Motif ID: Rfx5

Z-value: 0.580


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.625.0e-05Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_37376359 4.199 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr11_+_117523526 2.734 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr7_-_105752193 2.191 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr7_-_45091713 1.743 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092130 1.634 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_+_139150211 1.617 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr14_+_55618023 1.471 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr11_-_3539228 1.463 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr5_-_36830647 1.227 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr8_+_94214567 1.227 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr4_-_126325641 1.175 ENSMUST00000131113.1
 Tekt2
tektin 2
chr17_+_35861318 1.165 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr19_-_10482874 1.140 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr10_-_19011948 0.979 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr7_+_28180226 0.900 ENSMUST00000172467.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_-_30664986 0.839 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr11_+_61505138 0.816 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr7_+_100537052 0.810 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr19_-_4615647 0.757 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr17_+_35861343 0.722 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr7_+_28180272 0.722 ENSMUST00000173223.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_100537192 0.721 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr1_+_194619815 0.711 ENSMUST00000027952.5
 Plxna2
plexin A2
chr17_+_35379608 0.675 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr4_+_107968332 0.675 ENSMUST00000106713.3
 Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr3_+_16183177 0.658 ENSMUST00000108345.2
ENSMUST00000108346.2
 Ythdf3

YTH domain family 3

chr8_+_84969587 0.649 ENSMUST00000109734.1
ENSMUST00000005292.8
 Prdx2

peroxiredoxin 2

chr1_-_183147461 0.634 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr8_-_89187560 0.582 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr9_-_21291124 0.548 ENSMUST00000086374.6
 Cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr15_+_36179530 0.531 ENSMUST00000171205.1
 Spag1
sperm associated antigen 1
chr15_+_36179299 0.499 ENSMUST00000047348.3
 Spag1
sperm associated antigen 1
chr13_+_24831661 0.479 ENSMUST00000038039.2
 Tdp2
tyrosyl-DNA phosphodiesterase 2
chr7_+_28179469 0.469 ENSMUST00000085901.6
ENSMUST00000172761.1
 Dyrk1b

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b

chr4_-_116627921 0.442 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr17_+_35439155 0.387 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr18_-_51865881 0.383 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950
chr10_-_7663245 0.313 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr8_-_69996326 0.286 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr6_-_8259098 0.267 ENSMUST00000012627.4
 Rpa3
replication protein A3
chr2_+_163438455 0.266 ENSMUST00000109420.3
ENSMUST00000109421.3
ENSMUST00000018087.6
ENSMUST00000137070.1
 Gdap1l1



ganglioside-induced differentiation-associated protein 1-like 1



chr17_+_34145311 0.227 ENSMUST00000041982.7
 H2-DMb2
histocompatibility 2, class II, locus Mb2
chr10_-_7663569 0.217 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr1_-_155146755 0.216 ENSMUST00000027744.8
 Mr1
major histocompatibility complex, class I-related
chr7_+_44468020 0.214 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr7_+_44467980 0.201 ENSMUST00000035844.4
 Josd2
Josephin domain containing 2
chr7_-_101921186 0.198 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr7_-_101921175 0.193 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr7_-_19692596 0.169 ENSMUST00000108451.2
ENSMUST00000045035.4
 Apoc1

apolipoprotein C-I

chr6_-_29165003 0.158 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr17_+_34145231 0.148 ENSMUST00000171231.1
 H2-DMb2
histocompatibility 2, class II, locus Mb2
chr2_-_128687354 0.142 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
 Anapc1


anaphase promoting complex subunit 1


chr7_+_44468051 0.141 ENSMUST00000118493.1
 Josd2
Josephin domain containing 2
chr19_+_32757497 0.084 ENSMUST00000013807.7
 Pten
phosphatase and tensin homolog
chr17_+_34305883 0.071 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr17_+_34398802 0.069 ENSMUST00000114175.1
ENSMUST00000078615.5
ENSMUST00000139063.1
ENSMUST00000097348.2
 BC051142



cDNA sequence BC051142



chrX_-_160138375 0.062 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr3_-_95882193 0.049 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr3_-_95882232 0.042 ENSMUST00000161866.1
 Gm129
predicted gene 129
chr17_+_34263209 0.041 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr8_+_27042555 0.037 ENSMUST00000033875.8
ENSMUST00000098851.4
 Prosc

proline synthetase co-transcribed


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.3 1.0 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 1.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.1 1.2 GO:0006013 mannose metabolic process(GO:0006013)
0.1 1.5 GO:0007141 male meiosis I(GO:0007141)
0.1 1.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 1.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.6 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 0.3 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.1 2.2 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.5 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.6 GO:0060539 diaphragm development(GO:0060539)
0.1 2.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.5 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.7 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.4 GO:0043486 histone exchange(GO:0043486)
0.0 1.0 GO:0007338 single fertilization(GO:0007338)
0.0 0.8 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.0 GO:0002339 B cell selection(GO:0002339)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 1.9 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 4.2 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 0.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.3 0.8 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 1.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 3.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.5 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 1.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 1.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.2 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.7 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.0 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.5 REACTOME_G1_PHASE Genes involved in G1 Phase