Motif ID: Runx1

Z-value: 0.852


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66801577 12.252 ENSMUST00000168589.1
Sla
src-like adaptor
chr17_+_3397189 6.250 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr4_-_14621805 5.340 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr13_+_76579670 4.563 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1

multiple C2 domains, transmembrane 1

chr5_+_104435112 4.360 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
Spp1





secreted phosphoprotein 1





chr16_+_42907563 3.984 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr15_-_37459327 3.726 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr11_-_83649349 3.677 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr2_+_37516618 3.625 ENSMUST00000065441.6
Gpr21
G protein-coupled receptor 21
chr13_+_49608030 3.272 ENSMUST00000021822.5
Ogn
osteoglycin
chr6_+_17491216 3.167 ENSMUST00000080469.5
Met
met proto-oncogene
chr3_-_107760221 3.123 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr8_-_11008458 3.085 ENSMUST00000040514.6
Irs2
insulin receptor substrate 2
chr12_-_25096080 3.073 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr11_-_52282564 3.068 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr11_-_110168073 2.861 ENSMUST00000044850.3
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr14_-_124677089 2.861 ENSMUST00000095529.3
Fgf14
fibroblast growth factor 14
chr4_-_14621494 2.794 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr15_-_76090013 2.768 ENSMUST00000019516.4
Nrbp2
nuclear receptor binding protein 2
chr17_+_35236556 2.743 ENSMUST00000068261.8
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chrX_+_151344171 2.737 ENSMUST00000073364.5
Fam120c
family with sequence similarity 120, member C
chr1_-_140183404 2.727 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr7_-_90129339 2.723 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr4_-_14621669 2.604 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr1_-_169747634 2.494 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr1_-_140183283 2.347 ENSMUST00000111977.1
Cfh
complement component factor h
chr8_+_76902277 2.157 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr14_-_66280949 2.055 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
Ptk2b


PTK2 protein tyrosine kinase 2 beta


chr4_-_6990774 1.944 ENSMUST00000039987.3
Tox
thymocyte selection-associated high mobility group box
chr16_+_91391721 1.810 ENSMUST00000160764.1
Gm21970
predicted gene 21970
chr15_+_62037986 1.792 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr3_-_142169311 1.747 ENSMUST00000106230.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chrX_+_159697308 1.743 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr2_+_32629467 1.535 ENSMUST00000068271.4
Ak1
adenylate kinase 1
chr6_+_17749170 1.508 ENSMUST00000053148.7
ENSMUST00000115417.3
St7

suppression of tumorigenicity 7

chr10_-_40302186 1.504 ENSMUST00000099945.4
Amd1
S-adenosylmethionine decarboxylase 1
chrX_-_48034842 1.449 ENSMUST00000039026.7
Apln
apelin
chr1_-_168431896 1.292 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr16_+_43510267 1.277 ENSMUST00000114695.2
Zbtb20
zinc finger and BTB domain containing 20
chr11_-_79530569 1.246 ENSMUST00000103236.3
ENSMUST00000170799.1
ENSMUST00000170422.2
Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chrX_+_56786527 1.226 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr2_+_18672384 1.196 ENSMUST00000171845.1
ENSMUST00000061158.4
Commd3

COMM domain containing 3

chrX_-_57338598 1.188 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr8_+_105690906 1.111 ENSMUST00000062574.6
Rltpr
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr3_-_88296838 1.109 ENSMUST00000010682.3
Tsacc
TSSK6 activating co-chaperone
chr1_-_168432270 1.101 ENSMUST00000072863.4
Pbx1
pre B cell leukemia homeobox 1
chr2_+_164948219 1.090 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr15_-_102722120 1.087 ENSMUST00000171838.1
Calcoco1
calcium binding and coiled coil domain 1
chr15_+_9436028 1.026 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr2_-_52558539 0.990 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr19_+_5568002 0.989 ENSMUST00000096318.3
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr3_-_88296979 0.968 ENSMUST00000107556.3
Tsacc
TSSK6 activating co-chaperone
chr15_-_102722150 0.958 ENSMUST00000023818.3
Calcoco1
calcium binding and coiled coil domain 1
chr1_+_152399824 0.933 ENSMUST00000044311.8
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr3_+_96181151 0.763 ENSMUST00000035371.8
Sv2a
synaptic vesicle glycoprotein 2 a
chr19_-_10880370 0.759 ENSMUST00000133303.1
Tmem109
transmembrane protein 109
chr18_+_37411674 0.752 ENSMUST00000051126.2
Pcdhb10
protocadherin beta 10
chr2_+_164460945 0.719 ENSMUST00000072452.4
Sys1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr12_+_95692212 0.706 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr9_+_113812547 0.700 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr4_-_70410422 0.679 ENSMUST00000144099.1
Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr14_+_31641051 0.670 ENSMUST00000090147.6
Btd
biotinidase
chr2_-_32741016 0.654 ENSMUST00000009695.2
6330409D20Rik
RIKEN cDNA 6330409D20 gene
chr7_+_44572370 0.628 ENSMUST00000002274.8
Napsa
napsin A aspartic peptidase
chr6_-_136941694 0.612 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_-_99096196 0.611 ENSMUST00000175886.1
Foxp1
forkhead box P1
chr6_-_136941494 0.592 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_32721055 0.554 ENSMUST00000074248.4
Sh2d3c
SH2 domain containing 3C
chr6_+_136518820 0.551 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr2_-_26021532 0.548 ENSMUST00000136750.1
Ubac1
ubiquitin associated domain containing 1
chr6_+_21985903 0.537 ENSMUST00000137437.1
ENSMUST00000115383.2
Cped1

cadherin-like and PC-esterase domain containing 1

chr15_-_38519227 0.518 ENSMUST00000110328.1
ENSMUST00000110329.1
ENSMUST00000065308.5
Azin1


antizyme inhibitor 1


chr11_+_116030304 0.479 ENSMUST00000021116.5
ENSMUST00000106452.1
Unk

unkempt homolog (Drosophila)

chr1_+_160044374 0.447 ENSMUST00000163892.1
4930523C07Rik
RIKEN cDNA 4930523C07 gene
chr12_+_10390756 0.442 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr2_-_116065798 0.430 ENSMUST00000110907.1
ENSMUST00000110908.2
Meis2

Meis homeobox 2

chr8_+_34327910 0.425 ENSMUST00000075321.6
Gm4889
predicted gene 4889
chr17_+_47596061 0.419 ENSMUST00000182539.1
Ccnd3
cyclin D3
chrX_+_48623737 0.411 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chrX_-_20950597 0.406 ENSMUST00000009550.7
Elk1
ELK1, member of ETS oncogene family
chr2_-_26021679 0.401 ENSMUST00000036509.7
Ubac1
ubiquitin associated domain containing 1
chr4_-_152038568 0.390 ENSMUST00000030792.1
Tas1r1
taste receptor, type 1, member 1
chr18_-_60648290 0.384 ENSMUST00000143275.2
Synpo
synaptopodin
chr10_+_19934472 0.365 ENSMUST00000095806.3
ENSMUST00000120259.1
Map3k5

mitogen-activated protein kinase kinase kinase 5

chr19_+_8839298 0.365 ENSMUST00000160556.1
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr8_-_95434869 0.345 ENSMUST00000034249.6
Gtl3
gene trap locus 3
chr4_+_102760294 0.320 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr17_-_90455872 0.309 ENSMUST00000174337.1
ENSMUST00000172466.1
Nrxn1

neurexin I

chr1_+_36307745 0.291 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
Arid5a





AT rich interactive domain 5A (MRF1-like)





chr7_-_133709051 0.287 ENSMUST00000124759.1
ENSMUST00000106144.1
Uros

uroporphyrinogen III synthase

chr7_-_43533171 0.281 ENSMUST00000004728.5
ENSMUST00000039861.5
Cd33

CD33 antigen

chrX_+_7579666 0.242 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr1_+_160044564 0.235 ENSMUST00000168359.1
4930523C07Rik
RIKEN cDNA 4930523C07 gene
chr3_+_121291725 0.235 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr15_-_98607611 0.231 ENSMUST00000096224.4
Adcy6
adenylate cyclase 6
chr5_-_92328068 0.226 ENSMUST00000113093.3
Cxcl9
chemokine (C-X-C motif) ligand 9
chr16_+_18877037 0.225 ENSMUST00000120532.1
ENSMUST00000004222.7
Hira

histone cell cycle regulation defective homolog A (S. cerevisiae)

chr4_-_46404224 0.208 ENSMUST00000107764.2
Hemgn
hemogen
chr12_+_116077720 0.189 ENSMUST00000011315.3
Vipr2
vasoactive intestinal peptide receptor 2
chr7_-_133708958 0.170 ENSMUST00000106146.1
Uros
uroporphyrinogen III synthase
chr3_-_86142684 0.159 ENSMUST00000029722.6
Rps3a1
ribosomal protein S3A1
chr1_+_34160253 0.158 ENSMUST00000183302.1
Dst
dystonin
chr2_-_71367749 0.143 ENSMUST00000151937.1
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr2_-_52335134 0.142 ENSMUST00000075301.3
Neb
nebulin
chrX_-_8090442 0.126 ENSMUST00000033505.6
Was
Wiskott-Aldrich syndrome homolog (human)
chr2_-_148045891 0.122 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr14_-_20618339 0.120 ENSMUST00000035340.7
Usp54
ubiquitin specific peptidase 54
chr15_-_97844254 0.116 ENSMUST00000119670.1
ENSMUST00000116409.2
Hdac7

histone deacetylase 7

chr17_+_24896488 0.109 ENSMUST00000024978.6
Nme3
NME/NM23 nucleoside diphosphate kinase 3
chr10_-_14718191 0.099 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr7_-_133709069 0.095 ENSMUST00000106145.3
Uros
uroporphyrinogen III synthase
chr17_+_33638056 0.071 ENSMUST00000052079.7
Pram1
PML-RAR alpha-regulated adaptor molecule 1
chr15_-_97844164 0.056 ENSMUST00000120683.1
Hdac7
histone deacetylase 7
chr3_-_89093358 0.025 ENSMUST00000090929.5
ENSMUST00000052539.6
Rusc1

RUN and SH3 domain containing 1

chr7_+_133709333 0.020 ENSMUST00000033282.4
Bccip
BRCA2 and CDKN1A interacting protein
chr8_+_94386438 0.006 ENSMUST00000161576.1
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 10.7 GO:0019532 oxalate transport(GO:0019532)
1.1 4.4 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
1.0 3.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.8 5.1 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.7 2.1 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.6 3.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.6 2.9 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.5 1.5 GO:0006597 spermine biosynthetic process(GO:0006597)
0.5 1.4 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.5 3.2 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 1.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.4 3.7 GO:0043615 astrocyte cell migration(GO:0043615)
0.4 3.1 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.3 3.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.3 1.5 GO:0046103 ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103)
0.2 1.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.2 1.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 0.5 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.2 12.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.6 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.1 5.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.4 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 2.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.6 GO:0043129 surfactant homeostasis(GO:0043129)
0.1 0.2 GO:0032714 negative regulation of T cell cytokine production(GO:0002725) negative regulation of interleukin-5 production(GO:0032714)
0.1 0.7 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 1.0 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.7 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 3.6 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.1 2.4 GO:0030325 adrenal gland development(GO:0030325)
0.1 0.3 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.3 GO:2000318 positive regulation of interferon-gamma secretion(GO:1902715) positive regulation of T-helper 17 type immune response(GO:2000318)
0.1 0.7 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 0.1 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.1 0.6 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 0.8 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.1 0.2 GO:0035811 negative regulation of urine volume(GO:0035811)
0.1 2.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 3.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 6.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.0 0.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.7 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 1.2 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 1.2 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.4 GO:0050909 sensory perception of taste(GO:0050909)
0.0 2.6 GO:0015992 proton transport(GO:0015992)
0.0 0.4 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.0 0.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 2.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 2.0 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 0.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 1.7 GO:0008360 regulation of cell shape(GO:0008360)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 1.5 GO:0001520 outer dense fiber(GO:0001520)
0.2 0.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 2.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 2.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 11.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.4 GO:0097444 spine apparatus(GO:0097444)
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 3.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 4.8 GO:0072562 blood microparticle(GO:0072562)
0.0 13.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.0 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.5 GO:0005844 polysome(GO:0005844)
0.0 2.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.8 GO:0016529 sarcoplasmic reticulum(GO:0016529)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0001851 complement component C3b binding(GO:0001851)
1.0 10.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.9 3.6 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.8 3.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 1.5 GO:0019808 polyamine binding(GO:0019808)
0.3 1.8 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.3 14.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 2.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 1.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 3.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 3.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.4 GO:0008527 taste receptor activity(GO:0008527)
0.1 3.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.5 GO:0042979 ornithine decarboxylase regulator activity(GO:0042979)
0.1 2.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 7.7 GO:0005125 cytokine activity(GO:0005125)
0.1 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 2.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 7.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.3 GO:0008083 growth factor activity(GO:0008083)
0.1 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.5 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 1.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 2.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.4 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 2.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.9 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 3.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 4.2 GO:0044325 ion channel binding(GO:0044325)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 7.5 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.1 3.2 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 7.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 3.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 3.1 PID_EPO_PATHWAY EPO signaling pathway
0.1 11.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 6.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 2.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 3.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 3.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 2.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 3.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 7.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 8.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.2 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 3.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.1 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases