Motif ID: Prox1

Z-value: 0.426


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.632.7e-05Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 79 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_68954351 1.842 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr1_-_169747634 1.309 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr10_-_81025521 1.235 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_+_130913120 1.174 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr6_-_131388417 1.149 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr15_-_80014808 1.057 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr4_+_130913264 0.963 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr10_-_81025406 0.889 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr7_-_127449109 0.872 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689
chr18_-_67245818 0.865 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr7_-_127448993 0.853 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr12_-_83487708 0.823 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr5_-_37824580 0.793 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chrX_-_43274786 0.718 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr2_+_136891501 0.702 ENSMUST00000141463.1
 Slx4ip
SLX4 interacting protein
chr11_+_19924403 0.669 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr4_+_42950369 0.636 ENSMUST00000084662.5
 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_-_168734236 0.633 ENSMUST00000109175.2
 Atp9a
ATPase, class II, type 9A
chr11_+_19924354 0.552 ENSMUST00000093299.6
 Spred2
sprouty-related, EVH1 domain containing 2
chr2_-_92459709 0.535 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 1.8 GO:0042711 maternal behavior(GO:0042711)
0.0 1.3 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 1.2 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.1 1.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.4 1.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.4 1.1 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0 1.0 GO:0031648 protein destabilization(GO:0031648)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.3 0.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.8 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 0.5 GO:0019389 urate transport(GO:0015747) glucuronoside metabolic process(GO:0019389) negative regulation of intestinal absorption(GO:1904479)
0.1 0.5 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.3 GO:0090292 nuclear matrix organization(GO:0043578) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) nuclear matrix anchoring at nuclear membrane(GO:0090292) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.3 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.3 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0005921 gap junction(GO:0005921)
0.2 1.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.8 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.8 GO:0071565 nBAF complex(GO:0071565)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 1.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.4 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.3 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.9 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.8 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.5 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression