Motif ID: Six3_Six1_Six2

Z-value: 0.860

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six1mm10_v2_chr12_-_73047179_730471790.464.0e-03Click!
Six2mm10_v2_chr17_-_85688252_856882750.325.4e-02Click!
Six3mm10_v2_chr17_+_85621017_856210310.115.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_85722474 8.399 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr13_+_94083490 6.102 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr1_+_139454747 4.130 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr15_-_75894474 4.059 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_-_126676357 3.689 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chrX_-_142966709 3.353 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_+_139423151 3.342 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr7_-_126676428 2.817 ENSMUST00000106373.1
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chrX_+_169685191 2.808 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr9_+_72958785 2.637 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr9_+_65141154 2.309 ENSMUST00000034961.4
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr18_+_56432116 2.301 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr4_-_32950813 2.054 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr15_-_82244716 1.789 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr7_-_80115294 1.653 ENSMUST00000107384.3
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr3_+_94398517 1.639 ENSMUST00000050975.3
Lingo4
leucine rich repeat and Ig domain containing 4
chr8_+_57455898 1.375 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr15_+_98571004 1.262 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr8_-_4275886 0.928 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr3_+_88207308 0.860 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr6_+_48537560 0.797 ENSMUST00000040361.5
Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr2_+_131491764 0.776 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr17_-_56716788 0.752 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr7_-_141168671 0.648 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chr11_-_69695521 0.638 ENSMUST00000181261.1
Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr5_-_106926245 0.631 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr2_-_13271419 0.627 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr13_+_104229366 0.618 ENSMUST00000022227.6
Cenpk
centromere protein K
chr2_-_13271268 0.601 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr1_+_136467958 0.597 ENSMUST00000047817.6
Kif14
kinesin family member 14
chr9_+_104002546 0.562 ENSMUST00000035167.8
ENSMUST00000117054.1
Nphp3

nephronophthisis 3 (adolescent)

chr19_-_23075853 0.538 ENSMUST00000181623.1
C330002G04Rik
RIKEN cDNA C330002G04 gene
chr17_-_56717681 0.511 ENSMUST00000164907.1
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr10_+_24595623 0.502 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr10_+_100488289 0.501 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr3_-_37724321 0.424 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr4_+_11758147 0.418 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr17_-_53539411 0.401 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr4_+_133176336 0.359 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr7_+_123123870 0.351 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr1_-_118982551 0.323 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr15_-_76206309 0.256 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
Plec


plectin


chr12_+_30584429 0.237 ENSMUST00000057151.8
Tmem18
transmembrane protein 18
chr6_+_38534823 0.237 ENSMUST00000019833.4
1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr10_-_78487842 0.215 ENSMUST00000069431.4
Gm9978
predicted gene 9978
chr17_+_40811089 0.206 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr2_+_106693185 0.200 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr2_+_127336152 0.178 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr14_+_57798182 0.170 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chr12_+_84773262 0.169 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr14_+_123659971 0.132 ENSMUST00000049681.7
Itgbl1
integrin, beta-like 1
chr5_+_21543525 0.126 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr8_+_69832633 0.121 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr8_+_71951038 0.111 ENSMUST00000131237.1
ENSMUST00000136516.1
ENSMUST00000109997.2
ENSMUST00000132848.1
Zfp961



zinc finger protein 961



chr4_-_43030440 0.088 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr3_+_130068390 0.081 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr7_+_30232310 0.074 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr5_-_62765618 0.063 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_+_57798156 0.056 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18
chr16_+_11203375 0.039 ENSMUST00000181526.1
2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr9_+_119341487 0.037 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr11_-_101987004 0.025 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr17_+_35241838 0.024 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr11_-_87826023 0.022 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr7_+_30231884 0.016 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr3_+_146220955 0.013 ENSMUST00000039164.2
Lpar3
lysophosphatidic acid receptor 3
chr11_-_99230998 0.010 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:1904706 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.8 4.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.6 6.5 GO:0051923 sulfation(GO:0051923)
0.6 1.7 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.3 2.8 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 2.6 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.2 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469) maintenance of organ identity(GO:0048496)
0.2 0.8 GO:0046208 spermine catabolic process(GO:0046208)
0.1 0.6 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 2.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.5 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.3 GO:0060032 notochord regression(GO:0060032)
0.1 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.6 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.1 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 0.1 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.4 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 1.7 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 1.2 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0036449 microtubule minus-end(GO:0036449)
0.3 3.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.3 1.3 GO:0045098 type III intermediate filament(GO:0045098)
0.2 0.6 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 0.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 5.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)
0.0 2.4 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.6 3.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.6 1.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 0.8 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 1.3 GO:0019215 intermediate filament binding(GO:0019215)
0.1 0.6 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 2.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 2.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 4.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.2 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters