Motif ID: Plagl1

Z-value: 0.630


Transcription factors associated with Plagl1:

Gene SymbolEntrez IDGene Name
Plagl1 ENSMUSG00000019817.12 Plagl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.563.6e-04Click!


Activity profile for motif Plagl1.

activity profile for motif Plagl1


Sorted Z-values histogram for motif Plagl1

Sorted Z-values for motif Plagl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plagl1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_91807424 4.410 ENSMUST00000162300.1
Grip2
glutamate receptor interacting protein 2
chr6_-_91807318 3.931 ENSMUST00000159684.1
Grip2
glutamate receptor interacting protein 2
chr2_-_104257400 3.630 ENSMUST00000141159.1
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr17_+_46297406 3.449 ENSMUST00000061722.6
ENSMUST00000166280.1
Dlk2

delta-like 2 homolog (Drosophila)

chr4_+_152338619 2.909 ENSMUST00000030775.5
ENSMUST00000164662.1
Chd5

chromodomain helicase DNA binding protein 5

chr4_-_139092958 2.845 ENSMUST00000042844.6
Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr4_+_47288057 2.802 ENSMUST00000140413.1
ENSMUST00000107731.2
Col15a1

collagen, type XV, alpha 1

chr3_+_26331150 2.515 ENSMUST00000099182.2
A830092H15Rik
RIKEN cDNA A830092H15 gene
chr17_+_46297917 2.243 ENSMUST00000166617.1
ENSMUST00000170271.1
Dlk2

delta-like 2 homolog (Drosophila)

chr10_+_38965515 2.220 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr17_-_24644933 2.109 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr5_-_139130159 2.068 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_+_47288287 1.807 ENSMUST00000146967.1
Col15a1
collagen, type XV, alpha 1
chr9_+_75625707 1.792 ENSMUST00000034702.4
Lysmd2
LysM, putative peptidoglycan-binding, domain containing 2
chr3_-_108017806 1.776 ENSMUST00000126593.1
Gstm1
glutathione S-transferase, mu 1
chr11_-_120047144 1.747 ENSMUST00000103020.1
Aatk
apoptosis-associated tyrosine kinase
chr3_-_108017877 1.738 ENSMUST00000004140.4
Gstm1
glutathione S-transferase, mu 1
chr19_+_6497772 1.734 ENSMUST00000113458.1
ENSMUST00000113459.1
Nrxn2

neurexin II

chr7_-_99695809 1.600 ENSMUST00000107086.2
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr6_+_110645572 1.547 ENSMUST00000071076.6
ENSMUST00000172951.1
Grm7

glutamate receptor, metabotropic 7

chr6_+_4504814 1.537 ENSMUST00000141483.1
Col1a2
collagen, type I, alpha 2
chr11_+_98741871 1.524 ENSMUST00000103139.4
Thra
thyroid hormone receptor alpha
chr5_-_136567242 1.514 ENSMUST00000175975.2
ENSMUST00000176216.2
ENSMUST00000176745.1
Cux1


cut-like homeobox 1


chr13_+_5861489 1.406 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr11_+_98741805 1.371 ENSMUST00000064187.5
Thra
thyroid hormone receptor alpha
chr6_-_92481343 1.257 ENSMUST00000113445.1
Prickle2
prickle homolog 2 (Drosophila)
chr10_-_81482655 1.222 ENSMUST00000120508.1
ENSMUST00000118763.1
Celf5

CUGBP, Elav-like family member 5

chr6_-_128200598 1.177 ENSMUST00000071101.6
Gm10010
predicted gene 10010
chr6_-_128143525 1.100 ENSMUST00000032503.5
ENSMUST00000112173.1
Tspan9

tetraspanin 9

chr18_-_38601268 1.089 ENSMUST00000025295.6
Spry4
sprouty homolog 4 (Drosophila)
chr5_+_125475814 1.074 ENSMUST00000031445.3
Aacs
acetoacetyl-CoA synthetase
chr7_+_142533012 1.036 ENSMUST00000038675.6
Mrpl23
mitochondrial ribosomal protein L23
chr2_-_132145057 1.003 ENSMUST00000028815.8
Slc23a2
solute carrier family 23 (nucleobase transporters), member 2
chr15_+_75993756 0.974 ENSMUST00000089669.4
Mapk15
mitogen-activated protein kinase 15
chrX_-_73824938 0.899 ENSMUST00000114438.2
ENSMUST00000002080.5
Pdzd4

PDZ domain containing 4

chr4_+_106561027 0.883 ENSMUST00000047973.3
Dhcr24
24-dehydrocholesterol reductase
chr8_+_93810832 0.875 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr5_-_34187670 0.865 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr5_-_136883115 0.854 ENSMUST00000057497.6
ENSMUST00000111103.1
Col26a1

collagen, type XXVI, alpha 1

chr18_+_32377176 0.839 ENSMUST00000091967.5
ENSMUST00000025239.7
Bin1

bridging integrator 1

chr11_+_70018421 0.808 ENSMUST00000108588.1
Dlg4
discs, large homolog 4 (Drosophila)
chr10_-_81014902 0.785 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr4_+_129136948 0.779 ENSMUST00000102600.3
Fndc5
fibronectin type III domain containing 5
chr17_+_25016343 0.774 ENSMUST00000024983.5
Ift140
intraflagellar transport 140
chr1_-_120074023 0.756 ENSMUST00000056089.7
Tmem37
transmembrane protein 37
chr6_+_40325471 0.746 ENSMUST00000031977.8
Agk
acylglycerol kinase
chr4_+_101496648 0.729 ENSMUST00000106930.1
ENSMUST00000154120.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr11_+_32455362 0.709 ENSMUST00000051053.4
Ubtd2
ubiquitin domain containing 2
chr12_-_103443653 0.679 ENSMUST00000055071.8
Ifi27l2a
interferon, alpha-inducible protein 27 like 2A
chr1_-_88205674 0.663 ENSMUST00000119972.2
Dnajb3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr2_-_130642770 0.621 ENSMUST00000045761.6
Lzts3
leucine zipper, putative tumor suppressor family member 3
chr17_-_25868727 0.598 ENSMUST00000026828.5
Fam195a
family with sequence similarity 195, member A
chr16_+_91406235 0.564 ENSMUST00000023691.5
Il10rb
interleukin 10 receptor, beta
chr19_+_45047557 0.559 ENSMUST00000062213.5
ENSMUST00000111954.4
ENSMUST00000084493.6
Sfxn3


sideroflexin 3


chrX_-_75874536 0.545 ENSMUST00000033547.7
Pls3
plastin 3 (T-isoform)
chr19_+_4711153 0.526 ENSMUST00000008991.6
Sptbn2
spectrin beta, non-erythrocytic 2
chr19_+_5474681 0.507 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr2_-_152332639 0.501 ENSMUST00000028964.7
Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr5_+_24393640 0.495 ENSMUST00000138168.1
ENSMUST00000115077.1
Abcb8

ATP-binding cassette, sub-family B (MDR/TAP), member 8

chr1_-_179546261 0.484 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr5_-_92083455 0.476 ENSMUST00000169094.1
ENSMUST00000167918.1
G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr15_-_43869993 0.449 ENSMUST00000067469.4
Tmem74
transmembrane protein 74
chr12_+_100199435 0.447 ENSMUST00000110082.3
Calm1
calmodulin 1
chr8_-_25101985 0.432 ENSMUST00000128715.1
ENSMUST00000064883.6
Plekha2

pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2

chr16_+_32277449 0.431 ENSMUST00000155649.1
ENSMUST00000014218.8
ENSMUST00000171474.1
Rnf168


ring finger protein 168


chr1_+_74588347 0.411 ENSMUST00000113732.1
Bcs1l
BCS1-like (yeast)
chr5_-_92083667 0.380 ENSMUST00000113127.3
G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr19_-_4625612 0.377 ENSMUST00000025823.3
Rce1
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr2_-_152831112 0.373 ENSMUST00000128172.1
Bcl2l1
BCL2-like 1
chr12_+_110889231 0.373 ENSMUST00000169597.1
ENSMUST00000165978.1
Tecpr2

tectonin beta-propeller repeat containing 2

chr11_+_67966442 0.350 ENSMUST00000021286.4
ENSMUST00000108675.1
Stx8

syntaxin 8

chr1_+_74588289 0.342 ENSMUST00000113733.3
ENSMUST00000027358.4
Bcs1l

BCS1-like (yeast)

chr4_+_155249960 0.327 ENSMUST00000178473.1
ENSMUST00000105627.1
ENSMUST00000097747.2
2610002J02Rik


RIKEN cDNA 2610002J02 gene


chr2_+_25428699 0.320 ENSMUST00000102919.3
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr10_-_70599284 0.299 ENSMUST00000046513.3
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr9_+_46273064 0.277 ENSMUST00000156440.1
ENSMUST00000034583.6
ENSMUST00000114552.3
Zfp259


zinc finger protein 259


chr12_-_15816762 0.275 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chrX_+_20870166 0.272 ENSMUST00000115342.3
ENSMUST00000009530.4
Timp1

tissue inhibitor of metalloproteinase 1

chr17_+_29549783 0.262 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr12_-_69893162 0.261 ENSMUST00000049239.7
ENSMUST00000110570.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr8_-_13974715 0.256 ENSMUST00000119182.1
ENSMUST00000062613.4
Tdrp

testis development related protein

chr2_-_3419019 0.253 ENSMUST00000115084.1
ENSMUST00000115083.1
Meig1

meiosis expressed gene 1

chrX_+_99821021 0.252 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr6_+_124712279 0.233 ENSMUST00000004375.9
Phb2
prohibitin 2
chr8_-_40634750 0.223 ENSMUST00000173957.1
Mtmr7
myotubularin related protein 7
chr2_-_3419066 0.219 ENSMUST00000115082.3
Meig1
meiosis expressed gene 1
chr14_+_64588112 0.215 ENSMUST00000181808.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr10_+_80016901 0.201 ENSMUST00000105373.1
Hmha1
histocompatibility (minor) HA-1
chr5_-_24577467 0.183 ENSMUST00000030795.8
Abcf2
ATP-binding cassette, sub-family F (GCN20), member 2
chr2_-_65567465 0.175 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr8_-_40634776 0.169 ENSMUST00000048898.10
ENSMUST00000174205.1
Mtmr7

myotubularin related protein 7

chr5_-_143269958 0.154 ENSMUST00000161448.1
Zfp316
zinc finger protein 316
chr6_-_56704673 0.151 ENSMUST00000170382.2
Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_+_148160613 0.145 ENSMUST00000047951.8
Fbxo2
F-box protein 2
chr2_-_65567505 0.144 ENSMUST00000100069.2
Scn3a
sodium channel, voltage-gated, type III, alpha
chr6_+_83179568 0.144 ENSMUST00000113919.3
ENSMUST00000113918.1
ENSMUST00000141680.1
Dctn1


dynactin 1


chr7_+_45872772 0.130 ENSMUST00000002855.5
ENSMUST00000107719.1
Kdelr1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr6_-_48086530 0.101 ENSMUST00000073124.6
Zfp746
zinc finger protein 746
chrX_-_37085402 0.100 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr11_-_33843405 0.083 ENSMUST00000101368.2
Kcnip1
Kv channel-interacting protein 1
chr16_-_34262830 0.082 ENSMUST00000114947.1
Kalrn
kalirin, RhoGEF kinase
chr10_-_95415484 0.079 ENSMUST00000172070.1
ENSMUST00000150432.1
Socs2

suppressor of cytokine signaling 2

chr16_+_32099781 0.077 ENSMUST00000115168.2
Cep19
centrosomal protein 19
chr2_-_18998126 0.074 ENSMUST00000006912.5
Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr15_-_52478228 0.073 ENSMUST00000081993.1
Gm10020
predicted pseudogene 10020
chr1_+_134455524 0.072 ENSMUST00000112232.1
ENSMUST00000027725.4
ENSMUST00000116528.1
Klhl12


kelch-like 12


chr1_-_128103016 0.066 ENSMUST00000097597.2
Zranb3
zinc finger, RAN-binding domain containing 3
chr15_-_99251929 0.064 ENSMUST00000041190.9
ENSMUST00000163506.1
Mcrs1

microspherule protein 1

chr6_+_67266979 0.041 ENSMUST00000042990.4
Serbp1
serpine1 mRNA binding protein 1
chr11_+_87699897 0.041 ENSMUST00000040089.4
Rnf43
ring finger protein 43
chr12_-_56535047 0.039 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr16_-_19706365 0.036 ENSMUST00000081880.5
Lamp3
lysosomal-associated membrane protein 3
chr11_-_33843526 0.034 ENSMUST00000065970.5
ENSMUST00000109340.2
Kcnip1

Kv channel-interacting protein 1

chr9_+_108662098 0.026 ENSMUST00000035222.5
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr1_+_179546303 0.023 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr2_-_152830615 0.023 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
Bcl2l1



BCL2-like 1



chr16_-_56717182 0.022 ENSMUST00000141404.1
Tfg
Trk-fused gene
chr17_+_37193889 0.012 ENSMUST00000038844.6
Ubd
ubiquitin D
chr10_+_128377086 0.012 ENSMUST00000014642.3
Ankrd52
ankyrin repeat domain 52
chrX_+_163911401 0.005 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr17_+_29660710 0.003 ENSMUST00000130423.1
Cmtr1
cap methyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.8 8.3 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.7 2.8 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.4 1.3 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.4 2.9 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.3 1.0 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.3 1.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 3.5 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.2 2.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 1.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 1.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.4 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.1 5.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.7 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 1.5 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.4 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 1.7 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.1 0.8 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 0.9 GO:0031639 plasminogen activation(GO:0031639)
0.1 1.8 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 2.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.5 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.8 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 0.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.3 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.3 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045) negative regulation of trophoblast cell migration(GO:1901164)
0.0 0.2 GO:0060744 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 1.0 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 1.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.9 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.4 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.5 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.3 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.1 GO:0070542 response to fatty acid(GO:0070542)
0.0 0.7 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.1 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 0.0 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 1.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:0060125 negative regulation of growth hormone secretion(GO:0060125) maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.4 GO:0045022 early endosome to late endosome transport(GO:0045022)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0005584 collagen type I trimer(GO:0005584)
0.2 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.1 1.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.2 GO:0005605 basal lamina(GO:0005605)
0.1 0.5 GO:0008091 spectrin(GO:0008091)
0.1 0.8 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 5.5 GO:0005581 collagen trimer(GO:0005581)
0.1 8.3 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.7 GO:0032420 stereocilium(GO:0032420)
0.1 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.0 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.9 2.8 GO:0016015 morphogen activity(GO:0016015)
0.7 2.9 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.5 1.5 GO:0070905 serine binding(GO:0070905)
0.3 1.0 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.3 3.5 GO:0016151 nickel cation binding(GO:0016151)
0.3 1.1 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.2 0.7 GO:0001729 ceramide kinase activity(GO:0001729)
0.2 1.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.2 2.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.9 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.4 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 8.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 0.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 2.1 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.4 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 1.0 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.9 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 1.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.6 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 6.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.8 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 5.7 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.6 GO:0043621 protein self-association(GO:0043621)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 2.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 3.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 1.6 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 1.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 4.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.3 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 1.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.8 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis