Motif ID: Rorc_Nr1d1
Z-value: 0.425
Transcription factors associated with Rorc_Nr1d1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr1d1 | ENSMUSG00000020889.11 | Nr1d1 |
Rorc | ENSMUSG00000028150.8 | Rorc |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nr1d1 | mm10_v2_chr11_-_98775333_98775354 | -0.46 | 3.8e-03 | Click! |
Rorc | mm10_v2_chr3_+_94377505_94377527 | 0.35 | 3.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.2 | GO:0060084 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084) |
0.4 | 2.3 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
0.2 | 2.3 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
0.2 | 0.7 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.1 | 0.4 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
0.1 | 0.5 | GO:0038163 | thrombopoietin-mediated signaling pathway(GO:0038163) |
0.1 | 0.4 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
0.1 | 0.1 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
0.1 | 0.2 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
0.1 | 0.2 | GO:0050859 | regulation of activation of Janus kinase activity(GO:0010533) negative regulation of serotonin secretion(GO:0014063) negative regulation of B cell receptor signaling pathway(GO:0050859) regulation of eosinophil activation(GO:1902566) negative regulation of membrane invagination(GO:1905154) |
0.1 | 0.2 | GO:2000508 | regulation of dendritic cell chemotaxis(GO:2000508) |
0.1 | 0.8 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.0 | 0.3 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
0.0 | 0.3 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.0 | 0.1 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
0.0 | 0.1 | GO:0006578 | amino-acid betaine biosynthetic process(GO:0006578) |
0.0 | 0.9 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 0.6 | GO:0060134 | prepulse inhibition(GO:0060134) |
0.0 | 1.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.0 | 0.1 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
0.0 | 0.3 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
0.0 | 0.4 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
0.0 | 0.3 | GO:0032875 | regulation of DNA endoreduplication(GO:0032875) DNA endoreduplication(GO:0042023) |
0.0 | 0.1 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) |
0.0 | 0.1 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
0.0 | 0.3 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
0.0 | 0.1 | GO:0071105 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
0.0 | 0.8 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
0.0 | 1.5 | GO:0007601 | visual perception(GO:0007601) |
0.0 | 0.2 | GO:0016246 | RNA interference(GO:0016246) |
0.0 | 0.1 | GO:2000194 | regulation of female gonad development(GO:2000194) |
0.0 | 0.0 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.4 | GO:0033391 | chromatoid body(GO:0033391) |
0.0 | 2.1 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
0.0 | 2.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.0 | 0.0 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
0.0 | 0.0 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.8 | GO:0019841 | retinol binding(GO:0019841) |
0.2 | 0.7 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.1 | 0.8 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.1 | 1.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.1 | 0.3 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
0.1 | 2.1 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.1 | 1.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.0 | 0.2 | GO:0034979 | NAD-dependent protein deacetylase activity(GO:0034979) |
0.0 | 0.4 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
0.0 | 0.6 | GO:0051393 | alpha-actinin binding(GO:0051393) |
0.0 | 0.1 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
0.0 | 0.1 | GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity(GO:0070991) |
0.0 | 0.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.0 | 0.2 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
0.0 | 0.2 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
0.0 | 2.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
0.0 | 1.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.1 | GO:0019863 | IgE binding(GO:0019863) |
0.0 | 0.5 | GO:0005504 | fatty acid binding(GO:0005504) |
0.0 | 0.0 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
0.0 | 0.8 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 0.3 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
0.0 | 0.5 | GO:0005109 | frizzled binding(GO:0005109) |
0.0 | 0.1 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
0.0 | 0.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.1 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
0.0 | 0.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 0.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.2 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.0 | 0.7 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.0 | 1.1 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.0 | 2.1 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 0.5 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.0 | 0.8 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
0.0 | 0.3 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |