Motif ID: Smad4

Z-value: 1.049


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.529.2e-04Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_127534540 10.655 ENSMUST00000095266.2
Nxph4
neurexophilin 4
chr19_+_5740885 6.203 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr4_-_117178726 5.537 ENSMUST00000153953.1
ENSMUST00000106436.1
Kif2c

kinesin family member 2C

chr7_-_70360593 5.308 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_+_45216671 5.176 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr7_+_45215753 4.921 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
Tead2


TEA domain family member 2


chr18_-_84086379 4.482 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr10_-_92164666 4.382 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr10_-_42583628 4.179 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr14_+_50944499 4.111 ENSMUST00000178092.1
Pnp
purine-nucleoside phosphorylase
chr3_+_127633134 4.107 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr5_+_92683625 3.781 ENSMUST00000168878.1
Shroom3
shroom family member 3
chr14_-_104467984 3.579 ENSMUST00000053016.8
Pou4f1
POU domain, class 4, transcription factor 1
chr1_+_153652943 3.186 ENSMUST00000041776.5
Rgs8
regulator of G-protein signaling 8
chr17_+_75178797 3.071 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr14_+_12189943 3.038 ENSMUST00000119888.1
Ptprg
protein tyrosine phosphatase, receptor type, G
chr11_-_5261558 2.829 ENSMUST00000020662.8
Kremen1
kringle containing transmembrane protein 1
chr17_+_75178911 2.814 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr4_+_97772734 2.711 ENSMUST00000152023.1
Nfia
nuclear factor I/A
chr8_+_45658273 2.664 ENSMUST00000153798.1
Sorbs2
sorbin and SH3 domain containing 2
chr17_+_72918298 2.657 ENSMUST00000024857.6
Lbh
limb-bud and heart
chr13_-_21832194 2.634 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr17_-_70851710 2.587 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr11_-_3931960 2.550 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
Tcn2




transcobalamin 2




chr5_+_64803513 2.537 ENSMUST00000165536.1
Klf3
Kruppel-like factor 3 (basic)
chr18_+_5593566 2.463 ENSMUST00000160910.1
Zeb1
zinc finger E-box binding homeobox 1
chr14_-_54577578 2.403 ENSMUST00000054487.8
Ajuba
ajuba LIM protein
chr16_-_55283237 2.246 ENSMUST00000036412.3
Zpld1
zona pellucida like domain containing 1
chr11_-_3931789 2.177 ENSMUST00000109992.1
ENSMUST00000109988.1
Tcn2

transcobalamin 2

chr11_+_60699758 2.156 ENSMUST00000108719.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr5_-_124352233 2.056 ENSMUST00000111472.1
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr11_+_60699718 2.042 ENSMUST00000052346.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr18_+_57133065 1.990 ENSMUST00000075770.6
Megf10
multiple EGF-like-domains 10
chr5_+_75574916 1.981 ENSMUST00000144270.1
ENSMUST00000005815.6
Kit

kit oncogene

chr2_+_27676440 1.967 ENSMUST00000129514.1
Rxra
retinoid X receptor alpha
chr14_-_57826128 1.964 ENSMUST00000022536.2
Ska3
spindle and kinetochore associated complex subunit 3
chr15_+_39076885 1.859 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr5_+_120431770 1.851 ENSMUST00000031591.7
Lhx5
LIM homeobox protein 5
chr13_+_21735055 1.836 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr13_-_98890974 1.832 ENSMUST00000179301.1
ENSMUST00000179271.1
Tnpo1

transportin 1

chr19_-_40271506 1.800 ENSMUST00000068439.6
Pdlim1
PDZ and LIM domain 1 (elfin)
chr17_+_34597852 1.781 ENSMUST00000174496.2
ENSMUST00000015596.3
ENSMUST00000173992.1
Ager


advanced glycosylation end product-specific receptor


chr6_+_38433913 1.772 ENSMUST00000160583.1
Ubn2
ubinuclein 2
chrX_+_99136119 1.739 ENSMUST00000052839.6
Efnb1
ephrin B1
chr13_+_23581563 1.730 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr14_+_54640952 1.646 ENSMUST00000169818.2
Gm17606
predicted gene, 17606
chr13_-_98891036 1.645 ENSMUST00000109399.2
Tnpo1
transportin 1
chr11_-_69413675 1.562 ENSMUST00000094077.4
Kdm6b
KDM1 lysine (K)-specific demethylase 6B
chr7_+_110221697 1.526 ENSMUST00000033325.7
Swap70
SWA-70 protein
chr2_+_119547697 1.491 ENSMUST00000014221.6
ENSMUST00000119172.1
Chp1

calcineurin-like EF hand protein 1

chr10_+_80150448 1.477 ENSMUST00000153477.1
Midn
midnolin
chr9_+_13621646 1.448 ENSMUST00000034401.8
Maml2
mastermind like 2 (Drosophila)
chr4_+_128688726 1.446 ENSMUST00000106080.1
Phc2
polyhomeotic-like 2 (Drosophila)
chr3_+_88607742 1.430 ENSMUST00000175903.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr9_-_105521147 1.419 ENSMUST00000176770.1
ENSMUST00000085133.6
Atp2c1

ATPase, Ca++-sequestering

chr9_-_45936049 1.365 ENSMUST00000034590.2
Tagln
transgelin
chr7_+_82867327 1.330 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr14_-_20496780 1.319 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr13_-_23551648 1.286 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr4_+_116221689 1.248 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr13_-_22042949 1.217 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr1_+_187997835 1.216 ENSMUST00000110938.1
Esrrg
estrogen-related receptor gamma
chr10_+_127739516 1.190 ENSMUST00000054287.7
Zbtb39
zinc finger and BTB domain containing 39
chr4_+_116221633 1.185 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_-_143702832 1.171 ENSMUST00000018337.7
Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
chr11_+_60104971 1.162 ENSMUST00000064190.6
Rai1
retinoic acid induced 1
chr1_+_187997821 1.161 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma
chr9_-_21852603 1.153 ENSMUST00000034728.7
Dock6
dedicator of cytokinesis 6
chr3_+_107101551 1.135 ENSMUST00000038695.1
Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr5_+_30913398 1.087 ENSMUST00000031055.5
Emilin1
elastin microfibril interfacer 1
chr3_-_33143227 1.086 ENSMUST00000108219.1
Pex5l
peroxisomal biogenesis factor 5-like
chr8_-_34146974 1.080 ENSMUST00000033910.8
Leprotl1
leptin receptor overlapping transcript-like 1
chr12_+_13269111 1.055 ENSMUST00000042953.8
Nbas
neuroblastoma amplified sequence
chr13_+_23531044 1.021 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr4_+_116221590 1.009 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chrX_-_72274747 1.008 ENSMUST00000064780.3
Gabre
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr13_+_22043189 0.967 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr6_-_83775767 0.963 ENSMUST00000014892.6
Tex261
testis expressed gene 261
chr14_-_64949632 0.951 ENSMUST00000176832.1
Hmbox1
homeobox containing 1
chr7_-_45870928 0.934 ENSMUST00000146672.1
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr14_-_64949838 0.931 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
Hmbox1





homeobox containing 1





chr7_-_45052865 0.915 ENSMUST00000057293.6
Prr12
proline rich 12
chr2_+_69670100 0.915 ENSMUST00000100050.3
Klhl41
kelch-like 41
chr7_+_101421691 0.884 ENSMUST00000163751.2
ENSMUST00000084894.7
ENSMUST00000166652.1
Pde2a


phosphodiesterase 2A, cGMP-stimulated


chr3_-_96220880 0.882 ENSMUST00000090782.3
Hist2h2ac
histone cluster 2, H2ac
chr10_+_75589363 0.880 ENSMUST00000072217.2
Ggt5
gamma-glutamyltransferase 5
chr8_-_41016749 0.861 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr7_+_127485221 0.839 ENSMUST00000048896.6
Fbrs
fibrosin
chr7_+_141949846 0.829 ENSMUST00000172652.1
Brsk2
BR serine/threonine kinase 2
chr7_-_27181149 0.824 ENSMUST00000071986.6
ENSMUST00000121848.1
Mia

melanoma inhibitory activity

chr16_+_43235856 0.822 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr3_+_89436699 0.795 ENSMUST00000038942.3
ENSMUST00000130858.1
Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr7_+_141216626 0.765 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr16_+_43247278 0.762 ENSMUST00000114691.1
ENSMUST00000079441.6
Zbtb20

zinc finger and BTB domain containing 20

chr14_+_64950037 0.757 ENSMUST00000043914.5
Ints9
integrator complex subunit 9
chr1_-_45503282 0.752 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr8_-_47352348 0.738 ENSMUST00000110367.2
Stox2
storkhead box 2
chr15_-_96460838 0.736 ENSMUST00000047835.6
Scaf11
SR-related CTD-associated factor 11
chr4_+_148130883 0.732 ENSMUST00000084129.2
Mad2l2
MAD2 mitotic arrest deficient-like 2
chr7_+_141949982 0.718 ENSMUST00000105989.2
ENSMUST00000075528.5
ENSMUST00000174499.1
Brsk2


BR serine/threonine kinase 2


chr6_+_54039935 0.679 ENSMUST00000114403.1
Chn2
chimerin (chimaerin) 2
chr7_-_119895697 0.668 ENSMUST00000059851.6
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr12_+_76404168 0.667 ENSMUST00000080449.5
Hspa2
heat shock protein 2
chr11_-_106160708 0.624 ENSMUST00000106875.1
Limd2
LIM domain containing 2
chr9_+_122888471 0.623 ENSMUST00000063980.6
Zkscan7
zinc finger with KRAB and SCAN domains 7
chr9_-_57552760 0.622 ENSMUST00000034856.8
Mpi
mannose phosphate isomerase
chr10_+_18845071 0.610 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr17_-_35162969 0.601 ENSMUST00000174805.1
Prrc2a
proline-rich coiled-coil 2A
chr8_-_92356103 0.551 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr6_+_147032528 0.541 ENSMUST00000036194.4
Rep15
RAB15 effector protein
chr1_-_16770138 0.514 ENSMUST00000071842.8
Gm5828
predicted gene 5828
chr2_+_120476911 0.505 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr6_+_54039558 0.504 ENSMUST00000046856.7
Chn2
chimerin (chimaerin) 2
chr6_+_15720654 0.496 ENSMUST00000101663.3
Mdfic
MyoD family inhibitor domain containing
chr10_+_33905015 0.491 ENSMUST00000169670.1
Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chr1_-_74588117 0.489 ENSMUST00000066986.6
Zfp142
zinc finger protein 142
chr7_+_101394361 0.488 ENSMUST00000154239.1
ENSMUST00000098243.2
Arap1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr11_-_4160286 0.479 ENSMUST00000093381.4
ENSMUST00000101626.2
Ccdc157

coiled-coil domain containing 157

chr3_+_89436736 0.477 ENSMUST00000146630.1
ENSMUST00000145753.1
Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr9_+_21424984 0.476 ENSMUST00000172482.1
ENSMUST00000174050.1
Dnm2

dynamin 2

chr6_+_54040078 0.474 ENSMUST00000127323.2
Chn2
chimerin (chimaerin) 2
chr3_+_96221111 0.474 ENSMUST00000090781.6
Hist2h2be
histone cluster 2, H2be
chr14_-_54554359 0.453 ENSMUST00000022784.8
Haus4
HAUS augmin-like complex, subunit 4
chr9_-_20898592 0.449 ENSMUST00000004206.8
Eif3g
eukaryotic translation initiation factor 3, subunit G
chr3_-_146839365 0.438 ENSMUST00000084614.3
Gm10288
predicted gene 10288
chrX_+_136270253 0.423 ENSMUST00000178632.1
ENSMUST00000053540.4
Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr11_-_106160101 0.421 ENSMUST00000045923.3
Limd2
LIM domain containing 2
chr7_+_83755904 0.419 ENSMUST00000051522.8
ENSMUST00000042280.7
Gm7964

predicted gene 7964

chr10_+_91083036 0.417 ENSMUST00000020149.5
Ikbip
IKBKB interacting protein
chrX_+_151803642 0.415 ENSMUST00000156616.2
Huwe1
HECT, UBA and WWE domain containing 1
chr16_+_34784917 0.407 ENSMUST00000023538.8
Mylk
myosin, light polypeptide kinase
chrX_+_136270302 0.398 ENSMUST00000113112.1
Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr4_+_130055010 0.385 ENSMUST00000123617.1
Col16a1
collagen, type XVI, alpha 1
chr11_+_4160348 0.384 ENSMUST00000002198.3
Sf3a1
splicing factor 3a, subunit 1
chr5_+_121795034 0.382 ENSMUST00000162327.1
Atxn2
ataxin 2
chr3_-_116968827 0.375 ENSMUST00000119557.1
Palmd
palmdelphin
chr4_-_148500449 0.369 ENSMUST00000030840.3
Angptl7
angiopoietin-like 7
chr4_+_133011506 0.353 ENSMUST00000105915.1
ENSMUST00000105916.1
Ahdc1

AT hook, DNA binding motif, containing 1

chr2_+_27079371 0.339 ENSMUST00000091233.6
Adamtsl2
ADAMTS-like 2
chr18_-_35498856 0.329 ENSMUST00000025215.8
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr10_-_91082653 0.320 ENSMUST00000159110.1
Apaf1
apoptotic peptidase activating factor 1
chr9_+_106429537 0.309 ENSMUST00000059802.6
Rpl29
ribosomal protein L29
chr10_-_91082704 0.290 ENSMUST00000162618.1
ENSMUST00000020157.6
ENSMUST00000160788.1
Apaf1


apoptotic peptidase activating factor 1


chrX_-_150588071 0.283 ENSMUST00000140207.1
ENSMUST00000112719.1
ENSMUST00000112727.3
ENSMUST00000112721.3
ENSMUST00000026303.9
Apex2




apurinic/apyrimidinic endonuclease 2




chr15_-_98607611 0.275 ENSMUST00000096224.4
Adcy6
adenylate cyclase 6
chr4_+_126677630 0.252 ENSMUST00000030642.2
Psmb2
proteasome (prosome, macropain) subunit, beta type 2
chr2_-_29869785 0.249 ENSMUST00000047607.1
2600006K01Rik
RIKEN cDNA 2600006K01 gene
chr10_+_91082940 0.239 ENSMUST00000020150.3
Ikbip
IKBKB interacting protein
chrX_+_18162575 0.230 ENSMUST00000044484.6
ENSMUST00000052368.8
Kdm6a

lysine (K)-specific demethylase 6A

chr5_-_24445166 0.224 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr13_-_115090123 0.209 ENSMUST00000109226.3
Pelo
pelota homolog (Drosophila)
chr2_+_69897220 0.199 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr7_-_4778141 0.199 ENSMUST00000094892.5
Il11
interleukin 11
chr5_+_7179299 0.189 ENSMUST00000179460.1
Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr5_-_24445254 0.185 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr11_+_4637734 0.180 ENSMUST00000109930.2
ENSMUST00000070257.7
Ascc2

activating signal cointegrator 1 complex subunit 2

chr2_-_128967725 0.176 ENSMUST00000099385.2
Gm10762
predicted gene 10762
chr17_+_34145231 0.146 ENSMUST00000171231.1
H2-DMb2
histocompatibility 2, class II, locus Mb2
chr5_+_32611171 0.134 ENSMUST00000072311.6
ENSMUST00000168707.2
Yes1

Yamaguchi sarcoma viral (v-yes) oncogene homolog 1

chr19_+_46328179 0.127 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15

F-box and leucine-rich repeat protein 15

chr4_-_129742275 0.125 ENSMUST00000066257.5
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
chr3_-_116968969 0.121 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr7_+_4690760 0.108 ENSMUST00000048248.7
Brsk1
BR serine/threonine kinase 1
chr13_-_41847626 0.100 ENSMUST00000121404.1
Adtrp
androgen dependent TFPI regulating protein
chr5_-_24601961 0.087 ENSMUST00000030791.7
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr17_+_46646225 0.072 ENSMUST00000002844.7
ENSMUST00000113429.1
ENSMUST00000113430.1
Mrpl2


mitochondrial ribosomal protein L2


chr18_-_38918642 0.063 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr11_-_102319093 0.048 ENSMUST00000174302.1
ENSMUST00000178839.1
ENSMUST00000006754.7
Ubtf


upstream binding transcription factor, RNA polymerase I


chr11_-_115419917 0.039 ENSMUST00000106537.1
ENSMUST00000043931.2
ENSMUST00000073791.3
Atp5h


ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d


chr4_-_119190005 0.038 ENSMUST00000138395.1
ENSMUST00000156746.1
Ermap

erythroblast membrane-associated protein

chr6_-_72958465 0.035 ENSMUST00000114050.1
Tmsb10
thymosin, beta 10
chr2_+_152226839 0.033 ENSMUST00000099224.3
ENSMUST00000124791.1
ENSMUST00000133119.1
Csnk2a1


casein kinase 2, alpha 1 polypeptide


chr19_+_4097392 0.032 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr17_+_24352037 0.030 ENSMUST00000079594.5
Abca3
ATP-binding cassette, sub-family A (ABC1), member 3
chr3_+_36552600 0.026 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9

exosome component 9

chr13_-_23934156 0.025 ENSMUST00000052776.2
Hist1h2ba
histone cluster 1, H2ba
chr17_+_34263209 0.013 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr1_+_72583245 0.012 ENSMUST00000145868.1
ENSMUST00000133123.1
ENSMUST00000047615.8
Smarcal1


SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1


chr11_-_106159902 0.007 ENSMUST00000064545.4
Limd2
LIM domain containing 2
chr12_+_36381519 0.002 ENSMUST00000062041.5
Ispd
isoprenoid synthase domain containing
chrX_-_38564519 0.002 ENSMUST00000016681.8
Cul4b
cullin 4B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.5 4.5 GO:0060023 soft palate development(GO:0060023)
1.4 4.1 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
1.2 4.7 GO:0015889 cobalamin transport(GO:0015889)
1.1 5.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.1 5.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.8 4.2 GO:0021764 amygdala development(GO:0021764)
0.7 3.6 GO:0019230 proprioception(GO:0019230)
0.7 2.0 GO:1904347 intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)
0.6 1.8 GO:1905203 regulation of connective tissue replacement(GO:1905203)
0.5 2.7 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.4 8.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.4 10.1 GO:0048368 lateral mesoderm development(GO:0048368)
0.4 2.5 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.4 2.0 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.4 1.5 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.4 1.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.3 2.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.3 3.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 1.9 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.3 1.5 GO:1902309 regulation of cell-cell adhesion mediated by integrin(GO:0033632) negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.3 0.9 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.3 4.2 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.3 2.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 0.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 1.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 3.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 0.7 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 5.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 1.1 GO:0021631 optic nerve morphogenesis(GO:0021631) regulation of circadian sleep/wake cycle, non-REM sleep(GO:0045188)
0.2 2.7 GO:0072189 ureter development(GO:0072189)
0.2 1.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 0.7 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.2 0.9 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 0.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.2 0.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 2.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 1.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.2 1.1 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 1.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 0.5 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity(GO:1903406)
0.2 1.9 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.2 1.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 1.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 1.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 0.6 GO:0002934 desmosome organization(GO:0002934)
0.1 3.4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 1.7 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 0.4 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.1 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.1 1.2 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.1 0.9 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.1 0.6 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 3.0 GO:1901998 toxin transport(GO:1901998)
0.1 3.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 2.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.9 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 1.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.5 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.5 GO:0033572 transferrin transport(GO:0033572)
0.0 0.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.7 GO:0010225 response to UV-C(GO:0010225)
0.0 1.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.9 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 4.1 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.8 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.0 0.3 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 2.1 GO:0006342 chromatin silencing(GO:0006342)
0.0 2.1 GO:0001701 in utero embryonic development(GO:0001701)
0.0 1.1 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 0.1 GO:0036120 response to platelet-derived growth factor(GO:0036119) cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 0.4 GO:0033622 integrin activation(GO:0033622)
0.0 2.7 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 1.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.6 GO:0006284 base-excision repair(GO:0006284)
0.0 0.2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.5 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.0 GO:0071674 mononuclear cell migration(GO:0071674)
0.0 0.3 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.7 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 0.5 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.5 GO:0007257 activation of JUN kinase activity(GO:0007257)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.0 5.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 4.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 1.1 GO:0070939 Dsl1p complex(GO:0070939)
0.3 0.9 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.3 1.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 0.8 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.7 GO:0036128 CatSper complex(GO:0036128)
0.2 5.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 0.6 GO:0043293 apoptosome(GO:0043293)
0.2 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 3.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 4.2 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 4.0 GO:0000786 nucleosome(GO:0000786)
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.9 GO:0031143 pseudopodium(GO:0031143)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.0 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 1.0 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 1.4 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 6.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.9 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.1 GO:0005874 microtubule(GO:0005874)
0.0 2.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.0 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.2 GO:0050436 microfibril binding(GO:0050436)
1.4 4.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.7 4.7 GO:0031419 cobalamin binding(GO:0031419)
0.6 7.3 GO:0001972 retinoic acid binding(GO:0001972)
0.5 10.1 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.5 3.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4 1.4 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.3 0.9 GO:0036004 GAF domain binding(GO:0036004)
0.3 2.0 GO:0001849 complement component C1q binding(GO:0001849)
0.3 6.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.3 1.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 4.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 2.0 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 1.1 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.2 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.9 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2 2.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 2.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.8 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 3.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 1.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 3.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.3 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 0.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 1.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.7 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 4.0 GO:0070888 E-box binding(GO:0070888)
0.1 3.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 3.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 4.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 0.5 GO:0031432 titin binding(GO:0031432)
0.1 0.5 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 1.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 1.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.7 GO:0051861 glycolipid binding(GO:0051861)
0.0 0.5 GO:0030957 Tat protein binding(GO:0030957)
0.0 8.5 GO:0042393 histone binding(GO:0042393)
0.0 6.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 5.1 GO:0051015 actin filament binding(GO:0051015)
0.0 3.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.2 GO:0035326 enhancer binding(GO:0035326)
0.0 0.1 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 7.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 14.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 1.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 3.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 2.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.1 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 2.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 12.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 4.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.3 3.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 8.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 5.5 REACTOME_KINESINS Genes involved in Kinesins
0.2 3.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 1.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 6.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.1 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 5.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 2.3 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 1.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.9 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction