Motif ID: Pitx3

Z-value: 0.631


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_62899118 3.372 ENSMUST00000174189.1
 Tet1
tet methylcytosine dioxygenase 1
chr1_-_186705980 2.321 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chrX_+_142226765 1.827 ENSMUST00000112916.2
 Nxt2
nuclear transport factor 2-like export factor 2
chr4_-_32923455 1.717 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr16_+_17276291 1.681 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chr9_+_118506226 1.589 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr10_+_128908907 1.324 ENSMUST00000105229.1
 Cd63
CD63 antigen
chr11_-_100770926 1.286 ENSMUST00000139341.1
ENSMUST00000017891.7
 Ghdc

GH3 domain containing

chr3_+_86070915 1.272 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr9_+_22454290 1.235 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr6_+_149582012 1.223 ENSMUST00000144085.2
 Gm21814
predicted gene, 21814
chr17_-_32800938 1.198 ENSMUST00000080905.6
 Zfp811
zinc finger protein 811
chr13_-_97747399 1.174 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_+_61956779 1.170 ENSMUST00000049836.7
 Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr5_+_3571664 1.155 ENSMUST00000008451.5
 1700109H08Rik
RIKEN cDNA 1700109H08 gene
chr13_-_77131276 1.140 ENSMUST00000159300.1
 Ankrd32
ankyrin repeat domain 32
chr10_+_81718919 1.137 ENSMUST00000085664.5
 Zfp433
RIKEN cDNA 1700123A16 gene
chr8_+_127447669 1.131 ENSMUST00000159511.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr9_-_62070606 1.111 ENSMUST00000034785.7
 Glce
glucuronyl C5-epimerase
chr13_-_23430826 1.095 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0001824 blastocyst development(GO:0001824)
0.7 3.4 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.5 3.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 2.3 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 2.1 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.3 1.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.3 1.6 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 1.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.3 1.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.3 1.3 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.1 1.3 GO:0097502 mannosylation(GO:0097502)
0.1 1.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 1.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.4 1.1 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) interleukin-1 alpha secretion(GO:0050703) regulation of bleb assembly(GO:1904170)
0.2 1.1 GO:0003383 apical constriction(GO:0003383)
0.3 1.0 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.2 1.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.0 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 1.0 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.3 0.9 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0005604 basement membrane(GO:0005604)
0.7 2.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.3 1.3 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 1.1 GO:0033269 internode region of axon(GO:0033269)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.0 GO:0070652 HAUS complex(GO:0070652)
0.1 1.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.9 GO:0031415 NatA complex(GO:0031415)
0.1 0.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.2 0.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.8 GO:1990393 3M complex(GO:1990393)
0.1 0.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 0.7 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 0.7 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.7 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.4 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.7 3.0 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.6 2.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.5 2.1 GO:0050436 microfibril binding(GO:0050436)
0.1 2.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.2 1.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.3 1.0 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 1.0 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.3 0.9 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.9 GO:0019841 retinol binding(GO:0019841)
0.1 0.9 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.9 GO:0043559 insulin binding(GO:0043559)
0.1 0.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.8 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.8 GO:0042287 MHC protein binding(GO:0042287)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 1.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.3 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 2.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.2 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.2 1.1 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.0 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.0 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 0.7 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events