Motif ID: Pou6f2_Pou4f2

Z-value: 0.781

Transcription factors associated with Pou6f2_Pou4f2:

Gene SymbolEntrez IDGene Name
Pou4f2 ENSMUSG00000031688.3 Pou4f2
Pou6f2 ENSMUSG00000009734.11 Pou6f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou6f2mm10_v2_chr13_-_18382041_18382041-0.316.6e-02Click!
Pou4f2mm10_v2_chr8_-_78436640_78436649-0.307.4e-02Click!


Activity profile for motif Pou6f2_Pou4f2.

activity profile for motif Pou6f2_Pou4f2


Sorted Z-values histogram for motif Pou6f2_Pou4f2

Sorted Z-values for motif Pou6f2_Pou4f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

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Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_56296551 9.329 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr12_-_112511136 7.110 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr1_+_153665666 6.606 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_153665274 6.173 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_153665587 4.501 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr10_+_99263224 4.344 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr1_+_153665627 4.162 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr5_+_139543889 3.699 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_+_88724667 2.872 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr6_+_88724828 2.676 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr6_-_138422898 2.335 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chr6_-_138426735 2.314 ENSMUST00000162932.1
 Lmo3
LIM domain only 3
chr9_+_53771499 2.199 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr3_+_68572245 2.095 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr3_+_55782500 1.940 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr4_-_14621669 1.841 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621805 1.551 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr4_-_58499398 1.540 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr7_-_49636847 1.536 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr4_+_102589687 1.328 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 21.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
3.1 9.3 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.8 5.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 4.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.6 4.5 GO:0019532 oxalate transport(GO:0019532)
1.4 4.3 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.5 3.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 2.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 2.1 GO:0001553 luteinization(GO:0001553)
0.1 1.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 1.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.3 GO:0046549 retinal cone cell development(GO:0046549)
0.1 1.3 GO:0031424 keratinization(GO:0031424)
0.1 1.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 1.0 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.8 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.0 0.8 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.7 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 21.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 5.5 GO:0043196 varicosity(GO:0043196)
0.1 2.6 GO:0016235 aggresome(GO:0016235)
0.0 1.8 GO:0000792 heterochromatin(GO:0000792)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.9 GO:0030175 filopodium(GO:0030175)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 0.3 GO:0005883 neurofilament(GO:0005883)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 23.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 9.3 GO:0008009 chemokine activity(GO:0008009)
0.4 5.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 4.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 4.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.9 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 1.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 1.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 0.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.7 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.1 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.2 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 5.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 5.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 4.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors