Motif ID: Smarcc1_Fosl1

Z-value: 1.219

Transcription factors associated with Smarcc1_Fosl1:

Gene SymbolEntrez IDGene Name
Fosl1 ENSMUSG00000024912.5 Fosl1
Smarcc1 ENSMUSG00000032481.10 Smarcc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl1mm10_v2_chr19_+_5447692_54477110.733.4e-07Click!
Smarcc1mm10_v2_chr9_+_110132015_110132102-0.669.0e-06Click!


Activity profile for motif Smarcc1_Fosl1.

activity profile for motif Smarcc1_Fosl1


Sorted Z-values histogram for motif Smarcc1_Fosl1

Sorted Z-values for motif Smarcc1_Fosl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smarcc1_Fosl1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 10.087 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr9_-_20728219 5.788 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr15_-_66812593 5.766 ENSMUST00000100572.3
 Sla
src-like adaptor
chr2_+_156475803 5.327 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_156475844 5.185 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr6_+_17463927 4.727 ENSMUST00000115442.1
 Met
met proto-oncogene
chr10_-_64090241 4.684 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_-_113663670 4.534 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr15_+_38933142 4.513 ENSMUST00000163313.1
 Baalc
brain and acute leukemia, cytoplasmic
chr9_-_86695897 4.452 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr18_-_66860458 4.436 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr9_-_112187766 4.428 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr6_-_124769548 4.424 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr10_+_86779000 4.377 ENSMUST00000099396.2
 Nt5dc3
5'-nucleotidase domain containing 3
chr9_+_60712989 4.369 ENSMUST00000038407.5
 Larp6
La ribonucleoprotein domain family, member 6
chr14_+_65968483 4.278 ENSMUST00000022616.6
 Clu
clusterin
chr2_-_151632471 4.237 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr19_-_59076069 4.139 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr16_+_17144600 4.131 ENSMUST00000115702.1
 Ydjc
YdjC homolog (bacterial)
chr13_-_54611274 4.015 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 456 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 15.7 GO:0034605 cellular response to heat(GO:0034605)
1.7 10.4 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 9.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.9 7.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 7.7 GO:0006906 vesicle fusion(GO:0006906)
1.0 7.0 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.6 6.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 6.3 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.5 6.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 5.8 GO:0048821 erythrocyte development(GO:0048821)
0.1 5.7 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
1.1 5.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 4.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
1.2 4.7 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.9 4.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 4.5 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.8 4.2 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.8 4.2 GO:0002024 diet induced thermogenesis(GO:0002024)
1.0 4.0 GO:0035793 cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.7 3.9 GO:0071955 recycling endosome to Golgi transport(GO:0071955)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 216 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.1 GO:0097060 synaptic membrane(GO:0097060)
0.2 11.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.5 10.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 10.2 GO:0009986 cell surface(GO:0009986)
0.1 9.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 9.2 GO:0042734 presynaptic membrane(GO:0042734)
0.2 8.7 GO:0005581 collagen trimer(GO:0005581)
0.1 8.6 GO:0005604 basement membrane(GO:0005604)
0.7 8.0 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 6.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 6.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 5.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 5.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 5.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 5.3 GO:0032279 asymmetric synapse(GO:0032279)
0.2 4.8 GO:0071565 nBAF complex(GO:0071565)
0.7 4.7 GO:0005638 lamin filament(GO:0005638)
0.0 4.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 4.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 4.4 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 302 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.3 9.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 8.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 8.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.7 7.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 7.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
1.7 7.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 6.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 6.2 GO:0070412 R-SMAD binding(GO:0070412)
0.2 6.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.8 6.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 5.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.2 5.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 5.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 5.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 4.9 GO:0017075 syntaxin-1 binding(GO:0017075)
1.5 4.5 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
1.5 4.4 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 4.4 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 10.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 9.3 PID_ARF_3PATHWAY Arf1 pathway
0.2 9.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 8.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 8.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 7.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 6.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.6 6.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.2 5.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 5.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 4.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 4.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 3.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 2.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 2.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.6 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.5 8.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 8.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 7.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 7.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 6.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 6.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 5.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 5.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 4.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 4.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.5 4.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 4.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 4.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 4.1 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.1 3.9 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 3.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.8 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 3.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation