Motif ID: Six6

Z-value: 0.474


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_729397580.067.3e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_57455898 1.098 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr1_+_139454747 1.053 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr11_+_78324200 0.883 ENSMUST00000102478.3
Aldoc
aldolase C, fructose-bisphosphate
chr5_+_140607334 0.780 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_-_142966709 0.770 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr4_-_43653542 0.759 ENSMUST00000084646.4
Spag8
sperm associated antigen 8
chrX_+_103414461 0.729 ENSMUST00000033691.4
Tsx
testis specific X-linked gene
chr17_+_43568269 0.714 ENSMUST00000024706.5
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_-_75894474 0.710 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr3_+_88207308 0.706 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr4_+_156013835 0.701 ENSMUST00000030952.5
Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chr17_+_43568641 0.692 ENSMUST00000169694.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr7_-_126676357 0.687 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chrX_+_169685191 0.680 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr10_+_24595623 0.679 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr17_+_43568096 0.673 ENSMUST00000167214.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr4_-_43653560 0.670 ENSMUST00000107870.2
Spag8
sperm associated antigen 8
chr7_-_126676428 0.599 ENSMUST00000106373.1
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr3_-_85887472 0.596 ENSMUST00000033643.5
ENSMUST00000154148.1
Glt28d2
Arfip1
glycosyltransferase 28 domain containing 2
ADP-ribosylation factor interacting protein 1
chr19_+_4154606 0.580 ENSMUST00000061086.8
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr16_+_84774123 0.561 ENSMUST00000114195.1
Jam2
junction adhesion molecule 2
chr9_+_98422961 0.550 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr15_-_82244716 0.546 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr4_-_97584612 0.540 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_165708088 0.531 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1

chr4_-_97584605 0.528 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr6_-_23248264 0.523 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr7_+_82611777 0.510 ENSMUST00000172784.1
Adamtsl3
ADAMTS-like 3
chr15_+_55557575 0.483 ENSMUST00000170046.1
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr15_+_55557399 0.447 ENSMUST00000022998.7
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr1_-_118982551 0.433 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr5_-_106926245 0.421 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr15_+_79895017 0.417 ENSMUST00000023054.7
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr17_-_62606679 0.417 ENSMUST00000163332.1
Efna5
ephrin A5
chr12_+_83987854 0.416 ENSMUST00000021649.7
Acot2
acyl-CoA thioesterase 2
chr9_+_72958785 0.408 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr3_-_85722474 0.406 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr17_+_43568475 0.400 ENSMUST00000167418.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr13_+_65512678 0.383 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr2_+_131491764 0.377 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr18_+_56432116 0.368 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr17_+_17316078 0.365 ENSMUST00000105311.3
Gm6712
predicted gene 6712
chr9_+_104002546 0.357 ENSMUST00000035167.8
ENSMUST00000117054.1
Nphp3

nephronophthisis 3 (adolescent)

chr18_-_88927447 0.356 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr5_+_122210134 0.352 ENSMUST00000100747.2
Hvcn1
hydrogen voltage-gated channel 1
chr13_+_94083490 0.349 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr8_+_69832633 0.343 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr1_+_97770158 0.342 ENSMUST00000112844.3
ENSMUST00000112842.1
ENSMUST00000027571.6
Gin1


gypsy retrotransposon integrase 1


chr2_-_127482499 0.334 ENSMUST00000088538.5
Kcnip3
Kv channel interacting protein 3, calsenilin
chr11_+_98412461 0.325 ENSMUST00000058295.5
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chrM_+_2743 0.311 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr11_-_106272927 0.304 ENSMUST00000021052.9
Smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr14_+_67234620 0.288 ENSMUST00000176029.1
Ebf2
early B cell factor 2
chr1_-_128359610 0.279 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr7_+_127800844 0.278 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr18_+_12599894 0.267 ENSMUST00000169401.1
Ttc39c
tetratricopeptide repeat domain 39C
chr16_+_10835046 0.265 ENSMUST00000037913.8
Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr5_+_144244432 0.260 ENSMUST00000110695.1
Bri3
brain protein I3
chr8_+_85026833 0.259 ENSMUST00000047281.8
2310036O22Rik
RIKEN cDNA 2310036O22 gene
chr15_+_55112317 0.257 ENSMUST00000096433.3
Deptor
DEP domain containing MTOR-interacting protein
chr4_+_11758147 0.255 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr10_+_73821857 0.254 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chr19_-_23075853 0.252 ENSMUST00000181623.1
C330002G04Rik
RIKEN cDNA C330002G04 gene
chr17_+_40811089 0.251 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr12_+_105705970 0.249 ENSMUST00000040876.5
Ak7
adenylate kinase 7
chr19_-_5729618 0.249 ENSMUST00000116558.2
ENSMUST00000099955.3
ENSMUST00000161368.1
Fam89b


family with sequence similarity 89, member B


chr12_+_84773262 0.248 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr7_-_42578588 0.246 ENSMUST00000179470.1
Gm21028
predicted gene, 21028
chr1_+_74713551 0.242 ENSMUST00000027356.5
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr5_+_117319258 0.219 ENSMUST00000111967.1
Vsig10
V-set and immunoglobulin domain containing 10
chr4_-_24851079 0.214 ENSMUST00000084781.5
ENSMUST00000108218.3
Klhl32

kelch-like 32

chr17_+_57279094 0.214 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
Vav1


vav 1 oncogene


chr7_-_141168671 0.212 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chrX_-_105929397 0.209 ENSMUST00000113573.1
ENSMUST00000130980.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr19_-_11336107 0.202 ENSMUST00000056035.2
ENSMUST00000067532.4
Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr7_-_130547358 0.195 ENSMUST00000160289.1
Nsmce4a
non-SMC element 4 homolog A (S. cerevisiae)
chr1_+_45311538 0.194 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr9_-_50528641 0.192 ENSMUST00000034570.5
Pts
6-pyruvoyl-tetrahydropterin synthase
chr13_-_66852017 0.189 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr2_-_13271419 0.187 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr17_-_27909206 0.187 ENSMUST00000114848.1
Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr7_+_110627650 0.185 ENSMUST00000033054.8
Adm
adrenomedullin
chr10_+_128238034 0.184 ENSMUST00000105245.2
Timeless
timeless circadian clock 1
chr2_-_13271268 0.179 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr17_+_35241838 0.176 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr16_-_65562686 0.174 ENSMUST00000004965.6
Chmp2b
charged multivesicular body protein 2B
chr3_+_94398517 0.173 ENSMUST00000050975.3
Lingo4
leucine rich repeat and Ig domain containing 4
chr8_-_4275886 0.172 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr17_-_53539411 0.168 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr7_-_101903783 0.166 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr8_+_61487715 0.165 ENSMUST00000034058.6
ENSMUST00000126575.1
Cbr4

carbonyl reductase 4

chr17_-_23771543 0.165 ENSMUST00000086325.5
Flywch1
FLYWCH-type zinc finger 1
chr3_-_37724321 0.161 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr7_-_104315455 0.159 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr7_+_27591513 0.159 ENSMUST00000108344.2
Akt2
thymoma viral proto-oncogene 2
chr9_-_119341390 0.156 ENSMUST00000139870.1
Myd88
myeloid differentiation primary response gene 88
chr19_-_4625612 0.149 ENSMUST00000025823.3
Rce1
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr3_+_157534103 0.145 ENSMUST00000106058.1
Zranb2
zinc finger, RAN-binding domain containing 2
chr1_-_165634451 0.134 ENSMUST00000111435.2
ENSMUST00000068705.7
Mpzl1

myelin protein zero-like 1

chr3_-_158016419 0.132 ENSMUST00000127778.1
Srsf11
serine/arginine-rich splicing factor 11
chr15_-_76206309 0.130 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
Plec


plectin


chr9_-_114564315 0.130 ENSMUST00000111816.2
Trim71
tripartite motif-containing 71
chr11_+_100319880 0.129 ENSMUST00000049385.7
Eif1
eukaryotic translation initiation factor 1
chr12_-_113422730 0.127 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr17_+_35241746 0.126 ENSMUST00000068056.5
ENSMUST00000174757.1
Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr5_-_31154152 0.125 ENSMUST00000114632.1
ENSMUST00000114631.2
ENSMUST00000067186.6
ENSMUST00000137165.1
ENSMUST00000131391.1
ENSMUST00000141823.1
ENSMUST00000154241.1
Mpv17






MpV17 mitochondrial inner membrane protein






chr7_+_123123870 0.124 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr11_+_60353324 0.123 ENSMUST00000070805.6
ENSMUST00000094140.2
ENSMUST00000108723.2
ENSMUST00000108722.4
Lrrc48



leucine rich repeat containing 48



chr9_-_121839460 0.121 ENSMUST00000135986.2
Ccdc13
coiled-coil domain containing 13
chr10_-_128180265 0.115 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_+_98571004 0.109 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr18_+_74216118 0.106 ENSMUST00000025444.6
Cxxc1
CXXC finger 1 (PHD domain)
chr2_-_180824596 0.104 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr13_-_66227573 0.097 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chrX_-_73659724 0.096 ENSMUST00000114473.1
ENSMUST00000002087.7
Pnck

pregnancy upregulated non-ubiquitously expressed CaM kinase

chr16_+_11203375 0.096 ENSMUST00000181526.1
2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr8_+_84831522 0.095 ENSMUST00000036734.5
Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr11_+_58104229 0.092 ENSMUST00000108843.1
ENSMUST00000134896.1
Cnot8

CCR4-NOT transcription complex, subunit 8

chr11_-_100650693 0.089 ENSMUST00000103119.3
Zfp385c
zinc finger protein 385C
chr6_+_17743582 0.087 ENSMUST00000000674.6
ENSMUST00000077080.2
St7

suppression of tumorigenicity 7

chr11_+_115564434 0.080 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr13_-_66851513 0.074 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr16_-_31275277 0.071 ENSMUST00000060188.7
Ppp1r2
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr11_-_87826023 0.070 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr5_-_88527841 0.070 ENSMUST00000087033.3
Igj
immunoglobulin joining chain
chr6_-_8259098 0.069 ENSMUST00000012627.4
Rpa3
replication protein A3
chr7_-_35647127 0.067 ENSMUST00000120714.1
Pdcd5
programmed cell death 5
chr3_-_95133989 0.067 ENSMUST00000172572.2
ENSMUST00000173462.2
Scnm1

sodium channel modifier 1

chr17_-_56717681 0.065 ENSMUST00000164907.1
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chrX_-_7947848 0.064 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
Hdac6


histone deacetylase 6


chr19_-_53589067 0.062 ENSMUST00000095978.3
Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr17_+_55959146 0.061 ENSMUST00000086869.4
Ccdc94
coiled-coil domain containing 94
chr7_+_44590886 0.061 ENSMUST00000107906.3
Kcnc3
potassium voltage gated channel, Shaw-related subfamily, member 3
chr11_-_99230998 0.060 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr11_+_58104138 0.057 ENSMUST00000020822.5
Cnot8
CCR4-NOT transcription complex, subunit 8
chr13_-_56895737 0.057 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr15_-_79742518 0.055 ENSMUST00000089311.4
ENSMUST00000046259.7
Sun2

Sad1 and UNC84 domain containing 2

chr8_+_105373265 0.055 ENSMUST00000160650.1
Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr1_+_171419027 0.053 ENSMUST00000171362.1
Tstd1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr5_+_123907175 0.050 ENSMUST00000023869.8
Denr
density-regulated protein
chr14_+_58893465 0.050 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr8_-_94918012 0.047 ENSMUST00000077955.5
Ccdc102a
coiled-coil domain containing 102A
chr10_+_80603253 0.047 ENSMUST00000180350.1
Scamp4
secretory carrier membrane protein 4
chr3_+_108571699 0.045 ENSMUST00000143054.1
Taf13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr3_+_146220955 0.044 ENSMUST00000039164.2
Lpar3
lysophosphatidic acid receptor 3
chr5_-_100373484 0.044 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr13_-_90089060 0.043 ENSMUST00000161396.1
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr16_-_18876655 0.038 ENSMUST00000023391.8
Mrpl40
mitochondrial ribosomal protein L40
chr9_-_103228420 0.036 ENSMUST00000126359.1
Trf
transferrin
chr5_+_21543525 0.034 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr14_+_29978337 0.034 ENSMUST00000016115.4
Actr8
ARP8 actin-related protein 8
chr2_+_127336152 0.030 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr12_+_8921598 0.024 ENSMUST00000020909.3
Laptm4a
lysosomal-associated protein transmembrane 4A
chr8_-_121829480 0.021 ENSMUST00000174717.1
ENSMUST00000174192.1
ENSMUST00000045884.10
Klhdc4


kelch domain containing 4


chr5_+_90903864 0.021 ENSMUST00000075433.6
Cxcl2
chemokine (C-X-C motif) ligand 2
chr13_+_100124850 0.017 ENSMUST00000022147.8
ENSMUST00000091321.5
ENSMUST00000143937.1
Smn1


survival motor neuron 1


chr5_-_129879038 0.017 ENSMUST00000026617.6
Phkg1
phosphorylase kinase gamma 1
chr10_-_78487842 0.016 ENSMUST00000069431.4
Gm9978
predicted gene 9978
chr11_-_11627824 0.016 ENSMUST00000081896.4
4930512M02Rik
RIKEN cDNA 4930512M02 gene
chrX_-_12673540 0.016 ENSMUST00000060108.6
1810030O07Rik
RIKEN cDNA 1810030O07 gene
chr17_+_56717759 0.015 ENSMUST00000002452.6
Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr7_+_81762925 0.013 ENSMUST00000042166.4
Fam103a1
family with sequence similarity 103, member A1
chr2_+_152293828 0.010 ENSMUST00000028963.7
ENSMUST00000144252.1
Tbc1d20

TBC1 domain family, member 20

chr6_+_128662379 0.010 ENSMUST00000032518.4
Clec2h
C-type lectin domain family 2, member h
chr19_-_55315980 0.008 ENSMUST00000076891.5
Zdhhc6
zinc finger, DHHC domain containing 6
chr11_-_102365111 0.008 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr7_+_30232310 0.006 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr3_+_130068390 0.005 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr9_-_70503718 0.003 ENSMUST00000034739.5
Rnf111
ring finger 111
chr7_-_4778141 0.001 ENSMUST00000094892.5
Il11
interleukin 11
chr6_+_48537560 0.001 ENSMUST00000040361.5
Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.2 1.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 0.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 0.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 0.8 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 1.3 GO:0051923 sulfation(GO:0051923)
0.1 0.3 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 0.4 GO:0060032 notochord regression(GO:0060032)
0.1 0.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.7 GO:0070236 positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.4 GO:0046208 spermine catabolic process(GO:0046208)
0.1 0.4 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 0.2 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.1 0.3 GO:0015074 DNA integration(GO:0015074)
0.1 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.2 GO:2000338 positive regulation of interleukin-23 production(GO:0032747) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.1 0.4 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.4 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.3 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0030647 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0 0.3 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.4 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.4 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.1 GO:0002339 B cell selection(GO:0002339)
0.0 0.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.0 2.3 GO:0009566 fertilization(GO:0009566)
0.0 0.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.3 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.2 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0045954 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.3 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.3 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.3 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.2 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0036449 microtubule minus-end(GO:0036449)
0.2 0.6 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.2 2.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.3 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0001741 XY body(GO:0001741)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.3 2.5 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.3 0.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 0.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 0.5 GO:0019841 retinol binding(GO:0019841)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.2 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.3 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.2 GO:0070976 TIR domain binding(GO:0070976)
0.0 0.4 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.0 0.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.3 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.5 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0001222 transcription corepressor binding(GO:0001222)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 0.5 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters