58987095 0.059 ENSMUST00000030069.6
 Ptgr1
prostaglandin reductase 1
chr4_+_150087365 0.055 ENSMUST00000094451.3
 Gpr157
G protein-coupled receptor 157
chr19_+_53140430 0.050 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr7_+_58658181 0.049 ENSMUST00000168747.1
 Atp10a
ATPase, class V, type 10A
chr10_-_67548944 0.041 ENSMUST00000075686.4
 Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr9_-_57158288 0.040 ENSMUST00000065358.7
 Commd4
COMM domain containing 4
chrX_-_75875101 0.039 ENSMUST00000114059.3
 Pls3
plastin 3 (T-isoform)
chr10_-_64090241 0.039 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr4_+_155831272 0.026 ENSMUST00000139651.1
ENSMUST00000084097.5
 Aurkaip1

aurora kinase A interacting protein 1

chr7_+_7171330 0.025 ENSMUST00000051435.7
 Zfp418
zinc finger protein 418
chr16_-_14291355 0.023 ENSMUST00000090287.3
 Myh11
myosin, heavy polypeptide 11, smooth muscle
chr5_-_116288978 0.021 ENSMUST00000050178.6
 Ccdc60
coiled-coil domain containing 60
chr3_+_20057802 0.017 ENSMUST00000002502.5
 Hltf
helicase-like transcription factor
chr7_-_144738478 0.007 ENSMUST00000121758.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr4_+_155831630 0.004 ENSMUST00000105592.1
ENSMUST00000105591.1
 Aurkaip1

aurora kinase A interacting protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1903011 negative regulation of bone development(GO:1903011)
0.2 0.8 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 0.8 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 0.7 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.1 1.3 GO:0097421 liver regeneration(GO:0097421)
0.1 1.0 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.3 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.1 0.2 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.1 0.5 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 1.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:0019405 hexitol metabolic process(GO:0006059) alditol catabolic process(GO:0019405) fructose biosynthetic process(GO:0046370)
0.0 0.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.2 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0090280 positive regulation of calcium ion import(GO:0090280)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 2.2 GO:0000800 lateral element(GO:0000800)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.5 GO:0097433 dense body(GO:0097433)
0.1 0.2 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.1 0.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.1 GO:0055037 recycling endosome(GO:0055037)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.3 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 1.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.2 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)