Motif ID: Snai1_Zeb1_Snai2

Z-value: 2.078

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.741.4e-07Click!
Snai1mm10_v2_chr2_+_167538192_1675382100.212.1e-01Click!
Snai2mm10_v2_chr16_+_14705832_147058580.115.1e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_67922136 25.218 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr12_+_82616885 18.559 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr6_+_114131229 18.498 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr15_-_66831625 15.993 ENSMUST00000164163.1
 Sla
src-like adaptor
chr8_+_70493156 12.780 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr17_-_26201363 11.401 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr19_-_57314896 10.879 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr4_+_85205417 10.207 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr18_-_61911783 10.127 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr15_+_54571358 10.110 ENSMUST00000025356.2
 Mal2
mal, T cell differentiation protein 2
chr13_+_83504032 9.841 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_-_134234492 9.721 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr10_+_81257277 9.474 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr13_-_57907587 9.163 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr6_-_148444336 9.163 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr7_-_4789541 9.023 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr3_-_82074639 8.746 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr4_+_104367549 8.740 ENSMUST00000106830.2
 Dab1
disabled 1
chr2_-_32312162 8.604 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr12_-_4592927 8.584 ENSMUST00000170816.1
 Gm3625
predicted gene 3625

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 946 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 28.3 GO:0034605 cellular response to heat(GO:0034605)
3.2 19.0 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 18.3 GO:0016579 protein deubiquitination(GO:0016579)
0.4 17.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
2.5 17.2 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
2.2 15.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
5.2 15.5 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
2.9 14.6 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.7 14.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.7 14.3 GO:0006491 N-glycan processing(GO:0006491)
0.2 14.1 GO:0030032 lamellipodium assembly(GO:0030032)
2.2 12.9 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.1 12.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.9 12.7 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
3.9 11.7 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
1.3 11.7 GO:0071420 cellular response to histamine(GO:0071420)
1.7 11.6 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
2.9 11.5 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.5 11.3 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
3.7 11.2 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 330 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 49.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 41.8 GO:0097060 synaptic membrane(GO:0097060)
0.6 38.8 GO:0005581 collagen trimer(GO:0005581)
0.3 27.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 27.2 GO:0005604 basement membrane(GO:0005604)
0.3 25.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.3 24.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 19.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
6.3 18.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.9 18.0 GO:0032279 asymmetric synapse(GO:0032279)
3.0 17.9 GO:0008091 spectrin(GO:0008091)
0.3 17.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 15.7 GO:0031225 anchored component of membrane(GO:0031225)
0.3 14.2 GO:0042734 presynaptic membrane(GO:0042734)
1.1 14.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.1 14.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.9 13.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.9 13.8 GO:0043196 varicosity(GO:0043196)
0.6 13.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 12.8 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 570 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 28.7 GO:0004016 adenylate cyclase activity(GO:0004016)
3.8 26.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 23.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 23.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.6 22.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 20.8 GO:0003779 actin binding(GO:0003779)
0.1 19.6 GO:0005096 GTPase activator activity(GO:0005096)
2.7 18.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.8 17.7 GO:0030506 ankyrin binding(GO:0030506)
5.8 17.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
1.4 15.7 GO:0032036 myosin heavy chain binding(GO:0032036)
2.1 14.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
2.9 14.6 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.4 14.1 GO:0030552 cAMP binding(GO:0030552)
1.3 13.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 13.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.4 12.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 12.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 12.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.4 10.8 GO:0001968 fibronectin binding(GO:0001968)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 53.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.5 37.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.4 30.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 27.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 19.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 19.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 18.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.6 18.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.8 13.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 13.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.4 13.6 PID_ENDOTHELIN_PATHWAY Endothelins
0.5 11.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 11.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 9.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.2 8.3 PID_INSULIN_PATHWAY Insulin Pathway
0.1 8.3 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.5 7.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 6.9 PID_FGF_PATHWAY FGF signaling pathway
0.2 6.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 6.0 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 27.0 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
1.0 25.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.1 25.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 22.4 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.6 20.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 19.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.9 18.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 17.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.9 15.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.2 15.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
2.5 14.9 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.9 13.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.6 13.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.4 11.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.4 11.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.4 10.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 9.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 8.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 8.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 8.5 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels