Motif ID: Rhox4e_Rhox6_Vax2

Z-value: 1.449

Transcription factors associated with Rhox4e_Rhox6_Vax2:

Gene SymbolEntrez IDGene Name
Rhox4e ENSMUSG00000071770.4 Rhox4e
Rhox6 ENSMUSG00000006200.3 Rhox6
Vax2 ENSMUSG00000034777.1 Vax2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vax2mm10_v2_chr6_+_83711232_83711288-0.202.3e-01Click!


Activity profile for motif Rhox4e_Rhox6_Vax2.

activity profile for motif Rhox4e_Rhox6_Vax2


Sorted Z-values histogram for motif Rhox4e_Rhox6_Vax2

Sorted Z-values for motif Rhox4e_Rhox6_Vax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_67113909 16.579 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr6_-_23248264 12.745 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_-_14621805 10.984 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr9_+_53771499 10.190 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr4_-_14621669 7.338 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 6.502 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr14_+_5517172 6.189 ENSMUST00000178220.1
 Gm3488
predicted gene, 3488
chr14_+_5164535 6.189 ENSMUST00000179659.1
 Gm3317
predicted gene 3317
chr13_-_102906046 6.051 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr14_+_3667518 5.808 ENSMUST00000112801.3
 Gm3020
predicted gene 3020
chr7_-_25005895 5.428 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr13_-_102905740 5.123 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr14_-_5863663 4.923 ENSMUST00000178594.1
 Gm8237
predicted gene 8237
chr14_-_7473073 4.796 ENSMUST00000167833.2
 Gm3752
predicted gene 3752
chr14_+_3348089 4.774 ENSMUST00000178722.1
 Gm2956
predicted gene 2956
chr14_+_4198185 4.756 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chr16_-_42340595 4.658 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr14_-_6411578 4.568 ENSMUST00000179312.1
 Gm3591
predicted gene 3591
chr14_+_3428103 4.537 ENSMUST00000178060.1
 Gm3005
predicted gene 3005
chr14_+_4741737 4.482 ENSMUST00000178748.1
 Gm3252
predicted gene 3252

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 24.8 GO:0019532 oxalate transport(GO:0019532)
0.4 16.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
2.1 12.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 11.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 8.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.5 5.4 GO:0036376 sodium ion export from cell(GO:0036376)
0.5 4.7 GO:0016198 axon choice point recognition(GO:0016198)
0.2 4.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 3.6 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 3.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 3.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.6 2.9 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.4 2.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 2.3 GO:0034605 cellular response to heat(GO:0034605)
0.4 2.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 2.2 GO:0035329 hippo signaling(GO:0035329)
0.7 2.1 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.6 1.9 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 1.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.3 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 15.8 GO:0000139 Golgi membrane(GO:0000139)
0.8 5.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 4.7 GO:0031527 filopodium membrane(GO:0031527)
0.0 2.9 GO:0043195 terminal bouton(GO:0043195)
0.1 2.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 2.1 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.1 1.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.8 GO:0043034 costamere(GO:0043034)
0.0 1.5 GO:0000792 heterochromatin(GO:0000792)
0.0 1.5 GO:0005923 bicellular tight junction(GO:0005923)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.9 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.9 GO:0034709 methylosome(GO:0034709)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 0.8 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.8 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 24.8 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
4.1 16.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 12.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 11.2 GO:0000287 magnesium ion binding(GO:0000287)
0.5 5.4 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.7 4.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 4.1 GO:0003924 GTPase activity(GO:0003924)
0.2 3.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 2.8 GO:0019842 vitamin binding(GO:0019842)
0.0 2.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 2.3 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.6 GO:0030165 PDZ domain binding(GO:0030165)
0.3 1.2 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.2 1.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 1.1 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.0 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.1 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 1.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.9 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.7 16.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 5.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 2.1 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.1 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.9 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)