Motif ID: Pitx1

Z-value: 0.820


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 194 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_93913678 5.393 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr13_-_97747373 4.382 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 4.323 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_46010212 3.904 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_-_92165159 3.854 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr1_-_155232710 3.734 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr8_+_127064022 3.368 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr2_+_102658640 3.274 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_+_127063893 3.155 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr7_-_4752972 3.051 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr5_+_3343893 2.952 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr17_+_75005523 2.931 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr4_-_155010984 2.858 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr14_-_118052235 2.830 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr5_+_3344194 2.770 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr14_-_54926784 2.731 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr4_-_41697040 2.619 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr14_-_31640878 2.592 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
 Hacl1


2-hydroxyacyl-CoA lyase 1


chr2_+_119325784 2.550 ENSMUST00000102517.3
 Dll4
delta-like 4 (Drosophila)
chr4_+_116708687 2.395 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0016042 lipid catabolic process(GO:0016042)
1.1 6.5 GO:0003383 apical constriction(GO:0003383)
0.6 6.3 GO:0042572 retinol metabolic process(GO:0042572)
0.8 5.7 GO:0044838 cell quiescence(GO:0044838)
0.5 3.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 3.0 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1 2.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.5 2.8 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 2.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.7 2.6 GO:0003360 brainstem development(GO:0003360)
0.5 2.6 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.8 2.5 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.2 2.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.5 2.3 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.1 2.1 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.4 2.0 GO:0061642 chemoattraction of axon(GO:0061642)
0.5 1.9 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087)
0.0 1.6 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.2 1.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.5 GO:0040034 regulation of development, heterochronic(GO:0040034)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.8 6.5 GO:0033269 internode region of axon(GO:0033269)
0.0 6.0 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.3 GO:0030673 axolemma(GO:0030673)
0.2 3.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 3.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 2.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 2.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 2.7 GO:0010369 chromocenter(GO:0010369)
0.0 2.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.9 2.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 2.5 GO:0097470 ribbon synapse(GO:0097470)
0.0 2.2 GO:0030425 dendrite(GO:0030425)
0.2 1.9 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 1.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 1.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.4 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.4 GO:0035253 ciliary rootlet(GO:0035253)
0.4 1.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.9 5.7 GO:0098770 FBXO family protein binding(GO:0098770)
0.8 5.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 5.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 3.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.5 3.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 3.2 GO:0005112 Notch binding(GO:0005112)
0.7 2.9 GO:0050436 microfibril binding(GO:0050436)
0.2 2.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 2.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.4 2.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.3 2.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.3 2.5 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 2.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.5 2.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 2.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 2.0 GO:0030332 cyclin binding(GO:0030332)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.2 1.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 6.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 3.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 3.0 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.4 1.9 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 1.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 1.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 5.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 3.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.8 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 2.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.2 2.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.6 1.9 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 1.1 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.1 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.0 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants