Motif ID: Pparg_Rxrg

Z-value: 1.754

Transcription factors associated with Pparg_Rxrg:

Gene SymbolEntrez IDGene Name
Pparg ENSMUSG00000000440.6 Pparg
Rxrg ENSMUSG00000015843.4 Rxrg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrgmm10_v2_chr1_+_167598384_1675984110.163.4e-01Click!


Activity profile for motif Pparg_Rxrg.

activity profile for motif Pparg_Rxrg


Sorted Z-values histogram for motif Pparg_Rxrg

Sorted Z-values for motif Pparg_Rxrg



Network of associatons between targets according to the STRING database.



First level regulatory network of Pparg_Rxrg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_77894096 18.766 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr5_-_115119277 14.095 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr17_+_35049966 12.314 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr11_+_80300866 10.915 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr9_+_118506226 10.091 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr4_+_126556935 9.657 ENSMUST00000048391.8
 Clspn
claspin
chr13_-_24761861 8.869 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr11_+_61485431 8.624 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr2_-_79456750 8.513 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr4_-_126736236 8.347 ENSMUST00000048194.7
 Tfap2e
transcription factor AP-2, epsilon
chr1_-_138847579 7.852 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr4_+_9269285 7.559 ENSMUST00000038841.7
 Clvs1
clavesin 1
chr3_+_87948666 7.346 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr11_-_100354040 7.235 ENSMUST00000173630.1
 Hap1
huntingtin-associated protein 1
chr4_+_126556994 7.127 ENSMUST00000147675.1
 Clspn
claspin
chr14_+_54476100 6.662 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr14_-_67715585 5.796 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr6_+_83137089 5.697 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr2_-_26516620 5.455 ENSMUST00000132820.1
 Notch1
notch 1
chr11_-_100759942 5.297 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 344 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 26.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
6.3 18.8 GO:0006553 lysine metabolic process(GO:0006553)
2.0 18.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.0 17.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 13.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 11.5 GO:0015914 phospholipid transport(GO:0015914)
2.8 11.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
1.1 10.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
1.5 10.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.2 10.4 GO:0071493 cellular response to UV-B(GO:0071493)
0.2 9.8 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
2.1 8.5 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 8.5 GO:0008156 negative regulation of DNA replication(GO:0008156)
1.6 7.9 GO:0035262 gonad morphogenesis(GO:0035262)
1.0 7.8 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 7.4 GO:0007160 cell-matrix adhesion(GO:0007160)
0.7 7.3 GO:0042573 retinoic acid metabolic process(GO:0042573)
1.4 7.2 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.2 7.1 GO:2001222 regulation of neuron migration(GO:2001222)
1.7 7.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 29.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 24.2 GO:0005694 chromosome(GO:0005694)
0.1 12.8 GO:0005814 centriole(GO:0005814)
0.8 10.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
2.1 10.3 GO:0097149 centralspindlin complex(GO:0097149)
0.0 10.2 GO:0016607 nuclear speck(GO:0016607)
2.9 8.6 GO:0071953 elastic fiber(GO:0071953)
0.1 8.5 GO:0000922 spindle pole(GO:0000922)
2.0 8.0 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.2 7.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 6.3 GO:0001650 fibrillar center(GO:0001650)
0.1 6.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
1.1 5.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.6 5.4 GO:0030478 actin cap(GO:0030478)
0.1 5.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 4.7 GO:0000145 exocyst(GO:0000145)
0.0 4.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 4.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
1.3 4.0 GO:0071149 TEAD-2-YAP complex(GO:0071149)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 239 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 18.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.8 16.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 15.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 14.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
1.0 13.6 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.6 10.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
1.1 10.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 9.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 9.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.4 8.5 GO:0035497 cAMP response element binding(GO:0035497)
0.2 8.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 8.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 7.8 GO:0005254 chloride channel activity(GO:0005254)
0.3 7.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 7.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 7.1 GO:0008430 selenium binding(GO:0008430)
0.2 7.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 7.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 7.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 6.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 37.2 PID_PLK1_PATHWAY PLK1 signaling events
0.4 18.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 16.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 10.1 ST_STAT3_PATHWAY STAT3 Pathway
0.1 7.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 6.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.2 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 4.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.0 PID_BARD1_PATHWAY BARD1 signaling events
0.1 4.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 3.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 3.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 3.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 26.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 13.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 10.1 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.6 8.9 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 7.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 7.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 7.6 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.3 7.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 7.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 6.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 5.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 5.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 5.0 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 4.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 4.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 4.6 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.2 4.3 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 4.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 4.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 3.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors