Motif ID: Ppara

Z-value: 1.717


Transcription factors associated with Ppara:

Gene SymbolEntrez IDGene Name
Ppara ENSMUSG00000022383.7 Ppara



Activity profile for motif Ppara.

activity profile for motif Ppara


Sorted Z-values histogram for motif Ppara

Sorted Z-values for motif Ppara



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppara

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 14.092 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr15_-_66801577 9.884 ENSMUST00000168589.1
 Sla
src-like adaptor
chr6_-_138422898 9.569 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chr15_-_45114926 8.808 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chrX_-_72656135 7.817 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr8_+_118283719 7.652 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr11_+_67586675 7.500 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr5_-_44799643 7.360 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr13_-_9878998 7.268 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr11_+_67586520 7.044 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr10_-_64090265 6.893 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr7_-_74554474 6.632 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr2_-_13011747 6.171 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr3_-_36690118 5.915 ENSMUST00000029271.4
 Trpc3
transient receptor potential cation channel, subfamily C, member 3
chr11_+_7063423 5.873 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr12_+_109545390 5.800 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr10_-_64090241 5.724 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr7_-_25005895 5.712 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr11_-_33147400 5.700 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr4_+_13751297 5.584 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 317 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.6 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 12.3 GO:0030041 actin filament polymerization(GO:0030041)
0.8 11.2 GO:0015732 prostaglandin transport(GO:0015732)
2.0 10.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
1.0 9.3 GO:0071420 cellular response to histamine(GO:0071420)
0.9 9.2 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.2 9.2 GO:0006376 mRNA splice site selection(GO:0006376)
1.0 9.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 8.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 8.8 GO:0051260 protein homooligomerization(GO:0051260)
0.4 8.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
2.8 8.5 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.4 8.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.3 8.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 8.2 GO:0014003 oligodendrocyte development(GO:0014003)
1.5 7.7 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.1 7.6 GO:0050807 regulation of synapse organization(GO:0050807)
0.4 7.3 GO:0010669 epithelial structure maintenance(GO:0010669)
2.2 6.6 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 6.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.3 GO:0009986 cell surface(GO:0009986)
1.1 17.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 16.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 15.4 GO:0005884 actin filament(GO:0005884)
0.0 14.2 GO:0043025 neuronal cell body(GO:0043025)
0.1 12.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 11.8 GO:0031225 anchored component of membrane(GO:0031225)
0.5 9.3 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.1 8.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 7.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 7.5 GO:0005604 basement membrane(GO:0005604)
0.1 7.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 6.5 GO:0000118 histone deacetylase complex(GO:0000118)
1.3 6.3 GO:0044316 cone cell pedicle(GO:0044316)
0.7 6.2 GO:0097427 microtubule bundle(GO:0097427)
0.6 6.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 6.1 GO:0030137 COPI-coated vesicle(GO:0030137)
0.6 6.0 GO:0044326 dendritic spine neck(GO:0044326)
0.1 6.0 GO:0009925 basal plasma membrane(GO:0009925)
0.3 5.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 231 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.5 GO:0003779 actin binding(GO:0003779)
0.4 15.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 15.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.7 12.4 GO:0004890 GABA-A receptor activity(GO:0004890)
1.6 11.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
2.0 10.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 10.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 9.7 GO:0008022 protein C-terminus binding(GO:0008022)
1.5 8.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 8.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.4 8.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 7.9 GO:0030507 spectrin binding(GO:0030507)
1.5 7.7 GO:0055100 adiponectin binding(GO:0055100)
0.3 6.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 6.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 6.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.6 6.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 6.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
1.0 5.9 GO:0033142 progesterone receptor binding(GO:0033142)
0.5 5.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 7.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 7.4 PID_FGF_PATHWAY FGF signaling pathway
0.1 7.1 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 6.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 5.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 5.0 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 4.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 2.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 2.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 1.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 17.1 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 15.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.4 11.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.3 11.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.3 10.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.4 10.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 9.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 9.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.9 7.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 7.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 5.9 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 5.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 5.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 5.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.4 5.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 5.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 4.4 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.3 3.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 3.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events