Motif ID: Pitx2_Otx2

Z-value: 1.413

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pitx2mm10_v2_chr3_+_129199960_129199975-0.719.9e-07Click!
Otx2mm10_v2_chr14_-_48667508_486676440.289.5e-02Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_88898664 7.585 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr4_-_117182623 5.685 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr9_-_70421533 5.370 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr7_-_75782080 5.202 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr11_-_106998483 4.576 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr6_+_56017489 4.461 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr4_+_80910646 4.374 ENSMUST00000055922.3
 Lurap1l
leucine rich adaptor protein 1-like
chr14_-_47411666 4.019 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr6_+_34354119 3.751 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr8_+_127447669 3.718 ENSMUST00000159511.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr11_-_84068766 3.659 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr11_-_84068554 3.582 ENSMUST00000164891.1
 Dusp14
dual specificity phosphatase 14
chr18_+_34751803 3.412 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr7_+_16992708 3.362 ENSMUST00000094805.4
 Ccdc8
coiled-coil domain containing 8
chr11_-_84069179 3.342 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chr18_-_74207771 3.312 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr14_-_47418407 3.292 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr11_+_101448403 3.175 ENSMUST00000010502.6
 Ifi35
interferon-induced protein 35
chr3_-_36571952 3.165 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr10_-_128180265 3.124 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 351 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.8 7.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 7.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 7.0 GO:0010921 regulation of phosphatase activity(GO:0010921)
1.1 5.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 5.1 GO:0048538 thymus development(GO:0048538)
0.1 4.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 3.9 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
1.3 3.8 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.6 3.8 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.6 3.7 GO:0003383 apical constriction(GO:0003383)
0.0 3.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 3.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 3.3 GO:0009060 aerobic respiration(GO:0009060)
0.1 3.2 GO:0016572 histone phosphorylation(GO:0016572)
0.2 2.9 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 2.7 GO:0033504 floor plate development(GO:0033504)
0.1 2.7 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 2.6 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 2.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 7.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 7.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 7.3 GO:0005643 nuclear pore(GO:0005643)
0.2 7.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 6.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 5.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 5.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 5.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.7 4.6 GO:0001940 male pronucleus(GO:0001940)
0.5 3.7 GO:0033269 internode region of axon(GO:0033269)
0.1 3.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.6 3.4 GO:1990393 3M complex(GO:1990393)
0.3 3.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 3.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 2.7 GO:0031105 septin complex(GO:0031105)
0.1 2.6 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 2.5 GO:0016459 myosin complex(GO:0016459)
0.2 2.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 245 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.9 12.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 7.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 7.0 GO:0045296 cadherin binding(GO:0045296)
0.2 6.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 6.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.3 5.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.6 5.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 4.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 4.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.8 3.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 3.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 3.0 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 2.9 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.2 2.7 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 2.7 GO:0016805 dipeptidase activity(GO:0016805)
0.2 2.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 2.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.7 PID_ATR_PATHWAY ATR signaling pathway
0.3 7.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 7.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 5.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.2 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 4.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 4.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.8 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.5 PID_MYC_PATHWAY C-MYC pathway
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 1.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.4 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 1.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.1 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.5 8.5 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 8.5 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.5 7.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 7.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 7.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 5.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 5.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 4.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 4.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 3.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.9 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 2.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 2.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 2.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 1.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.8 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 1.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA