Motif ID: Rest

Z-value: 2.354


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_772662320.511.3e-03Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Showing 1 to 20 of 80 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_42255704 30.695 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr6_-_121473630 24.080 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr5_-_121009510 15.957 ENSMUST00000079204.5
 Rph3a
rabphilin 3A
chr2_-_25319095 13.446 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr2_-_27142429 12.452 ENSMUST00000151224.2
 Fam163b
family with sequence similarity 163, member B
chr17_+_28575718 11.817 ENSMUST00000080780.6
 Lhfpl5
lipoma HMGIC fusion partner-like 5
chr16_-_23890805 11.782 ENSMUST00000004480.3
 Sst
somatostatin
chr7_-_27396542 11.494 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr18_-_31447383 11.284 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr1_+_34579693 11.256 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr7_+_122671378 11.133 ENSMUST00000182563.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr12_-_112511136 11.046 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr2_-_25319187 10.851 ENSMUST00000114312.1
 Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr7_+_122671401 10.300 ENSMUST00000182095.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr19_+_22139028 9.915 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
 Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr11_-_35798884 9.469 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr9_+_40269430 9.302 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269273 9.097 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr12_-_84698769 8.522 ENSMUST00000095550.2
 Syndig1l
synapse differentiation inducing 1 like
chr9_+_40269202 8.398 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 30.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
3.0 26.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
8.1 24.3 GO:1900673 olefin metabolic process(GO:1900673)
0.9 24.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.8 21.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.5 16.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.0 15.6 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
1.9 11.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.4 11.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
1.9 9.5 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.6 8.4 GO:0043084 penile erection(GO:0043084)
0.4 8.1 GO:0071625 vocalization behavior(GO:0071625)
0.4 7.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 7.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.5 7.5 GO:0007220 Notch receptor processing(GO:0007220)
0.0 7.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.5 6.6 GO:0097091 synaptic vesicle clustering(GO:0097091)
2.0 6.1 GO:0006566 threonine metabolic process(GO:0006566)
1.5 6.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.3 6.1 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 30.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
1.8 26.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
6.1 24.3 GO:0044307 dendritic branch(GO:0044307)
0.5 21.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 19.7 GO:0019898 extrinsic component of membrane(GO:0019898)
0.6 18.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 18.2 GO:0043025 neuronal cell body(GO:0043025)
0.0 14.1 GO:0005794 Golgi apparatus(GO:0005794)
1.1 11.8 GO:0032426 stereocilium tip(GO:0032426)
1.9 11.5 GO:0008091 spectrin(GO:0008091)
0.8 11.3 GO:0097449 astrocyte projection(GO:0097449)
1.4 9.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 8.4 GO:0030667 secretory granule membrane(GO:0030667)
0.1 7.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 6.6 GO:0000795 synaptonemal complex(GO:0000795)
0.7 6.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.5 6.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 5.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.4 5.4 GO:0044294 dendritic growth cone(GO:0044294)
1.2 4.9 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 30.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
3.8 26.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
4.0 24.3 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.8 24.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 21.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.6 16.0 GO:0042301 phosphate ion binding(GO:0042301)
0.3 14.5 GO:0005179 hormone activity(GO:0005179)
0.1 14.5 GO:0051219 phosphoprotein binding(GO:0051219)
2.8 11.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 11.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 9.9 GO:0005261 cation channel activity(GO:0005261)
0.4 9.6 GO:0030506 ankyrin binding(GO:0030506)
0.6 9.5 GO:0008649 rRNA methyltransferase activity(GO:0008649)
2.0 7.9 GO:0004966 galanin receptor activity(GO:0004966)
0.4 7.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 7.5 GO:0005112 Notch binding(GO:0005112)
0.1 7.3 GO:0015485 cholesterol binding(GO:0015485)
0.4 7.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
2.0 6.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.5 6.1 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 7.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 5.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 3.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 43.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.0 24.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.6 21.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 10.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 7.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 7.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 6.6 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 5.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 3.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 3.3 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.5 3.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 2.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 2.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis