Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.690

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.482.9e-03Click!
Prrx1mm10_v2_chr1_-_163313661_1633137100.473.6e-03Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_79386943 5.077 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr14_+_80000292 2.716 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr14_-_101609033 2.379 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chrM_+_11734 2.341 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr3_+_86070915 2.274 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr9_+_118478344 2.018 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_-_160619971 1.959 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr15_-_8710734 1.932 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_118478182 1.924 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_116067213 1.833 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr5_-_62766153 1.774 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_49757257 1.648 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr4_-_87806296 1.395 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr5_-_124095749 1.344 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr1_+_58210397 1.319 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr15_-_8710409 1.273 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_32923455 1.221 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr15_-_37459327 1.206 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr4_-_87806276 1.180 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_163725123 1.167 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0007601 visual perception(GO:0007601)
1.3 3.9 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 3.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 3.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 3.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.8 3.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 2.4 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 2.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 1.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 1.7 GO:0002076 osteoblast development(GO:0002076)
0.1 1.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.6 GO:0007416 synapse assembly(GO:0007416)
0.5 1.5 GO:0006566 threonine metabolic process(GO:0006566)
0.0 1.4 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 1.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.4 1.3 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 1.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 1.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0070469 respiratory chain(GO:0070469)
0.0 3.3 GO:0044297 cell body(GO:0044297)
0.2 2.7 GO:0042581 specific granule(GO:0042581)
0.0 2.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.3 1.0 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.1 0.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.1 GO:0019841 retinol binding(GO:0019841)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 3.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 3.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 3.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 2.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 1.3 GO:0030151 molybdenum ion binding(GO:0030151)
0.3 1.3 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.4 1.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.4 1.1 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.9 GO:0042605 peptide antigen binding(GO:0042605)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 4.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 1.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 1.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 0.7 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins