ISMARA results: Six6

Motif ID: Six6

Z-value: 0.474

Transcription factors associated with Six6:

Gene Symbol	Entrez ID	Gene Name
Six6	ENSMUSG00000021099.5	Six6

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Six6	mm10_v2_chr12_+_72939724_72939758	0.06	7.3e-01	Click!

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Top targets:

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Showing 1 to 20 of 171 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_57455898	1.098	ENSMUST00000034023.3	Scrg1	scrapie responsive gene 1
chr1_+_139454747	1.053	ENSMUST00000053364.8 ENSMUST00000097554.3	Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr11_+_78324200	0.883	ENSMUST00000102478.3	Aldoc	aldolase C, fructose-bisphosphate
chr5_+_140607334	0.780	ENSMUST00000031555.1	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_-_142966709	0.770	ENSMUST00000041317.2	Ammecr1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr4_-_43653542	0.759	ENSMUST00000084646.4	Spag8	sperm associated antigen 8
chrX_+_103414461	0.729	ENSMUST00000033691.4	Tsx	testis specific X-linked gene
chr17_+_43568269	0.714	ENSMUST00000024706.5	Pla2g7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_-_75894474	0.710	ENSMUST00000023237.6	Naprt1	nicotinate phosphoribosyltransferase domain containing 1
chr3_+_88207308	0.706	ENSMUST00000180582.1	Gm3764	predicted gene 3764
chr4_+_156013835	0.701	ENSMUST00000030952.5	Tnfrsf4	tumor necrosis factor receptor superfamily, member 4
chr17_+_43568641	0.692	ENSMUST00000169694.1	Pla2g7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr7_-_126676357	0.687	ENSMUST00000106371.1 ENSMUST00000106372.3 ENSMUST00000155419.1	Sult1a1	sulfotransferase family 1A, phenol-preferring, member 1
chrX_+_169685191	0.680	ENSMUST00000112104.1 ENSMUST00000112107.1	Mid1	midline 1
chr10_+_24595623	0.679	ENSMUST00000176228.1 ENSMUST00000129142.1	Ctgf	connective tissue growth factor
chr17_+_43568096	0.673	ENSMUST00000167214.1	Pla2g7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr4_-_43653560	0.670	ENSMUST00000107870.2	Spag8	sperm associated antigen 8
chr7_-_126676428	0.599	ENSMUST00000106373.1	Sult1a1	sulfotransferase family 1A, phenol-preferring, member 1
chr3_-_85887472	0.596	ENSMUST00000033643.5 ENSMUST00000154148.1	Glt28d2 Arfip1	glycosyltransferase 28 domain containing 2 ADP-ribosylation factor interacting protein 1
chr19_+_4154606	0.580	ENSMUST00000061086.8	Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 61 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.5	GO:0034441	plasma lipoprotein particle oxidation(GO:0034441)
0.0	2.3	GO:0009566	fertilization(GO:0009566)
0.1	1.3	GO:0051923	sulfation(GO:0051923)
0.2	1.1	GO:0051661	maintenance of centrosome location(GO:0051661)
0.2	0.9	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.1	0.9	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2	0.8	GO:0007386	compartment pattern specification(GO:0007386)
0.2	0.7	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.1	0.7	GO:0070236	positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1	0.7	GO:0035372	protein localization to microtubule(GO:0035372)
0.1	0.6	GO:0006488	dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1	0.5	GO:0006776	vitamin A metabolic process(GO:0006776)
0.1	0.5	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.1	0.5	GO:0071474	cellular hyperosmotic response(GO:0071474)
0.1	0.4	GO:0048496	maintenance of organ identity(GO:0048496)
0.1	0.4	GO:0060032	notochord regression(GO:0060032)
0.1	0.4	GO:0046208	spermine catabolic process(GO:0046208)
0.1	0.4	GO:0032196	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1	0.4	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1	0.4	GO:0071294	cellular response to zinc ion(GO:0071294)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 24 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.5	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.2	1.1	GO:0036449	microtubule minus-end(GO:0036449)
0.0	1.1	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	1.0	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.7	GO:0005801	cis-Golgi network(GO:0005801)
0.2	0.6	GO:0043541	UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0	0.6	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	0.4	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.4	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.4	GO:0097542	ciliary tip(GO:0097542)
0.0	0.4	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.3	GO:0005688	U6 snRNP(GO:0005688)
0.0	0.3	GO:0043219	lateral loop(GO:0043219)
0.0	0.3	GO:0042555	MCM complex(GO:0042555)
0.0	0.3	GO:0001741	XY body(GO:0001741)
0.1	0.2	GO:0032311	angiogenin-PRI complex(GO:0032311)
0.0	0.2	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.2	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 30 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.5	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.4	1.3	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1	0.9	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.3	0.8	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.7	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.6	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1	0.5	GO:0019841	retinol binding(GO:0019841)
0.0	0.5	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.5	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1	0.4	GO:0046592	polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1	0.4	GO:0030171	voltage-gated proton channel activity(GO:0030171)
0.1	0.4	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
0.0	0.4	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.4	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.4	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.1	0.3	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.1	0.3	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.1	0.3	GO:0030621	U4 snRNA binding(GO:0030621)
0.0	0.3	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.3	GO:0022842	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)

Gene overrepresentation in C2:CP category:

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Showing 1 to 8 of 8 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	PID_LIS1_PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.2	PID_AMB2_NEUTROPHILS_PATHWAY	amb2 Integrin signaling
0.0	0.7	PID_CD8_TCR_DOWNSTREAM_PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.5	PID_RETINOIC_ACID_PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.4	PID_HEDGEHOG_2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.3	PID_ERBB_NETWORK_PATHWAY	ErbB receptor signaling network
0.0	0.2	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.2	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 15 of 15 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2	1.3	REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.9	REACTOME_GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.8	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.7	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	0.5	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.4	REACTOME_METABOLISM_OF_POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.4	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.4	REACTOME_REGULATION_OF_KIT_SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.4	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.3	REACTOME_UNWINDING_OF_DNA	Genes involved in Unwinding of DNA
0.0	0.3	REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.2	REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.2	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.2	REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation