Motif ID: Rfx2_Rfx7

Z-value: 1.076

Transcription factors associated with Rfx2_Rfx7:

Gene SymbolEntrez IDGene Name
Rfx2 ENSMUSG00000024206.8 Rfx2
Rfx7 ENSMUSG00000037674.9 Rfx7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx2mm10_v2_chr17_-_56830916_568310080.048.0e-01Click!
Rfx7mm10_v2_chr9_+_72532214_725322710.019.6e-01Click!


Activity profile for motif Rfx2_Rfx7.

activity profile for motif Rfx2_Rfx7


Sorted Z-values histogram for motif Rfx2_Rfx7

Sorted Z-values for motif Rfx2_Rfx7



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx2_Rfx7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_128953303 5.446 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr8_+_94772009 4.088 ENSMUST00000034230.5
 Cx3cl1
chemokine (C-X3-C motif) ligand 1
chr12_-_40038025 3.825 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A
chr4_+_129960760 3.812 ENSMUST00000139884.1
 1700003M07Rik
RIKEN cDNA 1700003M07 gene
chrX_+_52791179 3.688 ENSMUST00000101588.1
 Ccdc160
coiled-coil domain containing 160
chr8_+_39005880 3.393 ENSMUST00000169034.1
 Tusc3
tumor suppressor candidate 3
chr5_+_27261916 3.296 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr7_-_31051431 3.201 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr8_+_39005827 3.158 ENSMUST00000167992.1
 Tusc3
tumor suppressor candidate 3
chr2_-_28466266 2.960 ENSMUST00000127683.1
ENSMUST00000086370.4
 1700007K13Rik

RIKEN cDNA 1700007K13 gene

chr18_+_75820174 2.881 ENSMUST00000058997.7
 Zbtb7c
zinc finger and BTB domain containing 7C
chr7_+_16959714 2.565 ENSMUST00000038163.6
 Pnmal1
PNMA-like 1
chr14_-_37098211 2.459 ENSMUST00000022337.9
 Cdhr1
cadherin-related family member 1
chr2_-_21205342 2.412 ENSMUST00000027992.2
 Enkur
enkurin, TRPC channel interacting protein
chr13_+_83504032 2.287 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr5_+_30281377 2.281 ENSMUST00000101448.3
 Drc1
dynein regulatory complex subunit 1
chr13_+_112993868 2.220 ENSMUST00000092089.4
 Mcidas
multiciliate differentiation and DNA synthesis associated cell cycle protein
chr7_+_4922251 2.152 ENSMUST00000047309.5
 Nat14
N-acetyltransferase 14
chr11_-_77725281 2.087 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr11_+_100545607 2.004 ENSMUST00000092684.5
ENSMUST00000006976.7
 Ttc25

tetratricopeptide repeat domain 25


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.6 GO:0015693 magnesium ion transport(GO:0015693)
0.1 5.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 4.4 GO:0008063 Toll signaling pathway(GO:0008063)
1.0 4.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 4.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 3.3 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.1 3.2 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.3 2.7 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 2.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.4 GO:0046847 filopodium assembly(GO:0046847)
0.8 2.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.4 2.3 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 2.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 2.1 GO:0015871 choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536)
0.2 1.9 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.4 1.6 GO:0046898 response to cycloheximide(GO:0046898)
0.3 1.6 GO:1904717 positive regulation of synapse structural plasticity(GO:0051835) regulation of AMPA glutamate receptor clustering(GO:1904717)
0.1 1.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 1.6 GO:0034620 cellular response to unfolded protein(GO:0034620)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 4.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 3.3 GO:0060170 ciliary membrane(GO:0060170)
0.0 3.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.1 GO:0045202 synapse(GO:0045202)
0.2 2.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.8 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.8 GO:0030017 sarcomere(GO:0030017)
0.1 1.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 1.3 GO:1990769 proximal neuron projection(GO:1990769)
0.0 1.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.2 GO:0000235 astral microtubule(GO:0000235)
0.1 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 1.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0097546 ciliary base(GO:0097546)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.4 4.9 GO:0031996 thioesterase binding(GO:0031996)
0.0 4.6 GO:0003924 GTPase activity(GO:0003924)
0.1 4.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 3.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 3.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.5 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.3 GO:0003680 AT DNA binding(GO:0003680)
0.2 2.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.8 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.4 1.7 GO:0001847 opsonin receptor activity(GO:0001847)
0.4 1.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.4 1.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 1.6 GO:0051434 BH3 domain binding(GO:0051434)
0.5 1.5 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 1.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 1.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 5.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.0 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 4.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 4.4 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 4.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 1.6 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.5 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 1.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.9 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 0.8 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 0.8 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions