Motif ID: Pax8

Z-value: 0.448


Transcription factors associated with Pax8:

Gene SymbolEntrez IDGene Name
Pax8 ENSMUSG00000026976.9 Pax8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax8mm10_v2_chr2_-_24475596_244756050.202.4e-01Click!


Activity profile for motif Pax8.

activity profile for motif Pax8


Sorted Z-values histogram for motif Pax8

Sorted Z-values for motif Pax8



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_42578588 2.359 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr7_+_112742025 1.858 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chr1_+_6487231 1.846 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr3_+_135212557 1.808 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr18_-_12121460 1.357 ENSMUST00000055447.6
ENSMUST00000050228.7
ENSMUST00000092075.4
 Tmem241


transmembrane protein 241


chr11_-_69801716 1.047 ENSMUST00000011285.4
ENSMUST00000102585.1
 Fgf11

fibroblast growth factor 11

chr13_-_62607499 0.935 ENSMUST00000091563.4
 6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr7_+_114768736 0.742 ENSMUST00000117543.1
 Insc
inscuteable homolog (Drosophila)
chr7_+_107595051 0.692 ENSMUST00000040056.7
 Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr7_-_42706369 0.658 ENSMUST00000180131.1
 Gm17067
predicted gene 17067
chrX_-_105391726 0.654 ENSMUST00000142109.1
 5330434G04Rik
RIKEN cDNA 5330434G04 gene
chr13_-_62520451 0.574 ENSMUST00000082203.6
ENSMUST00000101547.4
 Zfp934

zinc finger protein 934

chr13_+_108214389 0.540 ENSMUST00000022207.8
 Elovl7
ELOVL family member 7, elongation of long chain fatty acids (yeast)
chr2_+_177508570 0.463 ENSMUST00000108940.2
 Gm14403
predicted gene 14403
chr12_+_71048338 0.447 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr17_+_45555693 0.429 ENSMUST00000024742.7
 Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chr1_+_65186727 0.404 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chrX_-_105391770 0.376 ENSMUST00000136406.1
ENSMUST00000150604.1
 5330434G04Rik

RIKEN cDNA 5330434G04 gene

chr13_-_62777089 0.299 ENSMUST00000167516.2
 Gm5141
predicted gene 5141
chr4_+_6191093 0.289 ENSMUST00000029907.5
 Ubxn2b
UBX domain protein 2B
chr5_+_100196611 0.280 ENSMUST00000066813.1
 Gm9932
predicted gene 9932
chr2_+_143915273 0.215 ENSMUST00000103172.3
 Dstn
destrin
chr12_+_84996487 0.191 ENSMUST00000101202.3
 Ylpm1
YLP motif containing 1
chr4_+_59805829 0.174 ENSMUST00000030080.6
 Snx30
sorting nexin family member 30
chr9_-_103230262 0.173 ENSMUST00000165296.1
ENSMUST00000112645.1
ENSMUST00000166836.1
 Trf

Gm20425
transferrin

predicted gene 20425
chr17_+_21691860 0.102 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr7_+_12897800 0.101 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr1_+_74542881 0.099 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
 Plcd4




phospholipase C, delta 4




chr4_+_156215920 0.064 ENSMUST00000105572.1
 2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr10_+_18845071 0.057 ENSMUST00000019998.7
 Perp
PERP, TP53 apoptosis effector
chr12_-_20900867 0.050 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chr16_-_17125106 0.045 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr2_-_150255591 0.040 ENSMUST00000063463.5
 Gm21994
predicted gene 21994
chr2_+_128967383 0.036 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chrX_-_7572843 0.035 ENSMUST00000132788.1
 Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr9_-_103230415 0.026 ENSMUST00000035158.9
 Trf
transferrin
chr5_-_137307633 0.023 ENSMUST00000040873.7
 Srrt
serrate RNA effector molecule homolog (Arabidopsis)
chr8_+_60655540 0.019 ENSMUST00000034066.3
 Mfap3l
microfibrillar-associated protein 3-like
chr16_+_34784917 0.003 ENSMUST00000023538.8
 Mylk
myosin, light polypeptide kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.3 1.4 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.2 1.9 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 1.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 0.4 GO:0032329 serine transport(GO:0032329)
0.1 0.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.5 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.7 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.4 GO:0032288 myelin assembly(GO:0032288)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 1.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0043515 kinetochore binding(GO:0043515)
0.2 1.4 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 1.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 0.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.5 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs