Motif ID: Smad3

Z-value: 0.564


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_63757994-0.251.3e-01Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_53707532 4.867 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr7_+_51880312 1.742 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr18_-_74207771 1.695 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr14_-_62456286 1.663 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr13_-_21832194 1.657 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr13_+_23533869 1.602 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_21750505 1.395 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr5_+_75574916 1.391 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chr13_-_23551648 1.337 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr9_-_66514567 1.267 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr1_+_146497614 1.214 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chrX_-_7188713 1.213 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr6_-_72235559 1.125 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr13_+_23581563 1.123 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_+_23531044 1.060 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr13_-_22042949 1.052 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr17_-_31277327 1.045 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr13_+_21735055 0.987 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr5_+_114774677 0.908 ENSMUST00000102578.4
 Ankrd13a
ankyrin repeat domain 13a
chr13_-_21833575 0.879 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.6 4.9 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.0 4.9 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 1.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 1.7 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.5 1.4 GO:1904347 intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.2 GO:0035082 axoneme assembly(GO:0035082)
0.1 1.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 1.0 GO:0016578 histone deubiquitination(GO:0016578)
0.2 0.6 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738) regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.5 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 0.4 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 4.8 GO:0000786 nucleosome(GO:0000786)
0.0 3.9 GO:0043195 terminal bouton(GO:0043195)
0.1 1.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.0 GO:0070938 contractile ring(GO:0070938)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 GO:0042393 histone binding(GO:0042393)
0.1 4.9 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 3.4 GO:0008017 microtubule binding(GO:0008017)
0.1 1.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 1.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.2 0.6 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 4.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors