Motif ID: Pou3f4

Z-value: 0.653


Transcription factors associated with Pou3f4:

Gene SymbolEntrez IDGene Name
Pou3f4 ENSMUSG00000056854.3 Pou3f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f4mm10_v2_chrX_+_110814390_110814413-0.391.7e-02Click!


Activity profile for motif Pou3f4.

activity profile for motif Pou3f4


Sorted Z-values histogram for motif Pou3f4

Sorted Z-values for motif Pou3f4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 147 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439719 4.991 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 4.764 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr1_+_159737510 4.440 ENSMUST00000111669.3
 Tnr
tenascin R
chr15_-_79285502 4.084 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr15_+_92161343 2.889 ENSMUST00000068378.5
 Cntn1
contactin 1
chr13_-_92030897 2.859 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr7_+_87803815 2.814 ENSMUST00000125009.1
ENSMUST00000155358.1
 Grm5

glutamate receptor, metabotropic 5

chr3_+_68869563 2.765 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr6_-_36811361 2.701 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr6_+_17463749 2.612 ENSMUST00000115443.1
 Met
met proto-oncogene
chr2_-_120245157 2.440 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr6_+_21215472 2.139 ENSMUST00000081542.5
 Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr14_-_30353468 2.085 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr6_+_17463826 2.080 ENSMUST00000140070.1
 Met
met proto-oncogene
chr3_+_26331150 2.067 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr3_+_67892189 2.013 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr8_-_84773381 1.955 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr9_-_40346290 1.866 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr18_+_36939178 1.831 ENSMUST00000115662.2
 Pcdha2
protocadherin alpha 2
chr2_-_5676046 1.822 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 9.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.7 4.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.1 4.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 4.1 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 2.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 2.9 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.9 2.8 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.9 2.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 2.4 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 2.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.5 2.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 2.1 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1 2.1 GO:0045475 locomotor rhythm(GO:0045475)
0.1 2.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 1.9 GO:0007416 synapse assembly(GO:0007416)
0.5 1.8 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.3 1.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 1.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.8 GO:0001553 luteinization(GO:0001553)
0.1 1.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0009925 basal plasma membrane(GO:0009925)
1.5 4.4 GO:0072534 perineuronal net(GO:0072534)
0.4 4.1 GO:0071439 clathrin complex(GO:0071439)
0.0 3.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.8 GO:0097449 astrocyte projection(GO:0097449)
0.0 2.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.2 1.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 0.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.6 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.5 GO:0042581 specific granule(GO:0042581)
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 4.4 GO:0046625 sphingolipid binding(GO:0046625)
0.7 2.8 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.9 2.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 2.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.4 2.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.3 2.1 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.3 1.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.5 1.8 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 1.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 1.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.0 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 0.9 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 0.9 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 3.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.0 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.0 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 0.9 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones