Motif ID: Pax6

Z-value: 0.738


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.891.0e-13Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_57118981 6.122 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr19_-_57118897 5.258 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr11_-_95587691 3.095 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chrX_+_103422010 3.043 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr3_+_65109343 3.005 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr4_+_85205417 2.397 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr1_-_38836090 2.200 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr8_-_57962564 1.980 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr18_-_34373313 1.797 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr15_-_101850778 1.681 ENSMUST00000023790.3
 Krt1
keratin 1
chr6_-_60829826 1.645 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr2_-_162661075 1.620 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr7_-_12775658 1.452 ENSMUST00000046245.5
 Zscan18
zinc finger and SCAN domain containing 18
chr3_-_89245005 1.322 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46
chr3_-_89245159 1.298 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr15_+_84669565 1.277 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr13_-_110280103 1.271 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr10_+_80356459 1.211 ENSMUST00000039836.8
ENSMUST00000105351.1
 Plk5

polo-like kinase 5

chr5_+_90903864 1.169 ENSMUST00000075433.6
 Cxcl2
chemokine (C-X-C motif) ligand 2
chr13_+_64432479 1.116 ENSMUST00000021939.6
 Cdk20
cyclin-dependent kinase 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.4 GO:0030032 lamellipodium assembly(GO:0030032)
1.0 3.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.2 3.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.3 2.6 GO:0099612 protein localization to axon(GO:0099612)
0.0 2.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 2.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 2.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.3 1.8 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 1.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 1.6 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.1 1.3 GO:0038203 TORC2 signaling(GO:0038203)
0.0 1.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 1.2 GO:0002347 response to tumor cell(GO:0002347)
0.1 1.2 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.3 1.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 1.1 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.3 1.0 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 1.0 GO:0007601 visual perception(GO:0007601)
0.3 0.9 GO:0097274 urea homeostasis(GO:0097274)
0.2 0.8 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 3.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 3.0 GO:1990635 proximal dendrite(GO:1990635)
0.7 2.6 GO:1990769 proximal neuron projection(GO:1990769)
0.5 1.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 1.7 GO:0001533 cornified envelope(GO:0001533)
0.4 1.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.3 GO:0031932 TORC2 complex(GO:0031932)
0.3 0.8 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0044613 nuclear pore central transport channel(GO:0044613)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 GO:0003779 actin binding(GO:0003779)
0.3 3.1 GO:0048406 neurotrophin TRKA receptor binding(GO:0005168) nerve growth factor binding(GO:0048406)
0.2 3.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.4 2.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 2.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.8 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.3 GO:0031489 myosin V binding(GO:0031489)
0.1 1.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.4 1.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 1.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 1.0 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 0.8 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 0.7 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.2 0.6 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.6 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)
0.2 0.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 2.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.2 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 1.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 0.7 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 3.1 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 3.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 2.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 1.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 1.1 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 1.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 0.7 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor