Motif ID: Runx2_Bcl11a

Z-value: 1.317

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24078111_240781340.231.8e-01Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 13.818 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr15_-_66801577 10.084 ENSMUST00000168589.1
 Sla
src-like adaptor
chr11_-_83649349 7.853 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr4_-_136892867 7.224 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr8_-_11008458 6.795 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr19_+_3935186 6.648 ENSMUST00000162708.1
ENSMUST00000165711.1
 Unc93b1

unc-93 homolog B1 (C. elegans)

chr3_-_87263518 6.402 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_172297989 6.040 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr1_+_58210397 6.006 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr4_+_144892813 5.670 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr5_-_77408034 5.506 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chr1_-_140183404 5.498 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr5_+_90772435 5.262 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr11_+_101246960 5.192 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr15_+_3270767 5.054 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr15_-_37459327 4.634 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr13_-_37050237 4.561 ENSMUST00000164727.1
 F13a1
coagulation factor XIII, A1 subunit
chr5_+_37047464 4.474 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chrX_+_159697308 4.447 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr11_-_106388066 4.422 ENSMUST00000106813.2
ENSMUST00000141146.1
 Icam2

intercellular adhesion molecule 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 290 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.0 GO:0042572 retinol metabolic process(GO:0042572)
0.1 9.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.0 9.0 GO:0043615 astrocyte cell migration(GO:0043615)
1.4 8.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 7.9 GO:0007416 synapse assembly(GO:0007416)
1.0 7.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.0 7.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 6.7 GO:0030032 lamellipodium assembly(GO:0030032)
1.3 6.6 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.7 6.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 6.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
2.0 6.0 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
2.0 6.0 GO:0046110 xanthine metabolic process(GO:0046110)
1.1 5.6 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.8 5.6 GO:0019532 oxalate transport(GO:0019532)
1.1 5.3 GO:0045347 regulation of cytolysis(GO:0042268) negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.9 5.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.7 5.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.6 4.9 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.4 4.9 GO:0051923 sulfation(GO:0051923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.3 GO:0072562 blood microparticle(GO:0072562)
3.5 13.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 11.5 GO:0005615 extracellular space(GO:0005615)
0.1 10.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 9.7 GO:0045177 apical part of cell(GO:0045177)
0.9 8.7 GO:0032009 early phagosome(GO:0032009)
0.1 7.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 6.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.5 5.7 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
1.0 5.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.6 4.9 GO:0042629 mast cell granule(GO:0042629)
0.2 4.5 GO:0005604 basement membrane(GO:0005604)
0.5 4.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 4.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 3.8 GO:0048786 presynaptic active zone(GO:0048786)
0.1 3.6 GO:0009925 basal plasma membrane(GO:0009925)
0.7 3.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 3.3 GO:0043204 perikaryon(GO:0043204)
0.1 3.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 13.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.6 10.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 9.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 8.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.5 8.4 GO:0050811 GABA receptor binding(GO:0050811)
2.1 8.3 GO:0001851 complement component C3b binding(GO:0001851)
0.1 7.1 GO:0008083 growth factor activity(GO:0008083)
0.2 7.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 7.0 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 6.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.7 6.5 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.4 6.4 GO:0035325 Toll-like receptor binding(GO:0035325)
1.5 6.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.2 6.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 5.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.8 5.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.1 5.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.0 5.2 GO:0097643 amylin receptor activity(GO:0097643)
0.2 5.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
1.6 4.9 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 31.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 10.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.9 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.2 6.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 6.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 5.5 PID_FGF_PATHWAY FGF signaling pathway
0.2 5.3 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 5.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 5.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 5.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.8 PID_SHP2_PATHWAY SHP2 signaling
0.4 4.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 4.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 3.3 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 3.0 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 2.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 2.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 2.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
2.0 9.8 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
1.7 8.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.5 8.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 8.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.3 7.9 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 6.9 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.7 6.6 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 6.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 5.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 5.8 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 5.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 5.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.7 4.9 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 4.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 4.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 4.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 4.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 4.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 3.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation