Motif ID: Pou4f1_Pou6f1

Z-value: 0.710

Transcription factors associated with Pou4f1_Pou6f1:

Gene SymbolEntrez IDGene Name
Pou4f1 ENSMUSG00000048349.8 Pou4f1
Pou6f1 ENSMUSG00000009739.10 Pou6f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou4f1mm10_v2_chr14_-_104467984_104468041-0.563.5e-04Click!
Pou6f1mm10_v2_chr15_-_100599983_1006000390.482.7e-03Click!


Activity profile for motif Pou4f1_Pou6f1.

activity profile for motif Pou4f1_Pou6f1


Sorted Z-values histogram for motif Pou4f1_Pou6f1

Sorted Z-values for motif Pou4f1_Pou6f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou4f1_Pou6f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439719 5.859 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 5.153 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr13_+_42681513 2.580 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr6_-_36811361 2.420 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr15_+_92161343 2.348 ENSMUST00000068378.5
 Cntn1
contactin 1
chr14_-_30353468 2.275 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr10_-_64090241 2.189 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr1_-_56978534 2.032 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr11_-_42182924 1.870 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr2_-_120245157 1.764 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr15_-_79285502 1.497 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr18_+_37504264 1.406 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr2_-_77519565 1.307 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr18_-_74961252 1.286 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr9_-_103222063 1.267 ENSMUST00000170904.1
 Trf
transferrin
chr3_+_68572245 1.252 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr16_+_91269759 1.230 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr2_-_93452679 1.222 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr1_+_12692430 1.205 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chr4_+_154964117 1.196 ENSMUST00000030931.4
ENSMUST00000070953.4
 Pank4

pantothenate kinase 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 11.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 3.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 2.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 2.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.8 2.4 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.6 2.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 2.3 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.2 1.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.8 GO:0009395 phospholipid catabolic process(GO:0009395)
0.4 1.7 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 1.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 1.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.5 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.1 1.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 1.3 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 1.3 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 1.3 GO:0001553 luteinization(GO:0001553)
0.3 1.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.2 GO:0016082 synaptic vesicle priming(GO:0016082)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 3.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 1.9 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 1.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 1.8 GO:0071439 clathrin complex(GO:0071439)
0.0 1.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.4 GO:0030017 sarcomere(GO:0030017)
0.1 1.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.0 GO:0030315 T-tubule(GO:0030315)
0.2 0.9 GO:0042627 chylomicron(GO:0042627)
0.0 0.9 GO:0014704 intercalated disc(GO:0014704)
0.2 0.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.6 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.8 2.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.3 2.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.3 1.9 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.7 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 1.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 1.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 1.3 GO:0002039 p53 binding(GO:0002039)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.4 1.1 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.3 1.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.3 1.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 1.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.0 GO:0016748 succinyltransferase activity(GO:0016748)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 2.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.1 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 1.0 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.9 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 0.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 0.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors