Motif ID: Prop1

Z-value: 0.892


Transcription factors associated with Prop1:

Gene SymbolEntrez IDGene Name
Prop1 ENSMUSG00000044542.3 Prop1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prop1mm10_v2_chr11_-_50953745_509537680.019.8e-01Click!


Activity profile for motif Prop1.

activity profile for motif Prop1


Sorted Z-values histogram for motif Prop1

Sorted Z-values for motif Prop1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prop1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_64090241 6.502 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_45470201 5.999 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr18_-_66860458 5.921 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr13_+_94875600 5.544 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr10_-_64090265 5.087 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_-_13972617 5.003 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr9_+_118478182 4.948 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 4.712 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr14_+_75455957 3.991 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr1_+_6734827 3.679 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr16_-_16829276 3.518 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr1_+_107511416 3.415 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr2_+_61804453 3.301 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr4_-_110292719 3.210 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_-_40893222 3.114 ENSMUST00000096000.3
 Sh2d4b
SH2 domain containing 4B
chr3_+_146121655 3.072 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr15_-_56694525 2.898 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr17_+_27556613 2.774 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr17_+_27556641 2.691 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr17_+_27556668 2.687 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 11.6 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
3.2 9.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 7.2 GO:0006284 base-excision repair(GO:0006284)
0.7 6.0 GO:0010587 miRNA catabolic process(GO:0010587)
1.2 5.9 GO:0002024 diet induced thermogenesis(GO:0002024)
0.4 5.5 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.6 4.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.8 4.0 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.3 3.7 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.7 3.3 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.1 3.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 3.0 GO:0043488 regulation of mRNA stability(GO:0043488)
0.7 2.9 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 2.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.5 2.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.2 2.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 2.4 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.5 2.3 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 2.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.5 2.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.5 GO:0045211 postsynaptic membrane(GO:0045211)
1.2 8.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.5 3.2 GO:0031262 Ndc80 complex(GO:0031262)
0.2 3.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 2.2 GO:0044305 calyx of Held(GO:0044305)
0.2 2.1 GO:0070852 cell body fiber(GO:0070852)
0.5 2.0 GO:0008623 CHRAC(GO:0008623)
0.4 1.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.6 GO:0045179 apical cortex(GO:0045179)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.5 1.4 GO:0035061 interchromatin granule(GO:0035061)
0.2 1.1 GO:0032437 cuticular plate(GO:0032437)
0.0 1.1 GO:0001891 phagocytic cup(GO:0001891)
0.3 1.0 GO:1990423 RZZ complex(GO:1990423)
0.1 1.0 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 1.0 GO:0005721 pericentric heterochromatin(GO:0005721)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 10.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.8 8.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
2.0 5.9 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 5.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.2 4.6 GO:0008142 oxysterol binding(GO:0008142)
0.0 3.6 GO:0005496 steroid binding(GO:0005496)
0.0 3.4 GO:0001047 core promoter binding(GO:0001047)
0.0 3.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 3.2 GO:0017091 AU-rich element binding(GO:0017091)
1.0 2.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.8 2.5 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.7 2.2 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.7 2.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.3 2.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 1.9 GO:0000150 recombinase activity(GO:0000150)
0.2 1.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 1.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 8.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 6.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 4.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 3.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 5.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.2 2.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 2.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.7 2.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 2.1 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.2 1.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.6 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT Genes involved in Aquaporin-mediated transport
0.1 1.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 1.1 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins