Motif ID: Rorc_Nr1d1

Z-value: 0.425

Transcription factors associated with Rorc_Nr1d1:

Gene SymbolEntrez IDGene Name
Nr1d1 ENSMUSG00000020889.11 Nr1d1
Rorc ENSMUSG00000028150.8 Rorc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1d1mm10_v2_chr11_-_98775333_98775354-0.463.8e-03Click!
Rorcmm10_v2_chr3_+_94377505_943775270.353.2e-02Click!


Activity profile for motif Rorc_Nr1d1.

activity profile for motif Rorc_Nr1d1


Sorted Z-values histogram for motif Rorc_Nr1d1

Sorted Z-values for motif Rorc_Nr1d1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rorc_Nr1d1

PNG image of the network

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Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_14310198 2.309 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr12_-_34528844 2.070 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr7_-_79386943 1.785 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr3_-_89764581 1.207 ENSMUST00000029562.3
 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr11_-_84069179 1.143 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chrX_+_103422010 1.064 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr5_+_64803513 1.029 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr11_+_94327984 0.943 ENSMUST00000107818.2
ENSMUST00000051221.6
 Ankrd40

ankyrin repeat domain 40

chr15_-_50882806 0.900 ENSMUST00000184885.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr15_-_65014904 0.796 ENSMUST00000110100.2
 Gm21961
predicted gene, 21961
chr7_+_45705088 0.755 ENSMUST00000080885.3
 Dbp
D site albumin promoter binding protein
chr13_+_6548154 0.744 ENSMUST00000021611.8
 Pitrm1
pitrilysin metallepetidase 1
chr11_+_94328242 0.732 ENSMUST00000021227.5
 Ankrd40
ankyrin repeat domain 40
chr10_+_57784859 0.639 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr6_-_93913678 0.626 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr3_-_84304762 0.501 ENSMUST00000107692.1
 Trim2
tripartite motif-containing 2
chr3_-_101307079 0.470 ENSMUST00000097146.2
 Gm10355
predicted gene 10355
chr16_-_20730544 0.461 ENSMUST00000076422.5
 Thpo
thrombopoietin
chr7_-_134232125 0.458 ENSMUST00000127524.1
 Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr6_+_61180313 0.452 ENSMUST00000126214.1
 Ccser1
coiled-coil serine rich 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 2.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 1.5 GO:0007601 visual perception(GO:0007601)
0.4 1.2 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
0.0 1.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.9 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.8 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 0.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.6 GO:0060134 prepulse inhibition(GO:0060134)
0.1 0.5 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.1 0.4 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 0.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.3 GO:0032875 regulation of DNA endoreduplication(GO:0032875) DNA endoreduplication(GO:0042023)
0.0 0.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.2 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.1 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0033391 chromatoid body(GO:0033391)
0.0 0.0 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 1.8 GO:0019841 retinol binding(GO:0019841)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.8 GO:0005179 hormone activity(GO:0005179)
0.2 0.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.6 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.5 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.3 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0034979 NAD-dependent protein deacetylase activity(GO:0034979)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 1.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.8 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.7 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)