Motif ID: Smad2
Z-value: 0.523
Transcription factors associated with Smad2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Smad2 | ENSMUSG00000024563.9 | Smad2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad2 | mm10_v2_chr18_+_76242135_76242174 | -0.20 | 2.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) |
| 0.3 | 1.3 | GO:0021764 | amygdala development(GO:0021764) |
| 0.2 | 1.4 | GO:1903012 | positive regulation of bone development(GO:1903012) |
| 0.2 | 3.6 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.2 | 0.5 | GO:0070844 | misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846) |
| 0.1 | 0.4 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627) |
| 0.1 | 1.5 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 0.9 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.1 | 0.4 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.1 | 0.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 1.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 0.5 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 2.6 | GO:0007129 | synapsis(GO:0007129) |
| 0.1 | 0.3 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 0.2 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 0.7 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.0 | 3.2 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.0 | 1.3 | GO:0048599 | oocyte development(GO:0048599) |
| 0.0 | 0.3 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 0.0 | 0.5 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.0 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
| 0.0 | 0.6 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.0 | 0.5 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.0 | 0.1 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.0 | 0.3 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.2 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 0.1 | GO:0090148 | membrane fission(GO:0090148) |
| 0.0 | 2.2 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 1.4 | GO:0048469 | cell maturation(GO:0048469) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.2 | 1.1 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 0.3 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.1 | 1.2 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.1 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.3 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.2 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 1.3 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.5 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.2 | 1.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.2 | 1.2 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.2 | 1.5 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 0.5 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 1.3 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 2.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.7 | GO:0001727 | lipid kinase activity(GO:0001727) diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 0.4 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.1 | 1.1 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 1.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.9 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.5 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.3 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.1 | GO:0001156 | TFIIIC-class transcription factor binding(GO:0001156) |
| 0.0 | 1.3 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.0 | 0.0 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.0 | 3.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 2.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.2 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.5 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
