Motif ID: Pitx1
Z-value: 0.820
Transcription factors associated with Pitx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pitx1 | ENSMUSG00000021506.7 | Pitx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.5 | GO:0003383 | apical constriction(GO:0003383) |
| 0.8 | 2.5 | GO:0072554 | blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.8 | 5.7 | GO:0044838 | cell quiescence(GO:0044838) |
| 0.7 | 2.6 | GO:0003360 | brainstem development(GO:0003360) |
| 0.6 | 0.6 | GO:0060853 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101) |
| 0.6 | 6.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.5 | 1.1 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.5 | 2.6 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.5 | 1.9 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 0.5 | 2.8 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.5 | 3.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.5 | 2.3 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
| 0.4 | 1.3 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 0.4 | 2.0 | GO:0061642 | chemoattraction of axon(GO:0061642) |
| 0.3 | 1.0 | GO:0002865 | immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) |
| 0.3 | 2.7 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.3 | 1.1 | GO:1904778 | regulation of metaphase plate congression(GO:0090235) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.3 | 1.1 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.2 | 2.5 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.2 | 3.0 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 1.5 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.2 | 1.0 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.2 | 1.2 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.2 | 0.8 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.2 | 0.6 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.2 | 0.7 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.2 | 0.5 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913) |
| 0.2 | 0.5 | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.2 | 1.3 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 0.4 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 0.1 | 0.8 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.1 | 0.4 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.1 | 0.6 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.1 | 1.2 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.1 | 2.9 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.1 | 0.6 | GO:0072235 | distal convoluted tubule development(GO:0072025) metanephric collecting duct development(GO:0072205) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) |
| 0.1 | 0.9 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.1 | 1.1 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.1 | 1.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.7 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 0.5 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 0.8 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 0.8 | GO:0070072 | vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.1 | 0.2 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.1 | 0.5 | GO:0030242 | pexophagy(GO:0030242) |
| 0.1 | 0.2 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.9 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.1 | 0.2 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.1 | 1.5 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.1 | 2.1 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.1 | 0.8 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 0.3 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.1 | 0.2 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.0 | 0.2 | GO:0050748 | negative regulation of lipoprotein metabolic process(GO:0050748) |
| 0.0 | 0.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 0.2 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.0 | 0.1 | GO:0001757 | somite specification(GO:0001757) |
| 0.0 | 0.2 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.0 | 1.1 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.0 | 1.0 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.2 | GO:1904017 | positive regulation of female receptivity(GO:0045925) response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.0 | 1.0 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.0 | 1.1 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.0 | 8.2 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.0 | 0.8 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
| 0.0 | 0.1 | GO:0035993 | extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) deltoid tuberosity development(GO:0035993) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) |
| 0.0 | 0.4 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.3 | GO:1902170 | cellular response to reactive nitrogen species(GO:1902170) |
| 0.0 | 0.1 | GO:2001015 | skeletal muscle satellite cell activation(GO:0014719) G1 to G0 transition involved in cell differentiation(GO:0070315) negative regulation of skeletal muscle cell differentiation(GO:2001015) |
| 0.0 | 0.1 | GO:1904978 | regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980) |
| 0.0 | 0.1 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.0 | 0.1 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.0 | 0.9 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 0.1 | GO:0086028 | bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) |
| 0.0 | 0.5 | GO:0010955 | negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318) |
| 0.0 | 1.6 | GO:0045580 | regulation of T cell differentiation(GO:0045580) |
| 0.0 | 0.1 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 0.0 | 0.4 | GO:0009649 | entrainment of circadian clock(GO:0009649) |
| 0.0 | 0.2 | GO:0035855 | megakaryocyte development(GO:0035855) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.9 | 2.6 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.8 | 6.5 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.4 | 1.3 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.3 | 1.1 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.2 | 1.9 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.2 | 0.8 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.2 | 3.1 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 1.6 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 2.5 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 7.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 2.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 0.9 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 2.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.5 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.1 | 1.4 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 3.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 1.4 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 1.0 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.3 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.1 | 0.8 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 1.7 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 0.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.2 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.0 | 0.2 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 2.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 6.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 1.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.3 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.2 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.5 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.6 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 3.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 2.2 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 1.0 | GO:0030016 | myofibril(GO:0030016) |
| 0.0 | 1.1 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.1 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 1.1 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.7 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.8 | 5.5 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.7 | 2.9 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.5 | 3.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.5 | 2.0 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.4 | 2.6 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.3 | 1.4 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 0.3 | 1.0 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.3 | 2.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.3 | 0.9 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.3 | 1.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.3 | 5.4 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.3 | 2.6 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.3 | 0.8 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.3 | 1.0 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.2 | 2.8 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 1.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.2 | 1.2 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.2 | 3.4 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 1.1 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.2 | 0.8 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 1.0 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.2 | 1.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.2 | 7.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.4 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.1 | 0.6 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.1 | 1.1 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 0.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 3.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 2.0 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 0.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 2.3 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.1 | 0.8 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 0.7 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 0.6 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.0 | 2.0 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.6 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 0.2 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.0 | 0.2 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.0 | 0.8 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.4 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.2 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 2.8 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.5 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 2.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.6 | GO:0019842 | vitamin binding(GO:0019842) |
| 0.0 | 0.1 | GO:0031432 | titin binding(GO:0031432) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.9 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
| 0.4 | 1.1 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.2 | 3.0 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.1 | 5.7 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 6.3 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 1.6 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 6.5 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 0.4 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 1.2 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 3.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.3 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.5 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.8 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.7 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.2 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.3 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 1.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.9 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.3 | 3.2 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 6.5 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 1.1 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 2.0 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 2.8 | REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION | Genes involved in Incretin Synthesis, Secretion, and Inactivation |
| 0.1 | 5.7 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 1.1 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 1.0 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 2.6 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 0.7 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 0.8 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 4.1 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.4 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.0 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.0 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 1.2 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.9 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.6 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.2 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.3 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 1.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.2 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.2 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
