Motif ID: Pou1f1

Z-value: 0.930


Transcription factors associated with Pou1f1:

Gene SymbolEntrez IDGene Name
Pou1f1 ENSMUSG00000004842.12 Pou1f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou1f1mm10_v2_chr16_+_65520503_65520548-0.182.9e-01Click!


Activity profile for motif Pou1f1.

activity profile for motif Pou1f1


Sorted Z-values histogram for motif Pou1f1

Sorted Z-values for motif Pou1f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou1f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 8.535 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr7_-_103853199 7.601 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr1_+_107511416 5.403 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511489 3.876 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_110099295 3.768 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr7_-_14562171 3.215 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr13_-_62607499 2.925 ENSMUST00000091563.4
 6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr1_+_109993982 2.819 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr4_+_134510999 2.800 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr5_-_53707532 2.688 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr11_-_11970540 2.642 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr17_+_21690766 2.491 ENSMUST00000097384.1
 Gm10509
predicted gene 10509
chr9_+_65890237 2.466 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr9_-_79977782 2.438 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr7_-_28008416 2.288 ENSMUST00000180024.1
 Zfp850
zinc finger protein 850
chr4_+_44300876 2.206 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr1_+_66364623 2.020 ENSMUST00000077355.5
ENSMUST00000114012.1
 Map2

microtubule-associated protein 2

chr2_+_164074122 2.015 ENSMUST00000018353.7
 Stk4
serine/threonine kinase 4
chr10_-_116972609 2.002 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chrX_+_151522352 1.981 ENSMUST00000148622.1
 Phf8
PHD finger protein 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.3 GO:0015671 oxygen transport(GO:0015671)
0.1 7.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 5.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 4.0 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.3 3.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 2.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.9 2.7 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.9 2.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 2.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 2.3 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.7 2.0 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.5 2.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 2.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.0 1.8 GO:0035329 hippo signaling(GO:0035329)
0.0 1.8 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.2 1.5 GO:0090166 Golgi disassembly(GO:0090166)
0.0 1.5 GO:0021591 ventricular system development(GO:0021591)
0.0 1.5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.2 GO:0005833 hemoglobin complex(GO:0005833)
0.3 2.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 2.9 GO:0000922 spindle pole(GO:0000922)
0.9 2.7 GO:0071914 prominosome(GO:0071914)
0.5 2.6 GO:0097149 centralspindlin complex(GO:0097149)
0.2 2.3 GO:0032009 early phagosome(GO:0032009)
0.0 1.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.2 1.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 1.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 1.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.3 GO:0043195 terminal bouton(GO:0043195)
0.1 1.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.2 GO:0000776 kinetochore(GO:0000776)
0.4 1.1 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.2 1.1 GO:0032133 chromosome passenger complex(GO:0032133)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 6.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 2.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 2.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.8 2.3 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.0 2.3 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.7 2.0 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.2 2.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 2.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 1.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.3 1.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.4 1.5 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.4 1.5 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.5 GO:0035173 histone kinase activity(GO:0035173)
0.2 1.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.7 PID_BARD1_PATHWAY BARD1 signaling events
0.2 1.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 0.8 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.5 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.5 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 4.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 3.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.9 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.5 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 1.3 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.1 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.1 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.1 1.0 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.