Motif ID: Pbx1_Pbx3

Z-value: 1.465

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx3mm10_v2_chr2_-_34372004_343720440.741.3e-07Click!
Pbx1mm10_v2_chr1_-_168432270_168432347-0.546.0e-04Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_15463837 8.897 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr18_-_84086379 8.213 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr11_-_19018956 8.148 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chrX_+_58030622 7.886 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr19_+_55741810 7.370 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr3_+_127633134 7.127 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr4_-_3938354 6.891 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr11_-_84068554 6.525 ENSMUST00000164891.1
 Dusp14
dual specificity phosphatase 14
chr11_-_19018714 6.231 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr4_+_144892813 6.200 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr11_-_22001605 6.148 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr11_-_84068766 5.976 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr11_-_84069179 5.935 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chrX_-_109013389 5.189 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr4_+_59581563 5.132 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr4_+_59581645 5.071 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr14_-_122465677 5.047 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr3_-_8667033 4.953 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr19_-_9899450 4.843 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr17_-_70853482 4.839 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 21.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
2.1 16.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.8 16.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.7 11.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.2 9.2 GO:0048852 diencephalon morphogenesis(GO:0048852)
3.0 8.9 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.0 8.6 GO:0055114 oxidation-reduction process(GO:0055114)
2.7 8.2 GO:0060023 soft palate development(GO:0060023)
1.3 7.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.5 6.9 GO:0060736 prostate gland growth(GO:0060736)
0.0 5.1 GO:0001843 neural tube closure(GO:0001843)
1.2 5.0 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.5 4.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.2 4.7 GO:0036010 protein localization to endosome(GO:0036010)
0.0 4.4 GO:0048469 cell maturation(GO:0048469)
0.0 4.3 GO:0000910 cytokinesis(GO:0000910)
0.3 4.1 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.3 3.9 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.5 3.8 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
1.1 3.4 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 16.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 15.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 8.9 GO:0016592 mediator complex(GO:0016592)
0.6 7.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 6.9 GO:0016607 nuclear speck(GO:0016607)
1.6 4.8 GO:0000801 central element(GO:0000801)
0.0 4.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.1 GO:0001726 ruffle(GO:0001726)
0.4 3.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 3.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.3 3.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 3.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 3.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.1 GO:0005871 kinesin complex(GO:0005871)
0.5 3.0 GO:0031262 Ndc80 complex(GO:0031262)
0.0 3.0 GO:0000786 nucleosome(GO:0000786)
0.7 2.8 GO:0008623 CHRAC(GO:0008623)
0.3 2.6 GO:0072687 meiotic spindle(GO:0072687)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 2.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.2 17.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.8 16.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 13.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 9.7 GO:0016491 oxidoreductase activity(GO:0016491)
0.2 7.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 7.1 GO:0070888 E-box binding(GO:0070888)
0.2 7.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.9 6.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.7 5.0 GO:0035939 microsatellite binding(GO:0035939)
0.1 4.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 4.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 4.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.3 3.8 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 3.5 GO:0032452 histone demethylase activity(GO:0032452)
0.1 3.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 3.4 GO:0005112 Notch binding(GO:0005112)
0.0 3.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 3.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 3.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 14.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 11.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 8.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 6.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 6.6 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 3.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 2.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.0 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 0.9 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 7.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 4.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 3.8 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 3.4 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 3.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 3.3 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 3.1 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.3 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.9 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.2 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 0.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors