Motif ID: Pou2f1

Z-value: 0.629


Transcription factors associated with Pou2f1:

Gene SymbolEntrez IDGene Name
Pou2f1 ENSMUSG00000026565.12 Pou2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou2f1mm10_v2_chr1_-_166002613_166002678-0.343.9e-02Click!


Activity profile for motif Pou2f1.

activity profile for motif Pou2f1


Sorted Z-values histogram for motif Pou2f1

Sorted Z-values for motif Pou2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 5.720 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr10_-_102490418 2.446 ENSMUST00000020040.3
 Nts
neurotensin
chr12_+_38783455 1.651 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr4_+_13751297 1.565 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_127831817 1.410 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr5_-_5266038 1.260 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chrX_-_133688978 1.245 ENSMUST00000149154.1
ENSMUST00000167944.1
 Pcdh19

protocadherin 19

chr13_+_83573577 1.162 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr4_+_134510999 1.159 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr11_-_84525514 1.130 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr11_+_84525647 1.130 ENSMUST00000134800.1
 1500016L03Rik
RIKEN cDNA 1500016L03 gene
chr18_+_86711520 1.082 ENSMUST00000122464.1
 Cbln2
cerebellin 2 precursor protein
chr11_+_84525669 0.998 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr9_-_77347816 0.977 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr9_-_77347787 0.945 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr9_+_3000922 0.931 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr14_-_65833963 0.885 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chrX_-_23266751 0.877 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr8_+_76902277 0.871 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr15_+_94629148 0.831 ENSMUST00000080141.4
 Tmem117
transmembrane protein 117

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 2.4 GO:0008542 visual learning(GO:0008542)
0.2 1.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.6 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 1.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.5 1.4 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 1.3 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.4 1.2 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.4 1.1 GO:0072284 cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.1 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.9 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 0.9 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.9 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.8 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 0.7 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.2 0.7 GO:0046544 development of secondary male sexual characteristics(GO:0046544)
0.1 0.7 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0016605 PML body(GO:0016605)
0.0 2.1 GO:0043679 axon terminus(GO:0043679)
0.0 2.0 GO:0016363 nuclear matrix(GO:0016363)
0.4 1.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.3 1.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.9 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.1 0.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.7 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.6 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.6 GO:0005882 intermediate filament(GO:0005882)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.4 GO:0030289 protein phosphatase 4 complex(GO:0030289)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 2.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.1 1.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.7 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 0.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.5 GO:0031493 nucleosomal histone binding(GO:0031493) hemi-methylated DNA-binding(GO:0044729)
0.1 0.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.5 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 0.5 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.6 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 0.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation