Motif ID: Six3_Six1_Six2

Z-value: 0.860

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six1mm10_v2_chr12_-_73047179_730471790.464.0e-03Click!
Six2mm10_v2_chr17_-_85688252_856882750.325.4e-02Click!
Six3mm10_v2_chr17_+_85621017_856210310.115.2e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 67 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_85722474 8.399 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr13_+_94083490 6.102 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr1_+_139454747 4.130 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr15_-_75894474 4.059 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_-_126676357 3.689 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chrX_-_142966709 3.353 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_+_139423151 3.342 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr7_-_126676428 2.817 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chrX_+_169685191 2.808 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr9_+_72958785 2.637 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr9_+_65141154 2.309 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr18_+_56432116 2.301 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr4_-_32950813 2.054 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr15_-_82244716 1.789 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr7_-_80115294 1.653 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr3_+_94398517 1.639 ENSMUST00000050975.3
 Lingo4
leucine rich repeat and Ig domain containing 4
chr8_+_57455898 1.375 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr15_+_98571004 1.262 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr8_-_4275886 0.928 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr3_+_88207308 0.860 ENSMUST00000180582.1
 Gm3764
predicted gene 3764

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.5 GO:0051923 sulfation(GO:0051923)
0.8 4.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.8 3.3 GO:1904706 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.3 2.8 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 2.6 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.1 2.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.6 1.7 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.0 1.7 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.2 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.1 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 0.8 GO:0046208 spermine catabolic process(GO:0046208)
0.2 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469) maintenance of organ identity(GO:0048496)
0.1 0.6 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 0.6 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.5 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.4 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.8 4.1 GO:0036449 microtubule minus-end(GO:0036449)
0.3 3.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 2.4 GO:0000776 kinetochore(GO:0000776)
0.3 1.3 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.8 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 0.6 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 0.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 6.5 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 4.1 GO:0005516 calmodulin binding(GO:0005516)
0.6 3.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 2.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 2.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.6 1.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 1.3 GO:0019215 intermediate filament binding(GO:0019215)
0.3 0.8 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.6 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.5 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.1 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters