Motif ID: Smad3

Z-value: 0.564


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_63757994-0.251.3e-01Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_53707532 4.867 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr7_+_51880312 1.742 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr18_-_74207771 1.695 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr14_-_62456286 1.663 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr13_-_21832194 1.657 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr13_+_23533869 1.602 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_21750505 1.395 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr5_+_75574916 1.391 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chr13_-_23551648 1.337 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr9_-_66514567 1.267 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr1_+_146497614 1.214 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chrX_-_7188713 1.213 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr6_-_72235559 1.125 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr13_+_23581563 1.123 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_+_23531044 1.060 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr13_-_22042949 1.052 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr17_-_31277327 1.045 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr13_+_21735055 0.987 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr5_+_114774677 0.908 ENSMUST00000102578.4
 Ankrd13a
ankyrin repeat domain 13a
chr13_-_21833575 0.879 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr13_+_22043189 0.855 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr13_-_23571151 0.688 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae
chr18_-_77047243 0.679 ENSMUST00000137354.1
ENSMUST00000137498.1
 Katnal2

katanin p60 subunit A-like 2

chr13_+_21810428 0.648 ENSMUST00000091745.5
 Hist1h2ao
histone cluster 1, H2ao
chr1_+_171250416 0.631 ENSMUST00000111315.1
ENSMUST00000006570.5
 Adamts4

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4

chr13_+_92354783 0.625 ENSMUST00000022218.4
 Dhfr
dihydrofolate reductase
chr13_+_21833736 0.592 ENSMUST00000180288.1
ENSMUST00000110467.1
 Hist1h2br

histone cluster 1 H2br

chr9_+_21196705 0.525 ENSMUST00000003395.9
 Pde4a
phosphodiesterase 4A, cAMP specific
chr13_+_23684192 0.513 ENSMUST00000018246.4
 Hist1h2bc
histone cluster 1, H2bc
chr13_+_22035821 0.506 ENSMUST00000110455.2
 Hist1h2bk
histone cluster 1, H2bk
chr19_-_47919269 0.505 ENSMUST00000095998.5
 Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr9_-_66593106 0.471 ENSMUST00000127569.1
 Usp3
ubiquitin specific peptidase 3
chr13_+_23571382 0.470 ENSMUST00000079251.5
 Hist1h2bg
histone cluster 1, H2bg
chr18_-_77047282 0.468 ENSMUST00000154665.1
ENSMUST00000026486.6
ENSMUST00000123650.1
ENSMUST00000126153.1
 Katnal2



katanin p60 subunit A-like 2



chr13_-_21787218 0.457 ENSMUST00000091751.2
 Hist1h2an
histone cluster 1, H2an
chr7_-_45052865 0.403 ENSMUST00000057293.6
 Prr12
proline rich 12
chr7_+_82867327 0.375 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr13_-_21810190 0.363 ENSMUST00000110469.1
ENSMUST00000091749.2
 Hist1h2bq

histone cluster 1, H2bq

chr9_+_109038565 0.352 ENSMUST00000112059.3
ENSMUST00000026737.5
 Shisa5

shisa homolog 5 (Xenopus laevis)

chrX_-_95026671 0.343 ENSMUST00000096367.3
 Spin4
spindlin family, member 4
chr13_-_22035589 0.341 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr13_+_21787461 0.320 ENSMUST00000110473.2
ENSMUST00000102982.1
 Hist1h2bp

histone cluster 1, H2bp

chr11_-_87828289 0.316 ENSMUST00000136446.1
 Lpo
lactoperoxidase
chr14_-_49783327 0.316 ENSMUST00000118129.1
ENSMUST00000036972.6
 3632451O06Rik

RIKEN cDNA 3632451O06 gene

chrX_+_105079761 0.293 ENSMUST00000119477.1
 Pbdc1
polysaccharide biosynthesis domain containing 1
chr3_+_107631322 0.288 ENSMUST00000106703.1
 Gm10961
predicted gene 10961
chr4_+_150281573 0.287 ENSMUST00000105682.2
 Rere
arginine glutamic acid dipeptide (RE) repeats
chr10_+_33905015 0.275 ENSMUST00000169670.1
 Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chr7_+_137437591 0.264 ENSMUST00000064404.6
 Glrx3
glutaredoxin 3
chr4_+_45018583 0.261 ENSMUST00000133157.1
ENSMUST00000029999.8
ENSMUST00000107814.3
 Polr1e


polymerase (RNA) I polypeptide E


chr9_-_66593029 0.252 ENSMUST00000098613.2
 Usp3
ubiquitin specific peptidase 3
chr9_-_66592993 0.232 ENSMUST00000174387.1
 Usp3
ubiquitin specific peptidase 3
chr12_+_100779074 0.226 ENSMUST00000110073.1
ENSMUST00000110070.1
 9030617O03Rik

RIKEN cDNA 9030617O03 gene

chr13_+_23746734 0.224 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr10_+_79854658 0.220 ENSMUST00000171599.1
ENSMUST00000095457.4
 Ptbp1

polypyrimidine tract binding protein 1

chr12_+_12911986 0.218 ENSMUST00000085720.1
 Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr14_+_20348159 0.190 ENSMUST00000090503.4
ENSMUST00000090499.5
ENSMUST00000037698.5
ENSMUST00000051915.6
 Fam149b



family with sequence similarity 149, member B



chr2_-_152831665 0.187 ENSMUST00000156688.1
ENSMUST00000007803.5
 Bcl2l1

BCL2-like 1

chr10_-_119240006 0.185 ENSMUST00000020315.6
 Cand1
cullin associated and neddylation disassociated 1
chr2_+_178193075 0.184 ENSMUST00000103065.1
 Phactr3
phosphatase and actin regulator 3
chr6_+_136808248 0.182 ENSMUST00000074556.4
 H2afj
H2A histone family, member J
chr9_-_45936049 0.175 ENSMUST00000034590.2
 Tagln
transgelin
chr10_+_79854618 0.172 ENSMUST00000165704.1
 Ptbp1
polypyrimidine tract binding protein 1
chr1_-_143702832 0.170 ENSMUST00000018337.7
 Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
chr7_-_44236098 0.164 ENSMUST00000037220.4
 1700028J19Rik
RIKEN cDNA 1700028J19 gene
chrX_+_153832225 0.149 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
 Spin2c


spindlin family, member 2C


chr1_+_75210832 0.141 ENSMUST00000027401.4
ENSMUST00000144355.1
ENSMUST00000123825.1
 Stk16


serine/threonine kinase 16


chr9_+_13621646 0.118 ENSMUST00000034401.8
 Maml2
mastermind like 2 (Drosophila)
chr4_+_151089570 0.116 ENSMUST00000105667.2
 Gm13090
predicted gene 13090
chr7_-_100964371 0.110 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr15_+_81936911 0.096 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr13_-_23683941 0.093 ENSMUST00000171127.1
 Hist1h2ac
histone cluster 1, H2ac
chr3_+_102734496 0.068 ENSMUST00000029451.5
 Tspan2
tetraspanin 2
chr7_+_25221417 0.065 ENSMUST00000055604.4
 Zfp526
zinc finger protein 526
chr4_+_95557494 0.064 ENSMUST00000079223.4
ENSMUST00000177394.1
 Fggy

FGGY carbohydrate kinase domain containing

chr15_-_58823530 0.063 ENSMUST00000072113.5
 Tmem65
transmembrane protein 65
chr9_-_60688118 0.053 ENSMUST00000114034.2
ENSMUST00000065603.5
 Lrrc49

leucine rich repeat containing 49

chr11_-_103344651 0.049 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chrX_+_143664290 0.045 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr16_-_15594507 0.028 ENSMUST00000115776.1
ENSMUST00000115777.3
 Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr2_+_129065934 0.013 ENSMUST00000035812.7
 Ttl
tubulin tyrosine ligase
chr11_+_46436925 0.010 ENSMUST00000152119.1
ENSMUST00000140027.1
ENSMUST00000020665.6
ENSMUST00000170928.1
ENSMUST00000109231.1
ENSMUST00000109232.3
ENSMUST00000128940.1
 Med7






mediator complex subunit 7






chr9_+_108490676 0.004 ENSMUST00000178075.1
ENSMUST00000085044.7
ENSMUST00000166103.2
ENSMUST00000006854.7
 Usp19



ubiquitin specific peptidase 19



chr18_+_31634374 0.000 ENSMUST00000025109.7
 Sap130
Sin3A associated protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.5 1.4 GO:1904347 intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)
0.4 7.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 0.6 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
0.1 1.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.3 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.3 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.1 1.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.4 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 1.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 4.9 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 1.0 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.1 GO:0046898 response to cycloheximide(GO:0046898)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.1 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738) regulation of cAMP-mediated signaling(GO:0043949)
0.0 1.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.5 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.0 1.7 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 4.8 GO:0000786 nucleosome(GO:0000786)
0.1 1.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.0 GO:0070938 contractile ring(GO:0070938)
0.0 3.9 GO:0043195 terminal bouton(GO:0043195)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.3 GO:0030018 Z disc(GO:0030018)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0051870 methotrexate binding(GO:0051870)
0.2 1.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 4.9 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 1.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 8.5 GO:0042393 histone binding(GO:0042393)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 3.4 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors