Motif ID: Ppard

Z-value: 0.712


Transcription factors associated with Ppard:

Gene SymbolEntrez IDGene Name
Ppard ENSMUSG00000002250.9 Ppard

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ppardmm10_v2_chr17_+_28232723_282327890.732.6e-07Click!


Activity profile for motif Ppard.

activity profile for motif Ppard


Sorted Z-values histogram for motif Ppard

Sorted Z-values for motif Ppard



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppard

PNG image of the network

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Top targets:


Showing 1 to 20 of 71 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 6.512 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr5_-_115119277 4.831 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr15_+_25773985 3.846 ENSMUST00000125667.1
 Myo10
myosin X
chr4_+_59581563 3.645 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr4_+_59581645 3.559 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chrX_-_142306170 2.808 ENSMUST00000134825.2
 Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr1_-_120120138 2.011 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr4_+_118429701 1.865 ENSMUST00000067896.3
 Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr4_-_155043143 1.843 ENSMUST00000135665.2
 Plch2
phospholipase C, eta 2
chr9_-_51278540 1.781 ENSMUST00000114427.3
 Gm684
predicted gene 684
chr2_+_154436437 1.739 ENSMUST00000109725.1
ENSMUST00000099178.3
ENSMUST00000045270.8
ENSMUST00000109724.1
 Cbfa2t2



core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)



chr9_+_118506226 1.728 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr11_+_70657687 1.726 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr4_+_131873608 1.638 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr15_-_89425856 1.581 ENSMUST00000109313.2
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr10_-_13324160 1.495 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr4_+_98546919 1.454 ENSMUST00000030290.7
 Inadl
InaD-like (Drosophila)
chr3_-_79628660 1.443 ENSMUST00000120992.1
 Etfdh
electron transferring flavoprotein, dehydrogenase
chr4_+_98546710 1.404 ENSMUST00000102792.3
 Inadl
InaD-like (Drosophila)
chr11_-_70015346 1.396 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.5 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.5 4.8 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.2 4.0 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 3.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.4 2.8 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.2 2.5 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 2.4 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.4 2.0 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.2 1.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.8 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 1.8 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 1.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 1.7 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 1.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 1.4 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.3 1.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 1.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.9 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.1 0.9 GO:0090344 negative regulation of cell aging(GO:0090344)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 3.8 GO:0016459 myosin complex(GO:0016459)
0.0 3.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.7 2.6 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 2.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 1.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 0.9 GO:0031251 PAN complex(GO:0031251)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0016491 oxidoreductase activity(GO:0016491)
1.1 6.5 GO:0019841 retinol binding(GO:0019841)
0.3 4.8 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 3.8 GO:0030507 spectrin binding(GO:0030507)
0.4 2.8 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.5 2.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.7 2.0 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.5 2.0 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.2 1.9 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 1.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.5 1.4 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 1.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.2 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.2 0.9 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.7 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.7 GO:0070404 NADH binding(GO:0070404)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 3.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 2.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 2.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.2 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.1 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.1 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA Genes involved in Processing of Capped Intronless Pre-mRNA