Motif ID: Pgr_Nr3c1

Z-value: 0.480

Transcription factors associated with Pgr_Nr3c1:

Gene SymbolEntrez IDGene Name
Nr3c1 ENSMUSG00000024431.8 Nr3c1
Pgr ENSMUSG00000031870.10 Pgr

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr3c1mm10_v2_chr18_-_39487096_394872450.438.5e-03Click!


Activity profile for motif Pgr_Nr3c1.

activity profile for motif Pgr_Nr3c1


Sorted Z-values histogram for motif Pgr_Nr3c1

Sorted Z-values for motif Pgr_Nr3c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pgr_Nr3c1

PNG image of the network

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Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 8.722 ENSMUST00000075312.3
 Ttr
transthyretin
chr13_-_84064772 4.151 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr10_+_97565436 1.891 ENSMUST00000038160.4
 Lum
lumican
chr14_+_99298652 1.654 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5
chr5_+_24364804 1.619 ENSMUST00000030834.4
ENSMUST00000115090.1
 Nos3

nitric oxide synthase 3, endothelial cell

chr4_-_136898803 1.509 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr9_-_79718631 1.455 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718518 1.287 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr5_-_104114088 1.200 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr9_-_79718720 1.173 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr14_+_70555900 1.006 ENSMUST00000163060.1
 Hr
hairless
chr11_+_111066154 0.959 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_-_152193803 0.878 ENSMUST00000050073.6
 Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr5_-_123140135 0.846 ENSMUST00000160099.1
 AI480526
expressed sequence AI480526
chr7_-_127824469 0.831 ENSMUST00000106267.3
 Stx1b
syntaxin 1B
chr13_+_29016267 0.824 ENSMUST00000140415.1
 A330102I10Rik
RIKEN cDNA A330102I10 gene
chr2_-_122611238 0.811 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr2_+_65620829 0.786 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr11_-_110168073 0.724 ENSMUST00000044850.3
 Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr10_-_116473418 0.710 ENSMUST00000087965.4
ENSMUST00000164271.1
 Kcnmb4

potassium large conductance calcium-activated channel, subfamily M, beta member 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 8.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 1.9 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 1.7 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.5 1.6 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 1.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 1.0 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 1.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.1 1.0 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.9 GO:0005513 detection of calcium ion(GO:0005513)
0.3 0.8 GO:0006601 creatine biosynthetic process(GO:0006601)
0.2 0.8 GO:1904048 negative regulation of synaptic vesicle recycling(GO:1903422) regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.3 0.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.6 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 0.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.5 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.1 0.4 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.1 0.4 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.4 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.4 GO:2000653 regulation of genetic imprinting(GO:2000653)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.9 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.2 1.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.3 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 3.1 GO:0005518 collagen binding(GO:0005518)
0.5 1.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.0 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.0 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.9 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.8 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.7 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.6 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 3.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 1.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 1.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 0.2 REACTOME_BOTULINUM_NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation