Motif ID: Pax4

Z-value: 0.416


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 1.312 ENSMUST00000017488.4
 Vtn
vitronectin
chrX_+_73192222 1.225 ENSMUST00000101486.4
 Xlr3b
X-linked lymphocyte-regulated 3B
chr15_-_88978958 1.046 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr8_-_84773381 1.036 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chrX_-_73097017 1.020 ENSMUST00000114524.2
ENSMUST00000074619.5
 Xlr3a

X-linked lymphocyte-regulated 3A

chr18_+_58836721 0.919 ENSMUST00000052907.5
 Adamts19
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
chr4_+_136357423 0.902 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chrX_+_9199865 0.877 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr9_-_58159201 0.854 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr9_+_32696005 0.843 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr4_-_88033328 0.778 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_-_125506385 0.694 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr12_-_90738438 0.691 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr13_-_101768154 0.671 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrM_+_3906 0.552 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr10_+_119992916 0.506 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr4_+_147132038 0.490 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chr9_-_103222063 0.488 ENSMUST00000170904.1
 Trf
transferrin
chr2_-_33086366 0.480 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_158666690 0.476 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.3 GO:0097421 liver regeneration(GO:0097421)
0.1 1.0 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.1 1.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 0.8 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 0.8 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 0.7 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.7 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.1 0.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.5 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.3 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0000800 lateral element(GO:0000800)
0.0 2.1 GO:0055037 recycling endosome(GO:0055037)
0.3 1.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.5 GO:0097433 dense body(GO:0097433)
0.0 0.4 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.2 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 0.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.3 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.2 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)