Motif ID: Smad4

Z-value: 1.049


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.529.2e-04Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 181 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_127534540 10.655 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr19_+_5740885 6.203 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr4_-_117178726 5.537 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr7_-_70360593 5.308 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_+_45216671 5.176 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_+_45215753 4.921 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
 Tead2


TEA domain family member 2


chr18_-_84086379 4.482 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr10_-_92164666 4.382 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr10_-_42583628 4.179 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr14_+_50944499 4.111 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr3_+_127633134 4.107 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr5_+_92683625 3.781 ENSMUST00000168878.1
 Shroom3
shroom family member 3
chr14_-_104467984 3.579 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1
chr1_+_153652943 3.186 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr17_+_75178797 3.071 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr14_+_12189943 3.038 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr11_-_5261558 2.829 ENSMUST00000020662.8
 Kremen1
kringle containing transmembrane protein 1
chr17_+_75178911 2.814 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr4_+_97772734 2.711 ENSMUST00000152023.1
 Nfia
nuclear factor I/A
chr8_+_45658273 2.664 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.1 GO:0048368 lateral mesoderm development(GO:0048368)
0.4 8.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
2.1 6.2 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 5.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
1.1 5.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.1 5.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
1.2 4.7 GO:0015889 cobalamin transport(GO:0015889)
1.5 4.5 GO:0060023 soft palate development(GO:0060023)
0.8 4.2 GO:0021764 amygdala development(GO:0021764)
0.3 4.2 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
1.4 4.1 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.0 4.1 GO:0021954 central nervous system neuron development(GO:0021954)
0.1 3.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.7 3.6 GO:0019230 proprioception(GO:0019230)
0.3 3.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 3.4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2 3.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 3.0 GO:1901998 toxin transport(GO:1901998)
0.5 2.7 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.2 2.7 GO:0072189 ureter development(GO:0072189)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 10.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 6.2 GO:0000790 nuclear chromatin(GO:0000790)
2.0 5.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 5.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 5.1 GO:0005874 microtubule(GO:0005874)
0.1 4.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.4 4.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 4.2 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.0 GO:0000786 nucleosome(GO:0000786)
0.1 3.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.0 2.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.9 GO:0034399 nuclear periphery(GO:0034399)
0.1 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.4 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.1 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 8.5 GO:0042393 histone binding(GO:0042393)
0.6 7.3 GO:0001972 retinoic acid binding(GO:0001972)
1.6 6.2 GO:0050436 microfibril binding(GO:0050436)
0.3 6.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 6.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.1 GO:0051015 actin filament binding(GO:0051015)
0.7 4.7 GO:0031419 cobalamin binding(GO:0031419)
0.2 4.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 4.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
1.4 4.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 4.0 GO:0070888 E-box binding(GO:0070888)
0.1 3.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 3.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.5 3.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 3.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 3.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 2.4 GO:0045294 alpha-catenin binding(GO:0045294)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 4.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 3.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 2.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 2.1 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 2.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 2.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 8.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 6.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 5.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 5.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4 4.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 3.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 3.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.3 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.1 2.1 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII