Motif ID: Rbpj

Z-value: 0.868


Transcription factors associated with Rbpj:

Gene SymbolEntrez IDGene Name
Rbpj ENSMUSG00000039191.6 Rbpj

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rbpjmm10_v2_chr5_+_53590453_535905740.554.5e-04Click!


Activity profile for motif Rbpj.

activity profile for motif Rbpj


Sorted Z-values histogram for motif Rbpj

Sorted Z-values for motif Rbpj



Network of associatons between targets according to the STRING database.



First level regulatory network of Rbpj

PNG image of the network

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Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_11007635 4.079 ENSMUST00000054776.3
 Plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr15_-_86033777 3.639 ENSMUST00000016172.7
 Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr2_+_105668888 3.280 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr2_+_105668935 3.252 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr4_+_107830958 2.736 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr9_+_123478693 2.643 ENSMUST00000026269.2
 Limd1
LIM domains containing 1
chrX_+_139684980 2.472 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr11_+_101627942 2.287 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr2_+_133552159 2.044 ENSMUST00000028836.6
 Bmp2
bone morphogenetic protein 2
chr7_+_126781483 1.992 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr11_-_102579461 1.963 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr4_+_8690399 1.919 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr2_+_59612034 1.904 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr7_-_44670820 1.658 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr7_+_45216671 1.608 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_+_44748584 1.601 ENSMUST00000171821.1
 Vrk3
vaccinia related kinase 3
chr3_-_89270489 1.494 ENSMUST00000107460.1
ENSMUST00000029565.4
ENSMUST00000130230.1
 Slc50a1


solute carrier family 50 (sugar transporter), member 1


chr7_+_44748640 1.483 ENSMUST00000165957.1
ENSMUST00000144515.2
 Vrk3

vaccinia related kinase 3

chr10_-_30842765 1.466 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr11_-_62457772 1.336 ENSMUST00000127471.2
 Ncor1
nuclear receptor co-repressor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.5 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.2 4.4 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
1.2 3.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 2.7 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.4 2.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 2.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.6 2.3 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.7 2.0 GO:0060129 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.2 2.0 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.6 1.9 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 1.9 GO:0097062 dendritic spine maintenance(GO:0097062)
0.2 1.7 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.1 1.7 GO:0071625 vocalization behavior(GO:0071625)
0.1 1.6 GO:0048368 lateral mesoderm development(GO:0048368)
0.7 1.5 GO:0003195 tricuspid valve formation(GO:0003195)
0.1 1.5 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.2 GO:0045056 transcytosis(GO:0045056)
0.2 0.9 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0005667 transcription factor complex(GO:0005667)
0.2 3.8 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.7 GO:0005901 caveola(GO:0005901)
0.2 2.6 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.3 1.7 GO:0097513 myosin II filament(GO:0097513)
0.5 1.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)
0.2 0.9 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 0.9 GO:0097433 dense body(GO:0097433)
0.1 0.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 0.8 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.2 0.7 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 4.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 3.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.7 2.7 GO:0038025 reelin receptor activity(GO:0038025)
0.3 2.3 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 2.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 2.0 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 2.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.5 1.5 GO:0035939 microsatellite binding(GO:0035939)
0.0 1.5 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.3 GO:0004697 protein kinase C activity(GO:0004697)
0.4 1.2 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 0.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.9 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.9 GO:0042809 vitamin D receptor binding(GO:0042809)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 PID_CDC42_PATHWAY CDC42 signaling events
0.1 4.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.1 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.4 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 2.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 2.7 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 2.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 1.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.1 0.9 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 0.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs