Motif ID: Scrt2

Z-value: 0.992


Transcription factors associated with Scrt2:

Gene SymbolEntrez IDGene Name
Scrt2 ENSMUSG00000060257.2 Scrt2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt2mm10_v2_chr2_+_152081529_152081624-0.624.7e-05Click!


Activity profile for motif Scrt2.

activity profile for motif Scrt2


Sorted Z-values histogram for motif Scrt2

Sorted Z-values for motif Scrt2



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt2

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_111066154 7.086 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_-_53657339 6.217 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr7_+_126847908 4.743 ENSMUST00000147257.1
ENSMUST00000139174.1
 Doc2a

double C2, alpha

chr5_+_118169712 4.581 ENSMUST00000054836.6
 Hrk
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr15_-_71727815 4.553 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr12_-_4592927 4.514 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr17_-_25570678 4.203 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr9_+_45370185 4.191 ENSMUST00000085939.6
 Fxyd6
FXYD domain-containing ion transport regulator 6
chr8_+_76902277 3.871 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr11_-_55419898 3.635 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr16_+_42907563 3.619 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr8_-_71537402 3.450 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr18_-_58209926 3.366 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr15_+_34306666 3.148 ENSMUST00000163455.2
ENSMUST00000022947.5
 Matn2

matrilin 2

chr19_-_57008187 3.118 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr7_+_81523531 3.090 ENSMUST00000181903.1
 2900076A07Rik
RIKEN cDNA 2900076A07 gene
chr18_-_82406777 3.025 ENSMUST00000065224.6
 Galr1
galanin receptor 1
chr12_-_40037387 2.868 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr7_+_81523555 2.553 ENSMUST00000180385.1
ENSMUST00000180879.1
ENSMUST00000181164.1
ENSMUST00000181264.1
 2900076A07Rik



RIKEN cDNA 2900076A07 gene



chr4_-_119538769 2.455 ENSMUST00000079611.6
 AA415398
expressed sequence AA415398

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.9 4.6 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 4.6 GO:0048839 inner ear development(GO:0048839)
1.4 4.2 GO:0072034 renal vesicle induction(GO:0072034)
0.1 4.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 4.2 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2 3.9 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 3.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 3.6 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.9 3.5 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.7 3.4 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.1 3.1 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.1 3.1 GO:0031102 neuron projection regeneration(GO:0031102) response to axon injury(GO:0048678)
1.0 3.0 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.1 2.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.5 2.3 GO:0015822 ornithine transport(GO:0015822)
0.2 2.1 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.6 1.9 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.2 1.9 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 1.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0005604 basement membrane(GO:0005604)
0.2 7.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 7.0 GO:0070382 exocytic vesicle(GO:0070382)
0.0 3.9 GO:0043235 receptor complex(GO:0043235)
0.9 3.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.3 3.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.3 GO:0031941 filamentous actin(GO:0031941)
0.0 1.9 GO:0001650 fibrillar center(GO:0001650)
0.0 1.8 GO:0055037 recycling endosome(GO:0055037)
0.4 1.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.3 1.4 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.4 GO:0031045 dense core granule(GO:0031045)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.2 1.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.3 GO:0042555 MCM complex(GO:0042555)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 1.1 GO:0000243 commitment complex(GO:0000243)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 6.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 5.4 GO:0005518 collagen binding(GO:0005518)
0.0 4.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 4.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 4.2 GO:0003924 GTPase activity(GO:0003924)
0.1 3.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 3.7 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.3 3.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 3.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.8 3.0 GO:0004966 galanin receptor activity(GO:0004966)
0.6 2.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 2.3 GO:0008013 beta-catenin binding(GO:0008013)
0.6 1.9 GO:0019002 GMP binding(GO:0019002)
0.2 1.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 1.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.3 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.1 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism