Motif ID: Rad21_Smc3

Z-value: 0.672

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rad21mm10_v2_chr15_-_51991679_519917600.134.5e-01Click!
Smc3mm10_v2_chr19_+_53600377_536004350.067.2e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_110168204 3.538 ENSMUST00000003754.6
 Calb2
calbindin 2
chr11_-_114795888 2.808 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr2_-_117342709 2.388 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr7_+_35119285 2.316 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr9_-_42944479 2.005 ENSMUST00000114865.1
 Grik4
glutamate receptor, ionotropic, kainate 4
chr8_+_119446719 1.978 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr18_-_34007206 1.897 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chr2_+_172550991 1.854 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr2_+_157914618 1.824 ENSMUST00000109523.1
 Vstm2l
V-set and transmembrane domain containing 2-like
chr8_+_87473116 1.787 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr11_-_59964936 1.751 ENSMUST00000062405.7
 Rasd1
RAS, dexamethasone-induced 1
chr5_+_17574268 1.749 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_+_91517615 1.603 ENSMUST00000040576.9
 Parm1
prostate androgen-regulated mucin-like protein 1
chr8_+_87472805 1.530 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr17_-_33890584 1.521 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr17_+_26917091 1.474 ENSMUST00000078961.4
 Kifc5b
kinesin family member C5B
chr7_+_16891755 1.444 ENSMUST00000078182.4
 Gng8
guanine nucleotide binding protein (G protein), gamma 8
chr3_-_121171678 1.359 ENSMUST00000170781.1
ENSMUST00000039761.5
ENSMUST00000106467.1
ENSMUST00000106466.3
ENSMUST00000164925.2
 Rwdd3




RWD domain containing 3




chr7_-_19698206 1.358 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr7_-_19698383 1.344 ENSMUST00000173739.1
 Apoe
apolipoprotein E

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.9 2.8 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.9 2.7 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.9 2.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 2.4 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.8 2.3 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.0 2.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.7 2.0 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.7 2.0 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.1 1.8 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.3 1.7 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 1.6 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.5 1.4 GO:1902071 positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.3 1.4 GO:0019236 response to pheromone(GO:0019236)
0.1 1.3 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 1.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.4 1.2 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.2 1.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 1.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 1.2 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0005921 gap junction(GO:0005921)
0.1 2.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.9 2.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.9 2.6 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.3 2.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.9 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 1.4 GO:0045179 apical cortex(GO:0045179)
0.0 1.4 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.1 1.2 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 1.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.1 GO:0045178 basal part of cell(GO:0045178)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.1 0.9 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.9 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.9 2.7 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 2.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 2.4 GO:0030332 cyclin binding(GO:0030332)
0.1 2.3 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.7 2.0 GO:0004454 ketohexokinase activity(GO:0004454)
0.5 2.0 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.1 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.4 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 1.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 1.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 1.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.1 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.2 1.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 1.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.2 1.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 0.7 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.5 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.4 REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 2.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 2.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 0.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.8 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.8 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.7 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein