Motif ID: Plag1

Z-value: 0.585


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_39384010.048.4e-01Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 2.958 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr6_-_48841373 1.174 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr1_-_172057573 1.095 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr11_+_77930800 1.053 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr6_-_48841098 1.003 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr17_+_72918298 0.973 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr17_-_87797994 0.930 ENSMUST00000055221.7
 Kcnk12
potassium channel, subfamily K, member 12
chr18_+_82914632 0.918 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr11_-_95587691 0.907 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr15_-_84856043 0.906 ENSMUST00000159939.1
 Phf21b
PHD finger protein 21B
chr9_+_54764748 0.870 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr6_-_48840988 0.842 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_+_120666388 0.815 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr2_+_20519776 0.810 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr4_-_63403330 0.802 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr12_-_45074112 0.778 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr11_+_101468164 0.755 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr11_-_69369377 0.743 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr15_-_32244632 0.716 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr8_-_87959560 0.673 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 2.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 1.4 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.2 1.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.3 1.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 1.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 0.9 GO:0016115 terpenoid catabolic process(GO:0016115)
0.2 0.9 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 0.9 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.1 0.9 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 0.8 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 0.8 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.2 0.8 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.8 GO:0001842 neural fold formation(GO:0001842)
0.1 0.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.8 GO:0050873 brown fat cell differentiation(GO:0050873)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0060170 ciliary membrane(GO:0060170)
0.3 1.4 GO:0060187 cell pole(GO:0060187)
0.1 1.3 GO:0000145 exocyst(GO:0000145)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.3 1.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 1.0 GO:0097440 apical dendrite(GO:0097440)
0.0 0.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.2 0.8 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.8 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.7 GO:0031105 septin complex(GO:0031105)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.2 0.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 0.6 GO:0090537 CERF complex(GO:0090537)
0.0 0.6 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 1.2 GO:0019841 retinol binding(GO:0019841)
0.1 1.0 GO:0008430 selenium binding(GO:0008430)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.9 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 0.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 0.8 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.2 0.8 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.2 0.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 0.7 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.6 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.6 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.6 GO:0048495 Roundabout binding(GO:0048495)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.8 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.3 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.0 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 1.0 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.7 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.1 0.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression