Motif ID: Pitx3
Z-value: 0.631
Transcription factors associated with Pitx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pitx3 | ENSMUSG00000025229.9 | Pitx3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.3 | GO:1902256 | endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 0.7 | 3.4 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.5 | 3.0 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.4 | 1.1 | GO:0030210 | heparin biosynthetic process(GO:0030210) |
| 0.4 | 1.1 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) interleukin-1 alpha secretion(GO:0050703) regulation of bleb assembly(GO:1904170) |
| 0.3 | 1.7 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
| 0.3 | 1.0 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.3 | 1.6 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.3 | 0.9 | GO:0002865 | immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) |
| 0.3 | 0.8 | GO:0042732 | D-xylose metabolic process(GO:0042732) |
| 0.3 | 1.4 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.3 | 1.3 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.2 | 0.7 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.2 | 0.7 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 0.2 | 0.7 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.2 | 0.7 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.2 | 0.2 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.2 | 1.0 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.2 | 1.1 | GO:0003383 | apical constriction(GO:0003383) |
| 0.2 | 0.7 | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362) |
| 0.2 | 0.7 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
| 0.2 | 0.7 | GO:1902990 | mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 0.2 | 0.5 | GO:0042560 | 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.2 | 0.5 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 0.5 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.2 | 0.9 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.2 | 0.6 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) |
| 0.1 | 1.0 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 0.4 | GO:0016598 | protein arginylation(GO:0016598) |
| 0.1 | 0.1 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
| 0.1 | 0.4 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) |
| 0.1 | 0.7 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
| 0.1 | 0.8 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.1 | 1.0 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.1 | 0.4 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.1 | 0.4 | GO:0090646 | RNA 5'-end processing(GO:0000966) mitochondrial tRNA processing(GO:0090646) |
| 0.1 | 0.6 | GO:0021764 | amygdala development(GO:0021764) |
| 0.1 | 0.7 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.1 | 0.4 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
| 0.1 | 0.3 | GO:1905223 | epicardium morphogenesis(GO:1905223) |
| 0.1 | 0.5 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 0.7 | GO:0044838 | germ-line stem cell population maintenance(GO:0030718) cell quiescence(GO:0044838) |
| 0.1 | 0.3 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.1 | 0.3 | GO:0048698 | negative regulation of collateral sprouting in absence of injury(GO:0048698) |
| 0.1 | 0.3 | GO:0006667 | sphinganine metabolic process(GO:0006667) regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504) |
| 0.1 | 0.4 | GO:0097694 | leptotene(GO:0000237) establishment of RNA localization to telomere(GO:0097694) |
| 0.1 | 0.6 | GO:0070814 | hydrogen sulfide biosynthetic process(GO:0070814) |
| 0.1 | 1.3 | GO:0097502 | mannosylation(GO:0097502) |
| 0.1 | 2.1 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.1 | 0.6 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.1 | 0.4 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.1 | 0.3 | GO:1990743 | protein sialylation(GO:1990743) |
| 0.1 | 0.3 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 0.2 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.1 | 0.2 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.1 | 0.6 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.1 | 0.2 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 0.1 | 0.4 | GO:0036337 | Fas signaling pathway(GO:0036337) |
| 0.1 | 0.5 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.1 | 0.3 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.1 | 0.4 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 0.1 | 0.6 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 0.3 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.1 | 0.3 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.1 | 0.3 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.1 | 0.6 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.1 | 0.2 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.1 | 0.2 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
| 0.1 | 0.2 | GO:1904975 | response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976) |
| 0.1 | 0.7 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.1 | 0.2 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 0.1 | 1.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 0.5 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.1 | 0.9 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 0.2 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.1 | 0.3 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.0 | 0.2 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 0.5 | GO:0033683 | nucleotide-excision repair, DNA incision(GO:0033683) |
| 0.0 | 0.3 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.0 | 0.7 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 0.2 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.0 | 0.4 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.0 | 0.3 | GO:0060613 | fat pad development(GO:0060613) |
| 0.0 | 0.3 | GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953) |
| 0.0 | 0.4 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.0 | 0.4 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.0 | 0.1 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) |
| 0.0 | 0.4 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.0 | 0.4 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.0 | 0.2 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.0 | 3.7 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 0.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.0 | 0.4 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.0 | 0.1 | GO:0016237 | lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157) |
| 0.0 | 0.7 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 1.6 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 0.3 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 0.1 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.0 | 0.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.2 | GO:0035547 | interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 0.1 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.0 | 0.2 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.0 | 0.1 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 0.0 | 0.1 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.0 | 0.3 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.0 | 0.1 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.0 | 0.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 0.1 | GO:0031282 | regulation of guanylate cyclase activity(GO:0031282) |
| 0.0 | 0.4 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 0.1 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.0 | 0.7 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.4 | GO:0031297 | replication fork processing(GO:0031297) |
| 0.0 | 0.0 | GO:0006566 | threonine metabolic process(GO:0006566) |
| 0.0 | 0.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 0.4 | GO:0045056 | transcytosis(GO:0045056) |
| 0.0 | 0.8 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.2 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
| 0.0 | 0.1 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.1 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.1 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 0.4 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.1 | GO:0046655 | dTMP biosynthetic process(GO:0006231) glycine biosynthetic process(GO:0006545) dTMP metabolic process(GO:0046073) folic acid metabolic process(GO:0046655) |
| 0.0 | 0.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.1 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.1 | GO:0006689 | ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313) |
| 0.0 | 0.9 | GO:0030819 | positive regulation of cAMP biosynthetic process(GO:0030819) |
| 0.0 | 0.1 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.0 | 0.2 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.0 | 0.3 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.8 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.0 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.0 | 0.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.1 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
| 0.0 | 0.1 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.0 | 0.2 | GO:0003094 | glomerular filtration(GO:0003094) |
| 0.0 | 0.0 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.0 | 0.0 | GO:0048539 | bone marrow development(GO:0048539) replicative senescence(GO:0090399) |
| 0.0 | 0.4 | GO:0016572 | histone phosphorylation(GO:0016572) |
| 0.0 | 0.2 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 0.9 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.9 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.3 | 1.3 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.2 | 0.7 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.2 | 0.8 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.2 | 0.6 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 0.1 | 0.4 | GO:0035101 | FACT complex(GO:0035101) |
| 0.1 | 0.4 | GO:0000802 | transverse filament(GO:0000802) |
| 0.1 | 1.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.4 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.8 | GO:1990393 | 3M complex(GO:1990393) |
| 0.1 | 0.4 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.1 | 1.0 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 0.9 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 0.5 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.1 | 0.7 | GO:0090576 | RNA polymerase III transcription factor complex(GO:0090576) |
| 0.1 | 0.9 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.7 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 0.3 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 0.4 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.1 | 1.0 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 0.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.8 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 0.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 0.4 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 0.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.3 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 0.6 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.2 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.5 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.6 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.7 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.4 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.5 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 0.4 | GO:0033202 | DNA helicase complex(GO:0033202) |
| 0.0 | 2.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.3 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.0 | 0.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 0.1 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
| 0.0 | 0.1 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.0 | 0.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.1 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.0 | 0.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 1.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.5 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 0.1 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.3 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.0 | 0.5 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.6 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.0 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.0 | 1.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.3 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.1 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.1 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 0.1 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.0 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.6 | 2.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.6 | 3.4 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.5 | 2.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.3 | 1.0 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.3 | 0.9 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.2 | 0.7 | GO:0001156 | TFIIIC-class transcription factor binding(GO:0001156) |
| 0.2 | 1.2 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.2 | 1.2 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.2 | 0.5 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.1 | 0.9 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 0.9 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.1 | 2.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.4 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924) |
| 0.1 | 0.7 | GO:0004661 | protein geranylgeranyltransferase activity(GO:0004661) |
| 0.1 | 0.6 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.1 | 1.0 | GO:0048495 | GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495) |
| 0.1 | 0.7 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 0.9 | GO:0043559 | insulin binding(GO:0043559) |
| 0.1 | 0.3 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.1 | 0.3 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.1 | 0.7 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.1 | 0.3 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 0.5 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.1 | 0.2 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.1 | 0.5 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.1 | 0.2 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.1 | 0.7 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.1 | 0.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.1 | 0.3 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
| 0.1 | 0.2 | GO:0003979 | UDP-glucose 6-dehydrogenase activity(GO:0003979) |
| 0.1 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 0.6 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.1 | 0.3 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.1 | 0.3 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.9 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 1.3 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 0.3 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 0.5 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.1 | 0.3 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.0 | 0.2 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.0 | 1.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.4 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.0 | 0.7 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.0 | 0.8 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 0.3 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.0 | 0.4 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.0 | 1.9 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.1 | GO:0070905 | serine binding(GO:0070905) |
| 0.0 | 0.1 | GO:0030249 | cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249) |
| 0.0 | 0.7 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.1 | GO:0019779 | Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779) |
| 0.0 | 0.8 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.0 | 0.7 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.1 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.0 | 0.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.4 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 0.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.2 | GO:0043176 | amine binding(GO:0043176) |
| 0.0 | 0.1 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) |
| 0.0 | 0.5 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.0 | GO:0034618 | arginine binding(GO:0034618) |
| 0.0 | 0.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.0 | 0.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.0 | 0.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.6 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.4 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.0 | 0.1 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.7 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.5 | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) |
| 0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.7 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.2 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 0.1 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.0 | 0.5 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 0.1 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.0 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.0 | 0.2 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.1 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 0.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.3 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.5 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 1.7 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.4 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.9 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.5 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.3 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.4 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.9 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.0 | 0.4 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.4 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.7 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 0.3 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 0.9 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.5 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.6 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 0.2 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.7 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.1 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.3 | PID_FOXO_PATHWAY | FoxO family signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.0 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 0.7 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 1.0 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 0.4 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.8 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 1.3 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.9 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.2 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 3.1 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.6 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
| 0.0 | 0.8 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.3 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.4 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 2.1 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.4 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.3 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 2.3 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 0.7 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 1.0 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.2 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.5 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.1 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.7 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 1.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.4 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.3 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.5 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.3 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.3 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 1.2 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 0.3 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
