Motif ID: Smad1

Z-value: 1.369


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.212.1e-01Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 8.754 ENSMUST00000075312.3
 Ttr
transthyretin
chrX_+_73483602 8.254 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr15_-_66812593 6.584 ENSMUST00000100572.3
 Sla
src-like adaptor
chr2_-_25470031 3.970 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr1_-_171234290 3.922 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr2_-_152951547 3.629 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr11_-_55419898 3.579 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr2_-_93452679 3.435 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr12_-_24680890 3.310 ENSMUST00000156453.2
 Cys1
cystin 1
chr19_-_57118981 3.248 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr6_+_55336424 2.784 ENSMUST00000004774.3
 Aqp1
aquaporin 1
chr8_+_104101625 2.633 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr4_-_133498538 2.527 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr7_-_19861299 2.453 ENSMUST00000014830.7
 Ceacam16
carcinoembryonic antigen-related cell adhesion molecule 16
chr5_-_139129662 2.449 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr18_-_66860458 2.420 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr11_+_32296489 2.391 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr11_+_49794157 2.376 ENSMUST00000020629.4
 Gfpt2
glutamine fructose-6-phosphate transaminase 2
chr8_+_104170513 2.339 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
 Bean1



brain expressed, associated with Nedd4, 1



chr10_+_79988584 2.335 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 730 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.8 GO:0030032 lamellipodium assembly(GO:0030032)
2.0 10.0 GO:0070327 thyroid hormone transport(GO:0070327)
1.0 8.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 8.1 GO:0034605 cellular response to heat(GO:0034605)
0.3 5.6 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 5.6 GO:0007416 synapse assembly(GO:0007416)
0.9 5.4 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.0 5.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.6 4.7 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 4.3 GO:0006818 hydrogen transport(GO:0006818)
0.1 4.0 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713)
0.3 3.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 3.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 3.6 GO:0001955 blood vessel maturation(GO:0001955)
0.5 3.6 GO:0015862 uridine transport(GO:0015862)
0.2 3.1 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 3.1 GO:0030279 negative regulation of ossification(GO:0030279)
1.0 3.0 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 2.9 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.1 2.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 286 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.7 GO:0005615 extracellular space(GO:0005615)
0.0 12.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 10.8 GO:0030133 transport vesicle(GO:0030133)
0.1 10.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 8.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 7.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.6 6.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 6.4 GO:0072562 blood microparticle(GO:0072562)
0.0 5.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.8 GO:0009986 cell surface(GO:0009986)
0.0 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.8 5.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 5.3 GO:0031526 brush border membrane(GO:0031526)
0.1 5.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 4.8 GO:0005769 early endosome(GO:0005769)
1.2 4.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 4.5 GO:0000139 Golgi membrane(GO:0000139)
0.3 4.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 4.3 GO:0048786 presynaptic active zone(GO:0048786)
0.1 4.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 453 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 11.2 GO:0003924 GTPase activity(GO:0003924)
0.2 11.1 GO:0050840 extracellular matrix binding(GO:0050840)
1.1 9.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.3 8.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
1.6 6.6 GO:0031720 haptoglobin binding(GO:0031720)
0.1 6.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.1 6.4 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.2 5.2 GO:0051787 misfolded protein binding(GO:0051787)
1.2 4.9 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 4.3 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 4.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 4.2 GO:0005516 calmodulin binding(GO:0005516)
0.3 4.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 3.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 3.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.9 3.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 3.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.1 3.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 10.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 7.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 5.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 5.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 4.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 3.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 3.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 3.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 2.8 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.7 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 2.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 2.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.0 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 12.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.5 12.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 9.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.6 8.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 7.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.5 6.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 4.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 4.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 4.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.4 4.1 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 4.0 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 3.9 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 3.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 3.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 3.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 3.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 3.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 3.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5 2.8 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway