Motif ID: Rfx5

Z-value: 0.580


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.625.0e-05Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 61 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_37376359 4.199 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr11_+_117523526 2.734 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr7_-_105752193 2.191 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr7_-_45091713 1.743 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092130 1.634 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_+_139150211 1.617 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr14_+_55618023 1.471 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr11_-_3539228 1.463 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr5_-_36830647 1.227 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr8_+_94214567 1.227 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr4_-_126325641 1.175 ENSMUST00000131113.1
 Tekt2
tektin 2
chr17_+_35861318 1.165 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr19_-_10482874 1.140 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr10_-_19011948 0.979 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr7_+_28180226 0.900 ENSMUST00000172467.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_-_30664986 0.839 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr11_+_61505138 0.816 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr7_+_100537052 0.810 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr19_-_4615647 0.757 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr17_+_35861343 0.722 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 2.2 GO:0043171 peptide catabolic process(GO:0043171)
0.1 2.1 GO:0007520 myoblast fusion(GO:0007520)
0.1 1.5 GO:0007141 male meiosis I(GO:0007141)
0.1 1.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 1.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.1 1.2 GO:0006013 mannose metabolic process(GO:0006013)
0.1 1.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 1.0 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.0 1.0 GO:0007338 single fertilization(GO:0007338)
0.0 0.8 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 0.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.7 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.6 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.6 GO:0060539 diaphragm development(GO:0060539)
0.1 0.5 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.5 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.4 GO:0043486 histone exchange(GO:0043486)
0.1 0.3 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.9 GO:0005652 nuclear lamina(GO:0005652)
0.4 1.5 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.1 1.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 0.8 GO:0036038 MKS complex(GO:0036038)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.0 GO:0042613 MHC class II protein complex(GO:0042613)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5 2.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 2.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 1.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 1.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 0.8 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 0.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.5 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 2.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.2 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.0 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand