Motif ID: Pgr_Nr3c1
Z-value: 0.480
Transcription factors associated with Pgr_Nr3c1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr3c1 | ENSMUSG00000024431.8 | Nr3c1 |
Pgr | ENSMUSG00000031870.10 | Pgr |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nr3c1 | mm10_v2_chr18_-_39487096_39487245 | 0.43 | 8.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 8.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.5 | 1.6 | GO:0003100 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
0.5 | 1.9 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
0.3 | 1.0 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.3 | 0.6 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
0.3 | 0.8 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
0.2 | 1.7 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
0.2 | 0.8 | GO:1904048 | negative regulation of synaptic vesicle recycling(GO:1903422) regulation of spontaneous neurotransmitter secretion(GO:1904048) |
0.1 | 0.4 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
0.1 | 0.3 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
0.1 | 0.6 | GO:0033024 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
0.1 | 1.0 | GO:0014819 | regulation of skeletal muscle contraction(GO:0014819) |
0.1 | 0.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.1 | 0.6 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
0.1 | 0.4 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
0.1 | 0.5 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
0.1 | 0.2 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044) |
0.1 | 0.2 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
0.1 | 0.2 | GO:0002946 | tRNA C5-cytosine methylation(GO:0002946) |
0.1 | 1.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.1 | 0.3 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) |
0.1 | 1.0 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
0.0 | 0.5 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
0.0 | 0.2 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
0.0 | 0.4 | GO:0043615 | astrocyte cell migration(GO:0043615) |
0.0 | 0.4 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
0.0 | 0.1 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
0.0 | 0.2 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.0 | 0.4 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
0.0 | 0.1 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
0.0 | 0.3 | GO:0034088 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
0.0 | 0.2 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
0.0 | 0.1 | GO:0000429 | carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) |
0.0 | 0.2 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
0.0 | 0.3 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
0.0 | 0.0 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) |
0.0 | 0.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
0.0 | 0.4 | GO:0001945 | lymph vessel development(GO:0001945) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.9 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
0.2 | 1.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.1 | 0.8 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
0.1 | 0.3 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
0.0 | 1.9 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
0.0 | 1.0 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
0.0 | 0.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
0.0 | 0.3 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 1.6 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.2 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.0 | 0.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
0.0 | 0.3 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
0.0 | 1.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.2 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 1.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 8.7 | GO:0070324 | thyroid hormone binding(GO:0070324) |
0.5 | 1.6 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
0.1 | 0.6 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
0.1 | 1.0 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
0.1 | 0.3 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.1 | 0.6 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
0.1 | 0.4 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.1 | 0.2 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
0.1 | 1.0 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
0.1 | 0.7 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.1 | 1.0 | GO:0030275 | LRR domain binding(GO:0030275) |
0.1 | 0.5 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
0.0 | 0.2 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
0.0 | 0.7 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
0.0 | 3.1 | GO:0005518 | collagen binding(GO:0005518) |
0.0 | 0.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.0 | 0.2 | GO:0045340 | mercury ion binding(GO:0045340) |
0.0 | 0.5 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
0.0 | 0.5 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
0.0 | 0.8 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
0.0 | 0.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
0.0 | 0.4 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.0 | 1.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 0.2 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
0.0 | 0.3 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
0.0 | 0.2 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
0.0 | 0.1 | GO:0004065 | arylsulfatase activity(GO:0004065) |
0.0 | 0.9 | GO:0001671 | ATPase activator activity(GO:0001671) |
0.0 | 0.1 | GO:0033142 | progesterone receptor binding(GO:0033142) |
0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.0 | 0.1 | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242) |
0.0 | 0.2 | GO:0050815 | phosphoserine binding(GO:0050815) |
0.0 | 0.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.0 | 0.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.0 | 0.2 | GO:0031402 | sodium ion binding(GO:0031402) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 8.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 3.9 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.1 | 1.6 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.1 | 1.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 0.6 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
0.0 | 0.9 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 0.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 0.2 | PID_LYMPH_ANGIOGENESIS_PATHWAY | VEGFR3 signaling in lymphatic endothelium |
0.0 | 2.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.0 | PID_FGF_PATHWAY | FGF signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.5 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.2 | 1.9 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
0.2 | 8.7 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
0.1 | 1.6 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
0.1 | 0.8 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
0.1 | 3.9 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.1 | 0.2 | REACTOME_BOTULINUM_NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
0.0 | 0.7 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 1.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 0.3 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.0 | 0.6 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 1.0 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 1.7 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 0.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 0.1 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.0 | 0.2 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
0.0 | 0.2 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.0 | 0.3 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
0.0 | 0.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.6 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
0.0 | 0.2 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
0.0 | 0.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 0.2 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |