Motif ID: Sin3a

Z-value: 1.268


Transcription factors associated with Sin3a:

Gene SymbolEntrez IDGene Name
Sin3a ENSMUSG00000042557.8 Sin3a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sin3amm10_v2_chr9_+_57076395_570764110.802.9e-09Click!


Activity profile for motif Sin3a.

activity profile for motif Sin3a


Sorted Z-values histogram for motif Sin3a

Sorted Z-values for motif Sin3a



Network of associatons between targets according to the STRING database.



First level regulatory network of Sin3a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_64340225 11.905 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr14_-_98169542 9.883 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr9_+_118478851 9.612 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr6_-_39206782 8.783 ENSMUST00000002305.8
 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr2_-_34372004 8.396 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr19_+_59458372 7.764 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr5_-_106458440 6.886 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chrX_+_58030999 6.795 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr3_-_52104891 6.753 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr14_+_122475397 6.400 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr10_-_120476469 5.882 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr6_+_34745952 5.808 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
 Cald1


caldesmon 1


chr6_+_34746368 5.125 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr17_-_35703971 4.982 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr19_+_25610533 4.910 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr17_-_35704000 4.774 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr18_-_72351009 4.711 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr3_-_116423930 4.702 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr2_-_84775388 4.687 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr3_-_116424007 4.686 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 546 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 14.4 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
4.3 12.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.1 11.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 11.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 10.6 GO:0006334 nucleosome assembly(GO:0006334)
3.3 9.9 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.1 9.9 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.8 9.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 9.7 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.9 9.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
3.1 9.3 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.7 8.7 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.5 7.7 GO:0006337 nucleosome disassembly(GO:0006337)
1.3 7.6 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.6 7.3 GO:0001675 acrosome assembly(GO:0001675)
2.3 7.0 GO:0030421 defecation(GO:0030421)
0.4 7.0 GO:0021516 dorsal spinal cord development(GO:0021516)
1.1 6.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.8 6.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
1.6 6.4 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 57.0 GO:0005634 nucleus(GO:0005634)
0.0 32.7 GO:0005654 nucleoplasm(GO:0005654)
0.1 20.8 GO:0016607 nuclear speck(GO:0016607)
0.3 19.7 GO:0005844 polysome(GO:0005844)
0.1 16.3 GO:0005814 centriole(GO:0005814)
0.1 12.4 GO:0005923 bicellular tight junction(GO:0005923)
1.3 11.8 GO:0030478 actin cap(GO:0030478)
0.6 11.5 GO:0097470 ribbon synapse(GO:0097470)
0.3 10.8 GO:0090544 BAF-type complex(GO:0090544)
0.1 10.8 GO:0016605 PML body(GO:0016605)
0.1 10.4 GO:0000922 spindle pole(GO:0000922)
0.1 9.1 GO:0000786 nucleosome(GO:0000786)
0.7 8.0 GO:0032584 growth cone membrane(GO:0032584)
0.1 7.8 GO:0072562 blood microparticle(GO:0072562)
1.9 7.6 GO:0060187 cell pole(GO:0060187)
0.1 7.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 7.6 GO:0016604 nuclear body(GO:0016604)
0.5 6.2 GO:0097542 ciliary tip(GO:0097542)
0.0 5.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 5.1 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 302 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 52.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 19.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.6 17.3 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.1 13.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 12.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.6 11.6 GO:0001848 complement binding(GO:0001848)
1.4 11.5 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.3 10.5 GO:0046790 virion binding(GO:0046790)
1.7 10.4 GO:0005042 netrin receptor activity(GO:0005042)
1.3 10.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.1 9.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.6 9.3 GO:0003680 AT DNA binding(GO:0003680)
0.3 8.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 8.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 8.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.0 7.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 6.4 GO:0001972 retinoic acid binding(GO:0001972)
0.2 6.3 GO:0070840 dynein complex binding(GO:0070840)
2.0 6.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 6.0 GO:0004402 histone acetyltransferase activity(GO:0004402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 15.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 14.3 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 14.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 11.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 11.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 11.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 7.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 7.3 PID_PLK1_PATHWAY PLK1 signaling events
0.2 7.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 6.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.4 5.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 5.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 5.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 4.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 4.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 4.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 3.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 3.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 13.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.3 10.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.5 9.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.9 9.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.5 9.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.8 9.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 8.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 6.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 6.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 5.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 5.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 5.0 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 4.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 4.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 4.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 4.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 3.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 3.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 3.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression