Motif ID: Prdm1

Z-value: 0.942


Transcription factors associated with Prdm1:

Gene SymbolEntrez IDGene Name
Prdm1 ENSMUSG00000038151.6 Prdm1



Activity profile for motif Prdm1.

activity profile for motif Prdm1


Sorted Z-values histogram for motif Prdm1

Sorted Z-values for motif Prdm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prdm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 5.482 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr4_-_154636831 5.443 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr8_-_84800344 5.382 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr4_+_48049080 4.691 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr3_-_107760221 4.628 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr5_+_3343893 4.237 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr1_-_156674290 4.125 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr1_-_56978534 3.695 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr2_+_116067213 3.675 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr16_+_43363855 3.558 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr15_+_32920723 3.477 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr13_-_23430826 3.428 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr11_-_77894096 3.307 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr9_-_107668967 3.114 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr6_+_117168535 3.048 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
 Cxcl12


chemokine (C-X-C motif) ligand 12


chr16_+_43364145 3.035 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr3_-_101604580 2.603 ENSMUST00000036493.6
 Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr6_-_39118211 2.446 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_-_96591555 2.368 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr12_+_83987854 2.329 ENSMUST00000021649.7
 Acot2
acyl-CoA thioesterase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 6.7 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 6.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.2 6.5 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
1.6 4.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.6 4.2 GO:0044838 cell quiescence(GO:0044838)
0.2 3.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.2 3.6 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
1.1 3.4 GO:0042196 dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
0.2 3.4 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.1 3.3 GO:0006553 lysine metabolic process(GO:0006553)
0.6 3.1 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.8 3.0 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 3.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.7 2.6 GO:1903416 response to glycoside(GO:1903416)
0.0 2.6 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.3 2.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.7 2.0 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.2 1.8 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 1.8 GO:0008654 phospholipid biosynthetic process(GO:0008654)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005925 focal adhesion(GO:0005925)
0.1 5.2 GO:0016235 aggresome(GO:0016235)
0.1 5.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.0 GO:0009897 external side of plasma membrane(GO:0009897)
1.5 4.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 3.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 2.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 1.3 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.2 0.9 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.1 0.7 GO:0030870 Mre11 complex(GO:0030870)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 7.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 4.5 GO:0001223 transcription coactivator binding(GO:0001223)
1.4 4.2 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 4.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
1.2 3.6 GO:0004454 ketohexokinase activity(GO:0004454)
0.0 3.5 GO:0005125 cytokine activity(GO:0005125)
1.1 3.4 GO:0019120 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.1 3.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 3.4 GO:0019843 rRNA binding(GO:0019843)
0.8 3.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.0 3.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.3 3.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 2.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 2.6 GO:1990239 steroid hormone binding(GO:1990239)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.5 1.9 GO:0019863 IgE binding(GO:0019863)
0.2 1.8 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.5 4.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.2 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_ATM_PATHWAY ATM pathway
0.0 0.6 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 4.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 3.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 3.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 2.7 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 2.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.4 REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 1.9 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 1.7 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.7 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 1.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 1.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.4 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 1.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 1.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.0 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC